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Violent aggression predicted by multiple pre-adult environmental hits

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Violent aggression predicted by multiple pre-adult environmental hits. / Mitjans, Marina; Seidel, Jan; Begemann, Martin; Bockhop, Fabian; Moya-Higueras, Jorge; Bansal, Vikas; Wesolowski, Janina; Seelbach, Anna; Ibáñez, Manuel Ignacio; Kovacevic, Fatka; Duvar, Oguzhan; Fañanás, Lourdes; Wolf, Hannah-Ulrike; Ortet, Generós; Zwanzger, Peter; Klein, Verena; Lange, Ina; Tänzer, Andreas; Dudeck, Manuela; Penke, Lars; van Elst, Ludger Tebartz; Bittner, Robert A; Schmidmeier, Richard; Freese, Roland; Müller-Isberner, Rüdiger; Wiltfang, Jens; Bliesener, Thomas; Bonn, Stefan; Poustka, Luise; Müller, Jürgen L; Arias, Bárbara; Ehrenreich, Hannelore.

in: MOL PSYCHIATR, Jahrgang 24, Nr. 10, 10.2019, S. 1549-1564.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mitjans, M, Seidel, J, Begemann, M, Bockhop, F, Moya-Higueras, J, Bansal, V, Wesolowski, J, Seelbach, A, Ibáñez, MI, Kovacevic, F, Duvar, O, Fañanás, L, Wolf, H-U, Ortet, G, Zwanzger, P, Klein, V, Lange, I, Tänzer, A, Dudeck, M, Penke, L, van Elst, LT, Bittner, RA, Schmidmeier, R, Freese, R, Müller-Isberner, R, Wiltfang, J, Bliesener, T, Bonn, S, Poustka, L, Müller, JL, Arias, B & Ehrenreich, H 2019, 'Violent aggression predicted by multiple pre-adult environmental hits', MOL PSYCHIATR, Jg. 24, Nr. 10, S. 1549-1564. https://doi.org/10.1038/s41380-018-0043-3

APA

Mitjans, M., Seidel, J., Begemann, M., Bockhop, F., Moya-Higueras, J., Bansal, V., Wesolowski, J., Seelbach, A., Ibáñez, M. I., Kovacevic, F., Duvar, O., Fañanás, L., Wolf, H-U., Ortet, G., Zwanzger, P., Klein, V., Lange, I., Tänzer, A., Dudeck, M., ... Ehrenreich, H. (2019). Violent aggression predicted by multiple pre-adult environmental hits. MOL PSYCHIATR, 24(10), 1549-1564. https://doi.org/10.1038/s41380-018-0043-3

Vancouver

Mitjans M, Seidel J, Begemann M, Bockhop F, Moya-Higueras J, Bansal V et al. Violent aggression predicted by multiple pre-adult environmental hits. MOL PSYCHIATR. 2019 Okt;24(10):1549-1564. https://doi.org/10.1038/s41380-018-0043-3

Bibtex

@article{c5d989675836413cb597aa5725a6875e,
title = "Violent aggression predicted by multiple pre-adult environmental hits",
abstract = "Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.",
keywords = "Journal Article",
author = "Marina Mitjans and Jan Seidel and Martin Begemann and Fabian Bockhop and Jorge Moya-Higueras and Vikas Bansal and Janina Wesolowski and Anna Seelbach and Ib{\'a}{\~n}ez, {Manuel Ignacio} and Fatka Kovacevic and Oguzhan Duvar and Lourdes Fa{\~n}an{\'a}s and Hannah-Ulrike Wolf and Gener{\'o}s Ortet and Peter Zwanzger and Verena Klein and Ina Lange and Andreas T{\"a}nzer and Manuela Dudeck and Lars Penke and {van Elst}, {Ludger Tebartz} and Bittner, {Robert A} and Richard Schmidmeier and Roland Freese and R{\"u}diger M{\"u}ller-Isberner and Jens Wiltfang and Thomas Bliesener and Stefan Bonn and Luise Poustka and M{\"u}ller, {J{\"u}rgen L} and B{\'a}rbara Arias and Hannelore Ehrenreich",
year = "2019",
month = oct,
doi = "10.1038/s41380-018-0043-3",
language = "English",
volume = "24",
pages = "1549--1564",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Violent aggression predicted by multiple pre-adult environmental hits

AU - Mitjans, Marina

AU - Seidel, Jan

AU - Begemann, Martin

AU - Bockhop, Fabian

AU - Moya-Higueras, Jorge

AU - Bansal, Vikas

AU - Wesolowski, Janina

AU - Seelbach, Anna

AU - Ibáñez, Manuel Ignacio

AU - Kovacevic, Fatka

AU - Duvar, Oguzhan

AU - Fañanás, Lourdes

AU - Wolf, Hannah-Ulrike

AU - Ortet, Generós

AU - Zwanzger, Peter

AU - Klein, Verena

AU - Lange, Ina

AU - Tänzer, Andreas

AU - Dudeck, Manuela

AU - Penke, Lars

AU - van Elst, Ludger Tebartz

AU - Bittner, Robert A

AU - Schmidmeier, Richard

AU - Freese, Roland

AU - Müller-Isberner, Rüdiger

AU - Wiltfang, Jens

AU - Bliesener, Thomas

AU - Bonn, Stefan

AU - Poustka, Luise

AU - Müller, Jürgen L

AU - Arias, Bárbara

AU - Ehrenreich, Hannelore

PY - 2019/10

Y1 - 2019/10

N2 - Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.

AB - Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as 'umbrella mediator' of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention.

KW - Journal Article

U2 - 10.1038/s41380-018-0043-3

DO - 10.1038/s41380-018-0043-3

M3 - SCORING: Journal article

C2 - 29795411

VL - 24

SP - 1549

EP - 1564

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 10

ER -