White matter integrity of premotor-motor connections is associated with motor output in chronic stroke patients
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White matter integrity of premotor-motor connections is associated with motor output in chronic stroke patients. / Schulz, Robert; Braass, Hanna; Liuzzi, Gianpiero; Hoerniss, Vanessa; Lechner, Patricia; Gerloff, Christian; Hummel, Friedhelm C.
in: NEUROIMAGE-CLIN, Jahrgang 7, 11.2014, S. 82-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - White matter integrity of premotor-motor connections is associated with motor output in chronic stroke patients
AU - Schulz, Robert
AU - Braass, Hanna
AU - Liuzzi, Gianpiero
AU - Hoerniss, Vanessa
AU - Lechner, Patricia
AU - Gerloff, Christian
AU - Hummel, Friedhelm C
PY - 2014/11
Y1 - 2014/11
N2 - Corticocortical functional interactions between the primary motor cortex (M1) and secondary motor areas, such as the dorsal (PMd) and ventral (PMv) premotor cortices and the supplementary motor area (SMA) are relevant for residual motor output after subcortical stroke. We hypothesized that the microstructural integrity of the underlying white matter tracts also plays a role in preserved motor output. Using diffusion-tensor imaging we aimed at (i) reconstructing individual probable intrahemispheric connections between M1 and the three secondary areas (PMd, PMv, SMA) and (ii) examining the extent to which the tract-related microstructural integrity correlates with residual motor output. The microstructural integrity of the tract connecting ipsilesional M1 and PMd was significantly associated with motor output (R = 0.78, P = 0.02). The present results support the view that ipsilesional secondary motor areas such as the PMd might support M1 via corticocortical connections to generate motor output after stroke.
AB - Corticocortical functional interactions between the primary motor cortex (M1) and secondary motor areas, such as the dorsal (PMd) and ventral (PMv) premotor cortices and the supplementary motor area (SMA) are relevant for residual motor output after subcortical stroke. We hypothesized that the microstructural integrity of the underlying white matter tracts also plays a role in preserved motor output. Using diffusion-tensor imaging we aimed at (i) reconstructing individual probable intrahemispheric connections between M1 and the three secondary areas (PMd, PMv, SMA) and (ii) examining the extent to which the tract-related microstructural integrity correlates with residual motor output. The microstructural integrity of the tract connecting ipsilesional M1 and PMd was significantly associated with motor output (R = 0.78, P = 0.02). The present results support the view that ipsilesional secondary motor areas such as the PMd might support M1 via corticocortical connections to generate motor output after stroke.
U2 - 10.1016/j.nicl.2014.11.006
DO - 10.1016/j.nicl.2014.11.006
M3 - SCORING: Journal article
C2 - 25610769
VL - 7
SP - 82
EP - 86
JO - NEUROIMAGE-CLIN
JF - NEUROIMAGE-CLIN
SN - 2213-1582
ER -