Y-chromosome loss is frequent in male renal tumors
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Y-chromosome loss is frequent in male renal tumors. / Büscheck, Franziska; Fraune, Christoph; Garmestani, Seyedehmina; Simon, Ronald; Kluth, Martina; Hube-Magg, Claudia; Ketterer, Kathrin; Eichelberg, Christian; Höflmayer, Doris; Jacobsen, Frank; Wittmer, Corinna; Wilczak, Waldemar; Sauter, Guido; Fisch, Margit; Eichenauer, Till; Rink, Michael.
in: ANN TRANSL MED, Jahrgang 9, Nr. 3, 02.2021, S. 209.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Y-chromosome loss is frequent in male renal tumors
AU - Büscheck, Franziska
AU - Fraune, Christoph
AU - Garmestani, Seyedehmina
AU - Simon, Ronald
AU - Kluth, Martina
AU - Hube-Magg, Claudia
AU - Ketterer, Kathrin
AU - Eichelberg, Christian
AU - Höflmayer, Doris
AU - Jacobsen, Frank
AU - Wittmer, Corinna
AU - Wilczak, Waldemar
AU - Sauter, Guido
AU - Fisch, Margit
AU - Eichenauer, Till
AU - Rink, Michael
N1 - 2021 Annals of Translational Medicine. All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Background: Loss of the Y-chromosome is a common event in different tumor types but its prevalence and clinical relevance in renal cell tumors is still not understood.Methods: It was the aim of this study to estimate the frequency and clinical relevance of Y-loss in kidney neoplasms. A cohort of 1,252 male renal tumors was analyzed in a tissue microarray format by fluorescence in-situ hybridization (FISH).Results: Y-loss was found in 47% of tumors. The frequency of this alteration varied markedly between kidney tumor subtypes. Y-loss was most prevalent in papillary renal cell carcinoma (RCC) (77%) followed by chromophobe RCC (60%), oncocytoma (51%), clear cell RCC (39%) and clear cell (tubulo)papillary RCC (19%). Y-loss was linked to higher patient age and smaller tumor size at diagnosis. Mean age (95% CI) was 65 (64-66) years in patients with Y-loss in their tumor compared to 60 (58-61) years in patients without Y-loss (P<0.0001). Significant correlations between Y-loss and tumor phenotype were found only for papillary carcinomas (P=0.002), especially for type 1 (P=0.03).Conclusions: Y-loss is present in different histologic subtypes of renal neoplasm. The highest frequency is in papillary RCC, where it may represent a potentially relevant prognostic biomarker suggesting favorable disease outcome.
AB - Background: Loss of the Y-chromosome is a common event in different tumor types but its prevalence and clinical relevance in renal cell tumors is still not understood.Methods: It was the aim of this study to estimate the frequency and clinical relevance of Y-loss in kidney neoplasms. A cohort of 1,252 male renal tumors was analyzed in a tissue microarray format by fluorescence in-situ hybridization (FISH).Results: Y-loss was found in 47% of tumors. The frequency of this alteration varied markedly between kidney tumor subtypes. Y-loss was most prevalent in papillary renal cell carcinoma (RCC) (77%) followed by chromophobe RCC (60%), oncocytoma (51%), clear cell RCC (39%) and clear cell (tubulo)papillary RCC (19%). Y-loss was linked to higher patient age and smaller tumor size at diagnosis. Mean age (95% CI) was 65 (64-66) years in patients with Y-loss in their tumor compared to 60 (58-61) years in patients without Y-loss (P<0.0001). Significant correlations between Y-loss and tumor phenotype were found only for papillary carcinomas (P=0.002), especially for type 1 (P=0.03).Conclusions: Y-loss is present in different histologic subtypes of renal neoplasm. The highest frequency is in papillary RCC, where it may represent a potentially relevant prognostic biomarker suggesting favorable disease outcome.
U2 - 10.21037/atm-20-3061
DO - 10.21037/atm-20-3061
M3 - SCORING: Journal article
C2 - 33708836
VL - 9
SP - 209
JO - ANN TRANSL MED
JF - ANN TRANSL MED
SN - 2305-5839
IS - 3
ER -
