Voxel-based statistical analysis of fractional anisotropy and mean diffusivity in patients with unilateral temporal lobe epilepsy of unknown cause
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Voxel-based statistical analysis of fractional anisotropy and mean diffusivity in patients with unilateral temporal lobe epilepsy of unknown cause. / Keller, Simon S; Ahrens, Tobias; Mohammadi, Siawoosh; Gerdes, Jan S; Möddel, Gabriel; Kellinghaus, Christoph; Kugel, Harald; Weber, Bernd; Ringelstein, E Bernd; Deppe, Michael.
in: J NEUROIMAGING, Jahrgang 23, Nr. 3, 01.07.2013, S. 352-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Voxel-based statistical analysis of fractional anisotropy and mean diffusivity in patients with unilateral temporal lobe epilepsy of unknown cause
AU - Keller, Simon S
AU - Ahrens, Tobias
AU - Mohammadi, Siawoosh
AU - Gerdes, Jan S
AU - Möddel, Gabriel
AU - Kellinghaus, Christoph
AU - Kugel, Harald
AU - Weber, Bernd
AU - Ringelstein, E Bernd
AU - Deppe, Michael
N1 - Copyright © 2011 by the American Society of Neuroimaging.
PY - 2013/7/1
Y1 - 2013/7/1
N2 - PURPOSE: To determine regional alterations of fractional anisotropy (FA) and mean diffusivity (MD) in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy with unknown cause (TLEu) using diffusion tensor imaging (DTI) and voxel-based statistics (VBS).METHODS: Ten patients with left TLEu and no abnormality on conventional MRI and 81 age-matched neurological healthy controls were studied. VBS analyses were used to compare FA and MD differences between patients and controls. All results were reported using stringent statistical thresholds corrected for multiple comparisons.RESULTS: Patients with TLEu had widespread and bilateral reduction of white matter FA, encompassing the temporal lobes, entire corpus callosum, thalamus, and other regions relative to controls. Increased MD was more spatially limited in patients, but was also observed in the thalamus. FA of the putamen was significantly increased bilaterally in patients relative to controls, which correlated with increasing macroscopic atrophy of the putamen.DISCUSSION: Water diffusion abnormalities are widespread and bilaterally distributed in patients with unilateral TLEu, which are beyond the resolution of conventional MRI. FA alterations are more widespread relative to MD alterations. This is the first study to show evidence of interrelated microscopic (ie, FA increase) and macroscopic (ie, atrophy) alterations of the putamen in patients with TLEu.
AB - PURPOSE: To determine regional alterations of fractional anisotropy (FA) and mean diffusivity (MD) in patients with magnetic resonance imaging (MRI)-negative temporal lobe epilepsy with unknown cause (TLEu) using diffusion tensor imaging (DTI) and voxel-based statistics (VBS).METHODS: Ten patients with left TLEu and no abnormality on conventional MRI and 81 age-matched neurological healthy controls were studied. VBS analyses were used to compare FA and MD differences between patients and controls. All results were reported using stringent statistical thresholds corrected for multiple comparisons.RESULTS: Patients with TLEu had widespread and bilateral reduction of white matter FA, encompassing the temporal lobes, entire corpus callosum, thalamus, and other regions relative to controls. Increased MD was more spatially limited in patients, but was also observed in the thalamus. FA of the putamen was significantly increased bilaterally in patients relative to controls, which correlated with increasing macroscopic atrophy of the putamen.DISCUSSION: Water diffusion abnormalities are widespread and bilaterally distributed in patients with unilateral TLEu, which are beyond the resolution of conventional MRI. FA alterations are more widespread relative to MD alterations. This is the first study to show evidence of interrelated microscopic (ie, FA increase) and macroscopic (ie, atrophy) alterations of the putamen in patients with TLEu.
U2 - 10.1111/j.1552-6569.2011.00673.x
DO - 10.1111/j.1552-6569.2011.00673.x
M3 - SCORING: Journal article
C2 - 22211942
VL - 23
SP - 352
EP - 359
JO - J NEUROIMAGING
JF - J NEUROIMAGING
SN - 1051-2284
IS - 3
ER -