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Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

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Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. / Albaugh, Matthew D; Ivanova, Masha; Chaarani, Bader; Orr, Catherine; Allgaier, Nicholas; Althoff, Robert R; D' Alberto, Nicholas; Hudson, Kelsey; Mackey, Scott; Spechler, Philip A; Banaschewski, Tobias; Brühl, Rüdiger; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Goodman, Robert; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Kappel, Viola; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Penttilä, Jani; Poustka, Luise; Paus, Tomáš; Smolka, Michael N; Struve, Maren; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Garavan, Hugh; Potter, Alexandra S.

in: CEREB CORTEX, Jahrgang 29, Nr. 5, 01.05.2019, S. 1866-1874.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Albaugh, MD, Ivanova, M, Chaarani, B, Orr, C, Allgaier, N, Althoff, RR, D' Alberto, N, Hudson, K, Mackey, S, Spechler, PA, Banaschewski, T, Brühl, R, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Goodman, R, Gowland, P, Grimmer, Y, Heinz, A, Kappel, V, Martinot, J-L, Martinot, M-LP, Nees, F, Papadopoulos Orfanos, D, Penttilä, J, Poustka, L, Paus, T, Smolka, MN, Struve, M, Walter, H, Whelan, R, Schumann, G, Garavan, H & Potter, AS 2019, 'Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood', CEREB CORTEX, Jg. 29, Nr. 5, S. 1866-1874. https://doi.org/10.1093/cercor/bhy066

APA

Albaugh, M. D., Ivanova, M., Chaarani, B., Orr, C., Allgaier, N., Althoff, R. R., D' Alberto, N., Hudson, K., Mackey, S., Spechler, P. A., Banaschewski, T., Brühl, R., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., ... Potter, A. S. (2019). Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. CEREB CORTEX, 29(5), 1866-1874. https://doi.org/10.1093/cercor/bhy066

Vancouver

Albaugh MD, Ivanova M, Chaarani B, Orr C, Allgaier N, Althoff RR et al. Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood. CEREB CORTEX. 2019 Mai 1;29(5):1866-1874. https://doi.org/10.1093/cercor/bhy066

Bibtex

@article{9dcf7fc21d7c44779c288e30e6b0d902,
title = "Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood",
abstract = "Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.",
keywords = "Journal Article",
author = "Albaugh, {Matthew D} and Masha Ivanova and Bader Chaarani and Catherine Orr and Nicholas Allgaier and Althoff, {Robert R} and {D' Alberto}, Nicholas and Kelsey Hudson and Scott Mackey and Spechler, {Philip A} and Tobias Banaschewski and R{\"u}diger Br{\"u}hl and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Robert Goodman and Penny Gowland and Yvonne Grimmer and Andreas Heinz and Viola Kappel and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and {Papadopoulos Orfanos}, Dimitri and Jani Penttil{\"a} and Luise Poustka and Tom{\'a}{\v s} Paus and Smolka, {Michael N} and Maren Struve and Henrik Walter and Robert Whelan and Gunter Schumann and Hugh Garavan and Potter, {Alexandra S}",
note = "{\textcopyright} The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",
year = "2019",
month = may,
day = "1",
doi = "10.1093/cercor/bhy066",
language = "English",
volume = "29",
pages = "1866--1874",
journal = "CEREB CORTEX",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood

AU - Albaugh, Matthew D

AU - Ivanova, Masha

AU - Chaarani, Bader

AU - Orr, Catherine

AU - Allgaier, Nicholas

AU - Althoff, Robert R

AU - D' Alberto, Nicholas

AU - Hudson, Kelsey

AU - Mackey, Scott

AU - Spechler, Philip A

AU - Banaschewski, Tobias

AU - Brühl, Rüdiger

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Goodman, Robert

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Kappel, Viola

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Paus, Tomáš

AU - Smolka, Michael N

AU - Struve, Maren

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Potter, Alexandra S

N1 - © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

AB - Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = -0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.

KW - Journal Article

U2 - 10.1093/cercor/bhy066

DO - 10.1093/cercor/bhy066

M3 - SCORING: Journal article

C2 - 29912404

VL - 29

SP - 1866

EP - 1874

JO - CEREB CORTEX

JF - CEREB CORTEX

SN - 1047-3211

IS - 5

ER -