Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience
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Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience. / Bieler, Malte; Sieben, Kay; Schildt, Sandra; Röder, Brigitte; Hanganu-Opatz, Ileana L.
in: SYNAPSE, Jahrgang 71, Nr. 6, 06.2017, S. UNSP e21958.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Visual-tactile processing in primary somatosensory cortex emerges before cross-modal experience
AU - Bieler, Malte
AU - Sieben, Kay
AU - Schildt, Sandra
AU - Röder, Brigitte
AU - Hanganu-Opatz, Ileana L
N1 - © 2017 Wiley Periodicals, Inc.
PY - 2017/6
Y1 - 2017/6
N2 - The presumptive unisensory neocortical areas process multisensory information by oscillatory entrainment of neuronal networks via direct cortico-cortical projections. While neonatal unimodal experience has been identified as necessary for setting up the neuronal networks of multisensory processing, it is still unclear whether early cross-modal experience equally controls the ontogeny of multisensory processing. Here, we assess the development of visual-somatosensory interactions and their anatomical substrate by performing extracellular recordings of network activity in primary sensory cortices in vivo and assessing the cortico-cortical connectivity in pigmented rats. Similar to adult animals, juvenile rats with minimal cross-modal experience display supra-additive augmentation of evoked responses, time-dependent modulation of power and phase reset of network oscillations in response to cross-modal light and whisker stimulation. Moreover, the neuronal discharge of individual neurons is stronger coupled to theta and alpha network oscillations after visual-tactile stimuli. The adult-like multisensory processing of juvenile rats relies on abundant direct visual-somatosensory connections and thalamocortical feedforward interactions. Thus, cellular and network interactions ensuring multisensory processing emerge before cross-modal experience and refine during juvenile development. This article is protected by copyright. All rights reserved.
AB - The presumptive unisensory neocortical areas process multisensory information by oscillatory entrainment of neuronal networks via direct cortico-cortical projections. While neonatal unimodal experience has been identified as necessary for setting up the neuronal networks of multisensory processing, it is still unclear whether early cross-modal experience equally controls the ontogeny of multisensory processing. Here, we assess the development of visual-somatosensory interactions and their anatomical substrate by performing extracellular recordings of network activity in primary sensory cortices in vivo and assessing the cortico-cortical connectivity in pigmented rats. Similar to adult animals, juvenile rats with minimal cross-modal experience display supra-additive augmentation of evoked responses, time-dependent modulation of power and phase reset of network oscillations in response to cross-modal light and whisker stimulation. Moreover, the neuronal discharge of individual neurons is stronger coupled to theta and alpha network oscillations after visual-tactile stimuli. The adult-like multisensory processing of juvenile rats relies on abundant direct visual-somatosensory connections and thalamocortical feedforward interactions. Thus, cellular and network interactions ensuring multisensory processing emerge before cross-modal experience and refine during juvenile development. This article is protected by copyright. All rights reserved.
U2 - 10.1002/syn.21958
DO - 10.1002/syn.21958
M3 - SCORING: Journal article
C2 - 28105686
VL - 71
SP - UNSP e21958
JO - SYNAPSE
JF - SYNAPSE
SN - 0887-4476
IS - 6
ER -