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Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers

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Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers. / Mohammadi, Siawoosh; Carey, Daniel; Dick, Fred; Diedrichsen, Joern; Sereno, Martin I; Reisert, Marco; Callaghan, Martina F; Weiskopf, Nikolaus.

in: FRONT HUM NEUROSCI, Jahrgang 9, 27.11.2015, S. Art. 441.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mohammadi, S, Carey, D, Dick, F, Diedrichsen, J, Sereno, MI, Reisert, M, Callaghan, MF & Weiskopf, N 2015, 'Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers', FRONT HUM NEUROSCI, Jg. 9, S. Art. 441. https://doi.org/10.3389/fnins.2015.00441

APA

Mohammadi, S., Carey, D., Dick, F., Diedrichsen, J., Sereno, M. I., Reisert, M., Callaghan, M. F., & Weiskopf, N. (2015). Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers. FRONT HUM NEUROSCI, 9, Art. 441. https://doi.org/10.3389/fnins.2015.00441

Vancouver

Mohammadi S, Carey D, Dick F, Diedrichsen J, Sereno MI, Reisert M et al. Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers. FRONT HUM NEUROSCI. 2015 Nov 27;9:Art. 441. https://doi.org/10.3389/fnins.2015.00441

Bibtex

@article{92a65ef735c7484c8bbd34724b3ddc66,
title = "Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers",
abstract = "The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an important microstructural characteristic of fiber pathways and is functionally related to conduction velocity. We introduce a novel method for estimating the MR g-ratio non-invasively across the whole brain using high-fidelity magnetization transfer (MT) imaging and single-shell diffusion MRI. These methods enabled us to map the MR g-ratio in vivo across the brain's prominent fiber pathways in a group of 37 healthy volunteers and to estimate the inter-subject variability. Effective correction of susceptibility-related distortion artifacts was essential before combining the MT and diffusion data, in order to reduce partial volume and edge artifacts. The MR g-ratio is in good qualitative agreement with histological findings despite the different resolution and spatial coverage of MRI and histology. The MR g-ratio holds promise as an important non-invasive biomarker due to its microstructural and functional relevance in neurodegeneration.",
author = "Siawoosh Mohammadi and Daniel Carey and Fred Dick and Joern Diedrichsen and Sereno, {Martin I} and Marco Reisert and Callaghan, {Martina F} and Nikolaus Weiskopf",
year = "2015",
month = nov,
day = "27",
doi = "10.3389/fnins.2015.00441",
language = "English",
volume = "9",
pages = "Art. 441",
journal = "FRONT HUM NEUROSCI",
issn = "1662-5161",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Whole-Brain In-vivo Measurements of the Axonal G-Ratio in a Group of 37 Healthy Volunteers

AU - Mohammadi, Siawoosh

AU - Carey, Daniel

AU - Dick, Fred

AU - Diedrichsen, Joern

AU - Sereno, Martin I

AU - Reisert, Marco

AU - Callaghan, Martina F

AU - Weiskopf, Nikolaus

PY - 2015/11/27

Y1 - 2015/11/27

N2 - The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an important microstructural characteristic of fiber pathways and is functionally related to conduction velocity. We introduce a novel method for estimating the MR g-ratio non-invasively across the whole brain using high-fidelity magnetization transfer (MT) imaging and single-shell diffusion MRI. These methods enabled us to map the MR g-ratio in vivo across the brain's prominent fiber pathways in a group of 37 healthy volunteers and to estimate the inter-subject variability. Effective correction of susceptibility-related distortion artifacts was essential before combining the MT and diffusion data, in order to reduce partial volume and edge artifacts. The MR g-ratio is in good qualitative agreement with histological findings despite the different resolution and spatial coverage of MRI and histology. The MR g-ratio holds promise as an important non-invasive biomarker due to its microstructural and functional relevance in neurodegeneration.

AB - The g-ratio, quantifying the ratio between the inner and outer diameters of a fiber, is an important microstructural characteristic of fiber pathways and is functionally related to conduction velocity. We introduce a novel method for estimating the MR g-ratio non-invasively across the whole brain using high-fidelity magnetization transfer (MT) imaging and single-shell diffusion MRI. These methods enabled us to map the MR g-ratio in vivo across the brain's prominent fiber pathways in a group of 37 healthy volunteers and to estimate the inter-subject variability. Effective correction of susceptibility-related distortion artifacts was essential before combining the MT and diffusion data, in order to reduce partial volume and edge artifacts. The MR g-ratio is in good qualitative agreement with histological findings despite the different resolution and spatial coverage of MRI and histology. The MR g-ratio holds promise as an important non-invasive biomarker due to its microstructural and functional relevance in neurodegeneration.

U2 - 10.3389/fnins.2015.00441

DO - 10.3389/fnins.2015.00441

M3 - SCORING: Journal article

C2 - 26640427

VL - 9

SP - Art. 441

JO - FRONT HUM NEUROSCI

JF - FRONT HUM NEUROSCI

SN - 1662-5161

ER -