Velocity encoded cardiovascular magnetic resonance to assess left atrial appendage emptying
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Velocity encoded cardiovascular magnetic resonance to assess left atrial appendage emptying. / Muellerleile, Kai; Sultan, Arian; Groth, Michael; Steven, Daniel; Hoffmann, Boris; Adam, Gerhard; Lund, Gunnar K; Rostock, Thomas; Willems, Stephan.
in: J CARDIOVASC MAGN R, Jahrgang 14, Nr. 1, 39, 21.06.2012.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Velocity encoded cardiovascular magnetic resonance to assess left atrial appendage emptying
AU - Muellerleile, Kai
AU - Sultan, Arian
AU - Groth, Michael
AU - Steven, Daniel
AU - Hoffmann, Boris
AU - Adam, Gerhard
AU - Lund, Gunnar K
AU - Rostock, Thomas
AU - Willems, Stephan
PY - 2012/6/21
Y1 - 2012/6/21
N2 - BACKGROUND: The presence of impaired left atrial appendage (LAA) function identifies patients who are prone to thrombus formation in the LAA and therefore being at high risk for subsequent cardioembolic stroke. LAA function is typically assessed by measurements of LAA emptying velocities using transesophageal echocardiography (TEE) in clinical routine. This study aimed at evaluating the feasibility of assessing LAA emptying by velocity encoded (VENC) cardiovascular magnetic resonance (CMR).METHODS: This study included 30 patients with sinus rhythm (n = 18) or atrial fibrillation (n = 12). VENC-CMR velocity measurements were performed perpendicular to the orifice of the LAA. Peak velocities were measured of passive diastolic LAA emptying (e-wave) in all patients. Peak velocities of active, late-diastolic LAA emptying (a-wave) were assessed in patients with sinus rhythm. Correlation and agreement was analyzed between VENC-CMR and TEE measurements of e- and a-wave peak velocities.RESULTS: A significant correlation and good agreement was found between VENC-CMR and TEE measurements of maximal e-wave velocities (r = 0.61, P < 0.001; mean difference 0 ± 10 cm/s). The a-wave was detectable by VENC-CMR in all patients with sinus rhythm. Correlation was also significant for measurements of peak a-wave velocities between VENC-CMR and TEE (r = 0.71, P < 0.001). There was no significant correlation of LAA emptying velocities with clinical characteristics and only a modest negative correlation of passive LAA emptying with LA function.CONCLUSIONS: The assessment of active and passive LAA emptying by VENC-CMR is feasible. Further evaluation is required of potential future clinical applications such as risk stratification for cardioembolic stroke.
AB - BACKGROUND: The presence of impaired left atrial appendage (LAA) function identifies patients who are prone to thrombus formation in the LAA and therefore being at high risk for subsequent cardioembolic stroke. LAA function is typically assessed by measurements of LAA emptying velocities using transesophageal echocardiography (TEE) in clinical routine. This study aimed at evaluating the feasibility of assessing LAA emptying by velocity encoded (VENC) cardiovascular magnetic resonance (CMR).METHODS: This study included 30 patients with sinus rhythm (n = 18) or atrial fibrillation (n = 12). VENC-CMR velocity measurements were performed perpendicular to the orifice of the LAA. Peak velocities were measured of passive diastolic LAA emptying (e-wave) in all patients. Peak velocities of active, late-diastolic LAA emptying (a-wave) were assessed in patients with sinus rhythm. Correlation and agreement was analyzed between VENC-CMR and TEE measurements of e- and a-wave peak velocities.RESULTS: A significant correlation and good agreement was found between VENC-CMR and TEE measurements of maximal e-wave velocities (r = 0.61, P < 0.001; mean difference 0 ± 10 cm/s). The a-wave was detectable by VENC-CMR in all patients with sinus rhythm. Correlation was also significant for measurements of peak a-wave velocities between VENC-CMR and TEE (r = 0.71, P < 0.001). There was no significant correlation of LAA emptying velocities with clinical characteristics and only a modest negative correlation of passive LAA emptying with LA function.CONCLUSIONS: The assessment of active and passive LAA emptying by VENC-CMR is feasible. Further evaluation is required of potential future clinical applications such as risk stratification for cardioembolic stroke.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Reproducibility of Results
KW - Feasibility Studies
KW - Blood Flow Velocity
KW - Stroke Volume
KW - Echocardiography, Transesophageal
KW - Magnetic Resonance Imaging, Cine/methods
KW - Atrial Appendage/pathology/physiopathology/ultrasonography
KW - Atrial Fibrillation/diagnosis/physiopathology
KW - Atrial Function, Left/physiology
KW - Myocardial Contraction
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Reproducibility of Results
KW - Feasibility Studies
KW - Blood Flow Velocity
KW - Stroke Volume
KW - Echocardiography, Transesophageal
KW - Magnetic Resonance Imaging, Cine/methods
KW - Atrial Appendage/pathology/physiopathology/ultrasonography
KW - Atrial Fibrillation/diagnosis/physiopathology
KW - Atrial Function, Left/physiology
KW - Myocardial Contraction
U2 - 10.1186/1532-429X-14-39
DO - 10.1186/1532-429X-14-39
M3 - SCORING: Journal article
C2 - 22720796
VL - 14
JO - J CARDIOVASC MAGN R
JF - J CARDIOVASC MAGN R
SN - 1097-6647
IS - 1
M1 - 39
ER -
