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White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism

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White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism. / Fründt, Odette; Schulz, Robert; Schöttle, Daniel; Cheng, Bastian; Thomalla, Götz; Braaß, Hanna; Ganos, Christos; David, Nicole; Peiker, Ina; Engel, Andreas K; Bäumer, Tobias; Münchau, Alexander.

in: J AUTISM DEV DISORD, Jahrgang 48, Nr. 2, 02.2018, S. 417-429.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fründt, O, Schulz, R, Schöttle, D, Cheng, B, Thomalla, G, Braaß, H, Ganos, C, David, N, Peiker, I, Engel, AK, Bäumer, T & Münchau, A 2018, 'White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism', J AUTISM DEV DISORD, Jg. 48, Nr. 2, S. 417-429. https://doi.org/10.1007/s10803-017-3332-9

APA

Fründt, O., Schulz, R., Schöttle, D., Cheng, B., Thomalla, G., Braaß, H., Ganos, C., David, N., Peiker, I., Engel, A. K., Bäumer, T., & Münchau, A. (2018). White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism. J AUTISM DEV DISORD, 48(2), 417-429. https://doi.org/10.1007/s10803-017-3332-9

Vancouver

Fründt O, Schulz R, Schöttle D, Cheng B, Thomalla G, Braaß H et al. White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism. J AUTISM DEV DISORD. 2018 Feb;48(2):417-429. https://doi.org/10.1007/s10803-017-3332-9

Bibtex

@article{0ec16d54a847459ca6687b07e40ffa16,
title = "White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism",
abstract = "Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating {"}emulation{"}) and the alternative temporo-frontal route (mediating {"}mimicry{"}). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.",
keywords = "Journal Article",
author = "Odette Fr{\"u}ndt and Robert Schulz and Daniel Sch{\"o}ttle and Bastian Cheng and G{\"o}tz Thomalla and Hanna Braa{\ss} and Christos Ganos and Nicole David and Ina Peiker and Engel, {Andreas K} and Tobias B{\"a}umer and Alexander M{\"u}nchau",
year = "2018",
month = feb,
doi = "10.1007/s10803-017-3332-9",
language = "English",
volume = "48",
pages = "417--429",
journal = "J AUTISM DEV DISORD",
issn = "0162-3257",
publisher = "Plenum Publishers",
number = "2",

}

RIS

TY - JOUR

T1 - White Matter Microstructure of the Human Mirror Neuron System is Related to Symptom Severity in Adults with Autism

AU - Fründt, Odette

AU - Schulz, Robert

AU - Schöttle, Daniel

AU - Cheng, Bastian

AU - Thomalla, Götz

AU - Braaß, Hanna

AU - Ganos, Christos

AU - David, Nicole

AU - Peiker, Ina

AU - Engel, Andreas K

AU - Bäumer, Tobias

AU - Münchau, Alexander

PY - 2018/2

Y1 - 2018/2

N2 - Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.

AB - Mirror neuron system (MNS) dysfunctions might underlie deficits in autism spectrum disorders (ASD). Diffusion tensor imaging based probabilistic tractography was conducted in 15 adult ASD patients and 13 matched, healthy controls. Fractional anisotropy (FA) was quantified to assess group differences in tract-related white matter microstructure of both the classical MNS route (mediating "emulation") and the alternative temporo-frontal route (mediating "mimicry"). Multiple linear regression was used to investigate structure-function relationships between MNS connections and ASD symptom severity. There were no significant group differences in tract-related FA indicating an intact classical MNS in ASD. Direct temporo-frontal connections could not be reconstructed challengeing the concept of multiple routes for imitation. Tract-related FA of right-hemispheric parieto-frontal connections was negatively related to autism symptom severity.

KW - Journal Article

U2 - 10.1007/s10803-017-3332-9

DO - 10.1007/s10803-017-3332-9

M3 - SCORING: Journal article

C2 - 29027066

VL - 48

SP - 417

EP - 429

JO - J AUTISM DEV DISORD

JF - J AUTISM DEV DISORD

SN - 0162-3257

IS - 2

ER -