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Volume estimation of the thalamus using freesurfer and stereology

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Volume estimation of the thalamus using freesurfer and stereology : consistency between methods. / Keller, Simon S; Gerdes, Jan S; Mohammadi, Siawoosh; Kellinghaus, Christoph; Kugel, Harald; Deppe, Katja; Ringelstein, E Bernd; Evers, Stefan; Schwindt, Wolfram; Deppe, Michael.

in: NEUROINFORMATICS, Jahrgang 10, Nr. 4, 01.10.2012, S. 341-50.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Keller, SS, Gerdes, JS, Mohammadi, S, Kellinghaus, C, Kugel, H, Deppe, K, Ringelstein, EB, Evers, S, Schwindt, W & Deppe, M 2012, 'Volume estimation of the thalamus using freesurfer and stereology: consistency between methods', NEUROINFORMATICS, Jg. 10, Nr. 4, S. 341-50. https://doi.org/10.1007/s12021-012-9147-0

APA

Keller, S. S., Gerdes, J. S., Mohammadi, S., Kellinghaus, C., Kugel, H., Deppe, K., Ringelstein, E. B., Evers, S., Schwindt, W., & Deppe, M. (2012). Volume estimation of the thalamus using freesurfer and stereology: consistency between methods. NEUROINFORMATICS, 10(4), 341-50. https://doi.org/10.1007/s12021-012-9147-0

Vancouver

Keller SS, Gerdes JS, Mohammadi S, Kellinghaus C, Kugel H, Deppe K et al. Volume estimation of the thalamus using freesurfer and stereology: consistency between methods. NEUROINFORMATICS. 2012 Okt 1;10(4):341-50. https://doi.org/10.1007/s12021-012-9147-0

Bibtex

@article{be2a05954713450798d9e70b214877a5,
title = "Volume estimation of the thalamus using freesurfer and stereology: consistency between methods",
abstract = "Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders. It is important to assess the specificity and validity of automated measurements of structure volumes with respect to reliable manual methods that rely on human anatomical expertise. The thalamus is widely investigated in many neurological and neuropsychiatric disorders using MRI, but thalamic volumes are notoriously difficult to quantify given the poor between-tissue contrast at the thalamic gray-white matter interface. In the present study we investigated the reliability of automatically determined thalamic volume measurements obtained using FreeSurfer software with respect to a manual stereological technique on 3D T1-weighted MR images obtained from a 3 T MR system. Further to demonstrating impressive consistency between stereological and FreeSurfer volume estimates of the thalamus in healthy subjects and neurological patients, we demonstrate that the extent of agreeability between stereology and FreeSurfer is equal to the agreeability between two human anatomists estimating thalamic volume using stereological methods. Using patients with juvenile myoclonic epilepsy as a model for thalamic atrophy, we also show that both automated and manual methods provide very similar ratios of thalamic volume loss in patients. This work promotes the use of FreeSurfer for reliable estimation of global volume in healthy and diseased thalami.",
keywords = "Adult, Analysis of Variance, Atrophy, Brain Mapping, Female, Humans, Imaging, Three-Dimensional, Linear Models, Magnetic Resonance Imaging, Male, Middle Aged, Myoclonic Epilepsy, Juvenile, Nerve Fibers, Myelinated, Software, Stereotaxic Techniques, Thalamus, Young Adult",
author = "Keller, {Simon S} and Gerdes, {Jan S} and Siawoosh Mohammadi and Christoph Kellinghaus and Harald Kugel and Katja Deppe and Ringelstein, {E Bernd} and Stefan Evers and Wolfram Schwindt and Michael Deppe",
year = "2012",
month = oct,
day = "1",
doi = "10.1007/s12021-012-9147-0",
language = "English",
volume = "10",
pages = "341--50",
journal = "NEUROINFORMATICS",
issn = "1539-2791",
publisher = "Humana Press",
number = "4",

}

RIS

TY - JOUR

T1 - Volume estimation of the thalamus using freesurfer and stereology

T2 - consistency between methods

AU - Keller, Simon S

AU - Gerdes, Jan S

AU - Mohammadi, Siawoosh

AU - Kellinghaus, Christoph

AU - Kugel, Harald

AU - Deppe, Katja

AU - Ringelstein, E Bernd

AU - Evers, Stefan

AU - Schwindt, Wolfram

AU - Deppe, Michael

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders. It is important to assess the specificity and validity of automated measurements of structure volumes with respect to reliable manual methods that rely on human anatomical expertise. The thalamus is widely investigated in many neurological and neuropsychiatric disorders using MRI, but thalamic volumes are notoriously difficult to quantify given the poor between-tissue contrast at the thalamic gray-white matter interface. In the present study we investigated the reliability of automatically determined thalamic volume measurements obtained using FreeSurfer software with respect to a manual stereological technique on 3D T1-weighted MR images obtained from a 3 T MR system. Further to demonstrating impressive consistency between stereological and FreeSurfer volume estimates of the thalamus in healthy subjects and neurological patients, we demonstrate that the extent of agreeability between stereology and FreeSurfer is equal to the agreeability between two human anatomists estimating thalamic volume using stereological methods. Using patients with juvenile myoclonic epilepsy as a model for thalamic atrophy, we also show that both automated and manual methods provide very similar ratios of thalamic volume loss in patients. This work promotes the use of FreeSurfer for reliable estimation of global volume in healthy and diseased thalami.

AB - Freely available automated MR image analysis techniques are being increasingly used to investigate neuroanatomical abnormalities in patients with neurological disorders. It is important to assess the specificity and validity of automated measurements of structure volumes with respect to reliable manual methods that rely on human anatomical expertise. The thalamus is widely investigated in many neurological and neuropsychiatric disorders using MRI, but thalamic volumes are notoriously difficult to quantify given the poor between-tissue contrast at the thalamic gray-white matter interface. In the present study we investigated the reliability of automatically determined thalamic volume measurements obtained using FreeSurfer software with respect to a manual stereological technique on 3D T1-weighted MR images obtained from a 3 T MR system. Further to demonstrating impressive consistency between stereological and FreeSurfer volume estimates of the thalamus in healthy subjects and neurological patients, we demonstrate that the extent of agreeability between stereology and FreeSurfer is equal to the agreeability between two human anatomists estimating thalamic volume using stereological methods. Using patients with juvenile myoclonic epilepsy as a model for thalamic atrophy, we also show that both automated and manual methods provide very similar ratios of thalamic volume loss in patients. This work promotes the use of FreeSurfer for reliable estimation of global volume in healthy and diseased thalami.

KW - Adult

KW - Analysis of Variance

KW - Atrophy

KW - Brain Mapping

KW - Female

KW - Humans

KW - Imaging, Three-Dimensional

KW - Linear Models

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Myoclonic Epilepsy, Juvenile

KW - Nerve Fibers, Myelinated

KW - Software

KW - Stereotaxic Techniques

KW - Thalamus

KW - Young Adult

U2 - 10.1007/s12021-012-9147-0

DO - 10.1007/s12021-012-9147-0

M3 - SCORING: Journal article

C2 - 22481382

VL - 10

SP - 341

EP - 350

JO - NEUROINFORMATICS

JF - NEUROINFORMATICS

SN - 1539-2791

IS - 4

ER -