VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.

Xin Lu; Euphemia Mu; Yong Wei; Sabine Riethdorf; Qifeng Yang; Min Yuan; Jun Yan; Yuling Hua; Benjamin J Tiede; Xuemin Lu; Bruce G Haffty; Klaus Pantel; Joan Massagué; Yibin Kang

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.

Standard

VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. / Lu, Xin; Mu, Euphemia; Wei, Yong; Riethdorf, Sabine; Yang, Qifeng; Yuan, Min; Yan, Jun; Hua, Yuling; Tiede, Benjamin J; Lu, Xuemin; Haffty, Bruce G; Pantel, Klaus; Massagué, Joan; Kang, Yibin.

in: CANCER CELL, Jahrgang 20, Nr. 6, 6, 2011, S. 701-714.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lu, X, Mu, E, Wei, Y, Riethdorf, S, Yang, Q, Yuan, M, Yan, J, Hua, Y, Tiede, BJ, Lu, X, Haffty, BG, Pantel, K, Massagué, J & Kang, Y 2011, 'VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.', CANCER CELL, Jg. 20, Nr. 6, 6, S. 701-714. <http://www.ncbi.nlm.nih.gov/pubmed/22137794?dopt=Citation>

APA

Lu, X., Mu, E., Wei, Y., Riethdorf, S., Yang, Q., Yuan, M., Yan, J., Hua, Y., Tiede, B. J., Lu, X., Haffty, B. G., Pantel, K., Massagué, J., & Kang, Y. (2011). VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. CANCER CELL, 20(6), 701-714. [6]. http://www.ncbi.nlm.nih.gov/pubmed/22137794?dopt=Citation

Vancouver

Lu X, Mu E, Wei Y, Riethdorf S, Yang Q, Yuan M et al. VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors. CANCER CELL. 2011;20(6):701-714. 6.

Bibtex

@article{b969c5f934ae4e139fd73e966f7e53d3,

title = "VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.",

abstract = "Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-?B pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacting with the cognate receptor integrin ?4?1, VCAM-1 recruits monocytic osteoclast progenitors and elevates local osteoclast activity. Antibodies against VCAM-1 and integrin ?4 effectively inhibit bone metastasis progression and preserve bone structure. These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone.",

keywords = "Animals, Humans, Female, Mice, Mice, Inbred BALB C, Cell Line, Tumor, Cell Proliferation, Cell Differentiation, Cell Adhesion, Antibodies, Monoclonal/therapeutic use, Bone Neoplasms/metabolism/prevention & control/*secondary, Breast Neoplasms/metabolism/*pathology, Chemotaxis, Integrin alpha4beta1/immunology/*metabolism, Mice, Nude, Molecular Targeted Therapy, NF-kappa B/metabolism, Neoplasm Micrometastasis, Neoplasm Transplantation, Osteoclasts/*metabolism/pathology, Osteolysis/*radiography, Stem Cells/*metabolism/pathology, Transplantation, Heterologous, Vascular Cell Adhesion Molecule-1/genetics/immunology/*metabolism, Animals, Humans, Female, Mice, Mice, Inbred BALB C, Cell Line, Tumor, Cell Proliferation, Cell Differentiation, Cell Adhesion, Antibodies, Monoclonal/therapeutic use, Bone Neoplasms/metabolism/prevention & control/*secondary, Breast Neoplasms/metabolism/*pathology, Chemotaxis, Integrin alpha4beta1/immunology/*metabolism, Mice, Nude, Molecular Targeted Therapy, NF-kappa B/metabolism, Neoplasm Micrometastasis, Neoplasm Transplantation, Osteoclasts/*metabolism/pathology, Osteolysis/*radiography, Stem Cells/*metabolism/pathology, Transplantation, Heterologous, Vascular Cell Adhesion Molecule-1/genetics/immunology/*metabolism",

author = "Xin Lu and Euphemia Mu and Yong Wei and Sabine Riethdorf and Qifeng Yang and Min Yuan and Jun Yan and Yuling Hua and Tiede, {Benjamin J} and Xuemin Lu and Haffty, {Bruce G} and Klaus Pantel and Joan Massagu{\'e} and Yibin Kang",

year = "2011",

language = "English",

volume = "20",

pages = "701--714",

journal = "CANCER CELL",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

}

RIS

TY - JOUR

T1 - VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.

AU - Lu, Xin

AU - Mu, Euphemia

AU - Wei, Yong

AU - Riethdorf, Sabine

AU - Yang, Qifeng

AU - Yuan, Min

AU - Yan, Jun

AU - Hua, Yuling

AU - Tiede, Benjamin J

AU - Lu, Xuemin

AU - Haffty, Bruce G

AU - Pantel, Klaus

AU - Massagué, Joan

AU - Kang, Yibin

PY - 2011

Y1 - 2011

N2 - Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-?B pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacting with the cognate receptor integrin ?4?1, VCAM-1 recruits monocytic osteoclast progenitors and elevates local osteoclast activity. Antibodies against VCAM-1 and integrin ?4 effectively inhibit bone metastasis progression and preserve bone structure. These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone.

AB - Breast cancer patients often develop locoregional or distant recurrence years after mastectomy. Understanding the mechanism of metastatic recurrence after dormancy is crucial for improving the cure rate for breast cancer. Here, we characterize a bone metastasis dormancy model to show that aberrant expression of vascular cell adhesion molecule 1 (VCAM-1), in part dependent on the activity of the NF-?B pathway, promotes the transition from indolent micrometastasis to overt metastasis. By interacting with the cognate receptor integrin ?4?1, VCAM-1 recruits monocytic osteoclast progenitors and elevates local osteoclast activity. Antibodies against VCAM-1 and integrin ?4 effectively inhibit bone metastasis progression and preserve bone structure. These findings establish VCAM-1 as a promising target for the prevention and inhibition of metastatic recurrence in bone.

KW - Animals

KW - Humans

KW - Female

KW - Mice

KW - Mice, Inbred BALB C

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Cell Differentiation

KW - Cell Adhesion

KW - Antibodies, Monoclonal/therapeutic use

KW - Bone Neoplasms/metabolism/prevention & control/secondary

KW - Breast Neoplasms/metabolism/pathology

KW - Chemotaxis

KW - Integrin alpha4beta1/immunology/metabolism

KW - Mice, Nude

KW - Molecular Targeted Therapy

KW - NF-kappa B/metabolism

KW - Neoplasm Micrometastasis

KW - Neoplasm Transplantation

KW - Osteoclasts/metabolism/pathology

KW - Osteolysis/radiography

KW - Stem Cells/metabolism/pathology

KW - Transplantation, Heterologous

KW - Vascular Cell Adhesion Molecule-1/genetics/immunology/metabolism