VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients
Standard
VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients. / Kuerti, Sascha; Oliveira-Ferrer, Leticia; Milde-Langosch, Karin; Schmalfeldt, Barbara; Legler, Karen; Woelber, Linn; Prieske, Katharina; Mahner, Sven; Trillsch, Fabian.
in: ONCOTARGET, Jahrgang 8, Nr. 26, 27.06.2017, S. 43218-43227.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients
AU - Kuerti, Sascha
AU - Oliveira-Ferrer, Leticia
AU - Milde-Langosch, Karin
AU - Schmalfeldt, Barbara
AU - Legler, Karen
AU - Woelber, Linn
AU - Prieske, Katharina
AU - Mahner, Sven
AU - Trillsch, Fabian
PY - 2017/6/27
Y1 - 2017/6/27
N2 - BACKGROUND: Peritoneal dissemination and retroperitoneal lymph node involvement are main routes for progression of epithelial ovarian cancer (EOC). Vascular endothelial growth factor (VEGF) mediated angiogenesis has been identified as an important mechanism promoting tumour progression.METHODS: Tumour tissue of 100 patients with EOC was analysed for protein expression of vascular endothelial growth factor (VEGF)-A, -C, -D by Western Blot analysis. Expression patterns in patients with 'extensive intraperitoneal' metastases (pT3c pN1 and pT3b-pT3c pN0, n=80) were compared to patients with 'predominantly retroperitoneal' metastases (pT1a-pT3b, pN1, n=20). Overall and progression-free survival was analysed by Kaplan-Meier method.RESULTS: While no significant differences in expression levels among the different modes of metastases were noted for VEGF-A and -D, VEGF-C expression was significantly higher in the group of predominantly retroperitoneal metastases compared to the group with extensive intraperitoneal metastases. Patients with high VEGF-C expression had a significantly worse overall survival compared to patients with low expression levels.CONCLUSIONS: Retroperitoneal tumour progression in EOC patients is associated with high VEGF-C expression. VEGF-C may serve as a molecular marker to identify patients with assumed high risk for lymphatic metastases, who might benefit from specific treatment strategies.
AB - BACKGROUND: Peritoneal dissemination and retroperitoneal lymph node involvement are main routes for progression of epithelial ovarian cancer (EOC). Vascular endothelial growth factor (VEGF) mediated angiogenesis has been identified as an important mechanism promoting tumour progression.METHODS: Tumour tissue of 100 patients with EOC was analysed for protein expression of vascular endothelial growth factor (VEGF)-A, -C, -D by Western Blot analysis. Expression patterns in patients with 'extensive intraperitoneal' metastases (pT3c pN1 and pT3b-pT3c pN0, n=80) were compared to patients with 'predominantly retroperitoneal' metastases (pT1a-pT3b, pN1, n=20). Overall and progression-free survival was analysed by Kaplan-Meier method.RESULTS: While no significant differences in expression levels among the different modes of metastases were noted for VEGF-A and -D, VEGF-C expression was significantly higher in the group of predominantly retroperitoneal metastases compared to the group with extensive intraperitoneal metastases. Patients with high VEGF-C expression had a significantly worse overall survival compared to patients with low expression levels.CONCLUSIONS: Retroperitoneal tumour progression in EOC patients is associated with high VEGF-C expression. VEGF-C may serve as a molecular marker to identify patients with assumed high risk for lymphatic metastases, who might benefit from specific treatment strategies.
KW - Journal Article
U2 - 10.18632/oncotarget.17978
DO - 10.18632/oncotarget.17978
M3 - SCORING: Journal article
C2 - 28591727
VL - 8
SP - 43218
EP - 43227
JO - ONCOTARGET
JF - ONCOTARGET
SN - 1949-2553
IS - 26
ER -
