Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine
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Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine. / Schulte, Laura H; Allers, Angie; May, Arne.
in: NEUROLOGY, Jahrgang 90, Nr. 22, 29.05.2018, S. e1973-e1978.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Visual stimulation leads to activation of the nociceptive trigeminal nucleus in chronic migraine
AU - Schulte, Laura H
AU - Allers, Angie
AU - May, Arne
N1 - © 2018 American Academy of Neurology.
PY - 2018/5/29
Y1 - 2018/5/29
N2 - OBJECTIVE: The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level of the brainstem might lead to enhanced activity within the spinal trigeminal nucleus (sTN) as the main site of trigeminal pain processing within this area.METHODS: Eighteen episodic migraineurs (EM), 17 chronic migraineurs (CM), and 19 healthy controls (HC) underwent one session of high-resolution brainstem imaging during which a rotating checkerboard was presented repeatedly as a visual stimulus. Data were analyzed using SPM12 and MATLAB with the classic first-level-second-level approach of SPM. Analyses of variance were used for group comparisons.RESULTS: CM showed enhanced activation within the sTN as compared to HC. In addition, we observed enhanced activity within the right superior colliculus in CM as compared to HC. When comparing all migraineurs with headaches during scanning with all migraineurs without headaches during scanning and HC, we also found the sTN to be more strongly activated during headaches.CONCLUSION: Our data provide evidence for the existence of visual-nociceptive integration on brainstem level in chronic migraineurs.
AB - OBJECTIVE: The visual system has often been described to be sensitized in migraineurs, with light being perceived as aversive or even painful. One possible explanation for this altered perception is crosslinks between the visual and the trigeminonociceptive system. Visual stimulation in chronic migraineurs on the level of the brainstem might lead to enhanced activity within the spinal trigeminal nucleus (sTN) as the main site of trigeminal pain processing within this area.METHODS: Eighteen episodic migraineurs (EM), 17 chronic migraineurs (CM), and 19 healthy controls (HC) underwent one session of high-resolution brainstem imaging during which a rotating checkerboard was presented repeatedly as a visual stimulus. Data were analyzed using SPM12 and MATLAB with the classic first-level-second-level approach of SPM. Analyses of variance were used for group comparisons.RESULTS: CM showed enhanced activation within the sTN as compared to HC. In addition, we observed enhanced activity within the right superior colliculus in CM as compared to HC. When comparing all migraineurs with headaches during scanning with all migraineurs without headaches during scanning and HC, we also found the sTN to be more strongly activated during headaches.CONCLUSION: Our data provide evidence for the existence of visual-nociceptive integration on brainstem level in chronic migraineurs.
KW - Journal Article
U2 - 10.1212/WNL.0000000000005622
DO - 10.1212/WNL.0000000000005622
M3 - SCORING: Journal article
C2 - 29703770
VL - 90
SP - e1973-e1978
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 22
ER -
