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Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer

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Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer. / Schuster, Matthias; Seebauer, Christian; Rutkowski, Rico; Hauschild, Anna; Podmelle, Fred; Metelmann, Camilla; Metelmann, Bibiana; von Woedtke, Thomas; Hasse, Sybille; Weltmann, Klaus-Dieter; Metelmann, Hans-Robert.

in: J CRANIO MAXILL SURG, Jahrgang 44, Nr. 9, 09.2016, S. 1445-52.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schuster, M, Seebauer, C, Rutkowski, R, Hauschild, A, Podmelle, F, Metelmann, C, Metelmann, B, von Woedtke, T, Hasse, S, Weltmann, K-D & Metelmann, H-R 2016, 'Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer', J CRANIO MAXILL SURG, Jg. 44, Nr. 9, S. 1445-52. https://doi.org/10.1016/j.jcms.2016.07.001

APA

Schuster, M., Seebauer, C., Rutkowski, R., Hauschild, A., Podmelle, F., Metelmann, C., Metelmann, B., von Woedtke, T., Hasse, S., Weltmann, K-D., & Metelmann, H-R. (2016). Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer. J CRANIO MAXILL SURG, 44(9), 1445-52. https://doi.org/10.1016/j.jcms.2016.07.001

Vancouver

Schuster M, Seebauer C, Rutkowski R, Hauschild A, Podmelle F, Metelmann C et al. Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer. J CRANIO MAXILL SURG. 2016 Sep;44(9):1445-52. https://doi.org/10.1016/j.jcms.2016.07.001

Bibtex

@article{784278c970b14162b15bf52ad2f4d53d,
title = "Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer",
abstract = "The aim of the study was to learn, whether clinical application of cold atmospheric pressure plasma (CAP) is able to cause (i) visible tumor surface effects and (ii) apoptotic cell kill in squamous cell carcinoma and (iii) whether CAP-induced visible tumor surface response occurs as often as CAP-induced apoptotic cell kill. Twelve patients with advanced head and neck cancer and infected ulcerations received locally CAP followed by palliative treatment. Four of them revealed tumor surface response appearing 2 weeks after intervention. The tumor surface response expressed as a flat area with vascular stimulation (type 1) or a contraction of tumor ulceration rims forming recesses covered with scabs, in each case surrounded by tumor tissue in visible progress (type 2). In parallel, 9 patients with the same kind of cancer received CAP before radical tumor resection. Tissue specimens were analyzed for apoptotic cells. Apoptotic cells were detectable and occurred more frequently in tissue areas previously treated with CAP than in untreated areas. Bringing together both findings and placing side by side the frequency of clinical tumor surface response and the frequency of analytically proven apoptotic cell kill, detection of apoptotic cells is as common as clinical tumor surface response. There was no patient showing signs of an enhanced or stimulated tumor growth under influence of CAP. CAP was made applicable by a plasma jet, kINPen({\textregistered}) MED (neoplas tools GmbH, Greifswald, Germany). ",
keywords = "Adult, Aged, Apoptosis, Carcinoma, Squamous Cell/pathology, Female, Head and Neck Neoplasms/pathology, Humans, Male, Middle Aged, Neoplasm Staging, Palliative Care, Plasma Gases/therapeutic use",
author = "Matthias Schuster and Christian Seebauer and Rico Rutkowski and Anna Hauschild and Fred Podmelle and Camilla Metelmann and Bibiana Metelmann and {von Woedtke}, Thomas and Sybille Hasse and Klaus-Dieter Weltmann and Hans-Robert Metelmann",
note = "Copyright {\textcopyright} 2016. Published by Elsevier Ltd.",
year = "2016",
month = sep,
doi = "10.1016/j.jcms.2016.07.001",
language = "English",
volume = "44",
pages = "1445--52",
journal = "J CRANIO MAXILL SURG",
issn = "1010-5182",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Visible tumor surface response to physical plasma and apoptotic cell kill in head and neck cancer

AU - Schuster, Matthias

AU - Seebauer, Christian

AU - Rutkowski, Rico

AU - Hauschild, Anna

AU - Podmelle, Fred

AU - Metelmann, Camilla

AU - Metelmann, Bibiana

AU - von Woedtke, Thomas

AU - Hasse, Sybille

AU - Weltmann, Klaus-Dieter

AU - Metelmann, Hans-Robert

N1 - Copyright © 2016. Published by Elsevier Ltd.

PY - 2016/9

Y1 - 2016/9

N2 - The aim of the study was to learn, whether clinical application of cold atmospheric pressure plasma (CAP) is able to cause (i) visible tumor surface effects and (ii) apoptotic cell kill in squamous cell carcinoma and (iii) whether CAP-induced visible tumor surface response occurs as often as CAP-induced apoptotic cell kill. Twelve patients with advanced head and neck cancer and infected ulcerations received locally CAP followed by palliative treatment. Four of them revealed tumor surface response appearing 2 weeks after intervention. The tumor surface response expressed as a flat area with vascular stimulation (type 1) or a contraction of tumor ulceration rims forming recesses covered with scabs, in each case surrounded by tumor tissue in visible progress (type 2). In parallel, 9 patients with the same kind of cancer received CAP before radical tumor resection. Tissue specimens were analyzed for apoptotic cells. Apoptotic cells were detectable and occurred more frequently in tissue areas previously treated with CAP than in untreated areas. Bringing together both findings and placing side by side the frequency of clinical tumor surface response and the frequency of analytically proven apoptotic cell kill, detection of apoptotic cells is as common as clinical tumor surface response. There was no patient showing signs of an enhanced or stimulated tumor growth under influence of CAP. CAP was made applicable by a plasma jet, kINPen(®) MED (neoplas tools GmbH, Greifswald, Germany).

AB - The aim of the study was to learn, whether clinical application of cold atmospheric pressure plasma (CAP) is able to cause (i) visible tumor surface effects and (ii) apoptotic cell kill in squamous cell carcinoma and (iii) whether CAP-induced visible tumor surface response occurs as often as CAP-induced apoptotic cell kill. Twelve patients with advanced head and neck cancer and infected ulcerations received locally CAP followed by palliative treatment. Four of them revealed tumor surface response appearing 2 weeks after intervention. The tumor surface response expressed as a flat area with vascular stimulation (type 1) or a contraction of tumor ulceration rims forming recesses covered with scabs, in each case surrounded by tumor tissue in visible progress (type 2). In parallel, 9 patients with the same kind of cancer received CAP before radical tumor resection. Tissue specimens were analyzed for apoptotic cells. Apoptotic cells were detectable and occurred more frequently in tissue areas previously treated with CAP than in untreated areas. Bringing together both findings and placing side by side the frequency of clinical tumor surface response and the frequency of analytically proven apoptotic cell kill, detection of apoptotic cells is as common as clinical tumor surface response. There was no patient showing signs of an enhanced or stimulated tumor growth under influence of CAP. CAP was made applicable by a plasma jet, kINPen(®) MED (neoplas tools GmbH, Greifswald, Germany).

KW - Adult

KW - Aged

KW - Apoptosis

KW - Carcinoma, Squamous Cell/pathology

KW - Female

KW - Head and Neck Neoplasms/pathology

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Palliative Care

KW - Plasma Gases/therapeutic use

U2 - 10.1016/j.jcms.2016.07.001

DO - 10.1016/j.jcms.2016.07.001

M3 - SCORING: Journal article

C2 - 27499516

VL - 44

SP - 1445

EP - 1452

JO - J CRANIO MAXILL SURG

JF - J CRANIO MAXILL SURG

SN - 1010-5182

IS - 9

ER -