PortalPublikationenVisualizing cellularity and angiogenesis in newly-diagnosed ...

Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging

Standard

Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging. / Liesche-Starnecker, Friederike; Prokop, Georg; Yakushev, Igor; Preibisch, Christine; Delbridge, Claire; Meyer, Hanno S; Aftahy, Kaywan; Barz, Melanie; Meyer, Bernhard; Zimmer, Claus; Schlegel, Jürgen; Wiestler, Benedikt; Gempt, Jens.

in: EJNMMI RES, Jahrgang 11, Nr. 1, 16.08.2021, S. 72.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Liesche-Starnecker, F, Prokop, G, Yakushev, I, Preibisch, C, Delbridge, C, Meyer, HS, Aftahy, K, Barz, M, Meyer, B, Zimmer, C, Schlegel, J, Wiestler, B & Gempt, J 2021, 'Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging', EJNMMI RES, Jg. 11, Nr. 1, S. 72. https://doi.org/10.1186/s13550-021-00817-3

APA

Liesche-Starnecker, F., Prokop, G., Yakushev, I., Preibisch, C., Delbridge, C., Meyer, H. S., Aftahy, K., Barz, M., Meyer, B., Zimmer, C., Schlegel, J., Wiestler, B., & Gempt, J. (2021). Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging. EJNMMI RES, 11(1), 72. https://doi.org/10.1186/s13550-021-00817-3

Vancouver

Liesche-Starnecker F, Prokop G, Yakushev I, Preibisch C, Delbridge C, Meyer HS et al. Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging. EJNMMI RES. 2021 Aug 16;11(1):72. https://doi.org/10.1186/s13550-021-00817-3

Bibtex

@article{9daecdd814c34f87abded6bd6935aeaf,
title = "Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging",
abstract = "PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FET PET) and magnetic resonance imaging (MRI) parameters, including cerebral blood volume (CBV), fractional anisotropy (FA) and mean diffusivity (MD).METHODS: In this prospective cohort, 162 targeted biopsies of 43 patients with therapy-na{\"i}ve, isocitrate dehydrogenase (IDH) wildtype GBM were obtained after defining areas of interest based on imaging parameters [18F] FET PET, CBV, FA and MD. Histopathological analysis of cellularity and neovascularization was conducted and results correlated to imaging data.RESULTS: ANOVA analysis showed a significant increase of CBV in areas with high neovascularization. For diffusion metrics, and in particular FA, a trend for inverse association with neovascularization was found. [18F] FET PET showed a significant positive correlation to cellularity, while CBV also showed a trend towards correlation with cellularity, not reaching significant levels. In contrast, MD and FA were negatively associated with cellularity.CONCLUSION: Our study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively.",
author = "Friederike Liesche-Starnecker and Georg Prokop and Igor Yakushev and Christine Preibisch and Claire Delbridge and Meyer, {Hanno S} and Kaywan Aftahy and Melanie Barz and Bernhard Meyer and Claus Zimmer and J{\"u}rgen Schlegel and Benedikt Wiestler and Jens Gempt",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
day = "16",
doi = "10.1186/s13550-021-00817-3",
language = "English",
volume = "11",
pages = "72",
journal = "EJNMMI RES",
issn = "2191-219X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging

AU - Liesche-Starnecker, Friederike

AU - Prokop, Georg

AU - Yakushev, Igor

AU - Preibisch, Christine

AU - Delbridge, Claire

AU - Meyer, Hanno S

AU - Aftahy, Kaywan

AU - Barz, Melanie

AU - Meyer, Bernhard

AU - Zimmer, Claus

AU - Schlegel, Jürgen

AU - Wiestler, Benedikt

AU - Gempt, Jens

N1 - © 2021. The Author(s).

PY - 2021/8/16

Y1 - 2021/8/16

N2 - PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FET PET) and magnetic resonance imaging (MRI) parameters, including cerebral blood volume (CBV), fractional anisotropy (FA) and mean diffusivity (MD).METHODS: In this prospective cohort, 162 targeted biopsies of 43 patients with therapy-naïve, isocitrate dehydrogenase (IDH) wildtype GBM were obtained after defining areas of interest based on imaging parameters [18F] FET PET, CBV, FA and MD. Histopathological analysis of cellularity and neovascularization was conducted and results correlated to imaging data.RESULTS: ANOVA analysis showed a significant increase of CBV in areas with high neovascularization. For diffusion metrics, and in particular FA, a trend for inverse association with neovascularization was found. [18F] FET PET showed a significant positive correlation to cellularity, while CBV also showed a trend towards correlation with cellularity, not reaching significant levels. In contrast, MD and FA were negatively associated with cellularity.CONCLUSION: Our study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively.

AB - PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FET PET) and magnetic resonance imaging (MRI) parameters, including cerebral blood volume (CBV), fractional anisotropy (FA) and mean diffusivity (MD).METHODS: In this prospective cohort, 162 targeted biopsies of 43 patients with therapy-naïve, isocitrate dehydrogenase (IDH) wildtype GBM were obtained after defining areas of interest based on imaging parameters [18F] FET PET, CBV, FA and MD. Histopathological analysis of cellularity and neovascularization was conducted and results correlated to imaging data.RESULTS: ANOVA analysis showed a significant increase of CBV in areas with high neovascularization. For diffusion metrics, and in particular FA, a trend for inverse association with neovascularization was found. [18F] FET PET showed a significant positive correlation to cellularity, while CBV also showed a trend towards correlation with cellularity, not reaching significant levels. In contrast, MD and FA were negatively associated with cellularity.CONCLUSION: Our study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively.

U2 - 10.1186/s13550-021-00817-3

DO - 10.1186/s13550-021-00817-3

M3 - SCORING: Journal article

C2 - 34398358

VL - 11

SP - 72

JO - EJNMMI RES

JF - EJNMMI RES

SN - 2191-219X

IS - 1

ER -