Vascular wall cells contribute to tumourigenesis in cutaneous neurofibromas of patients with neurofibromatosis type 1. A comparative histological, ultrastructural and immunohistochemical study.
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Vascular wall cells contribute to tumourigenesis in cutaneous neurofibromas of patients with neurofibromatosis type 1. A comparative histological, ultrastructural and immunohistochemical study. / Friedrich, Reinhard; Holstein, Adolf-Friedrich; Middendorff, Ralf; Davidoff, Michail.
in: ANTICANCER RES, Jahrgang 32, Nr. 5, 5, 2012, S. 2139-2158.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Vascular wall cells contribute to tumourigenesis in cutaneous neurofibromas of patients with neurofibromatosis type 1. A comparative histological, ultrastructural and immunohistochemical study.
AU - Friedrich, Reinhard
AU - Holstein, Adolf-Friedrich
AU - Middendorff, Ralf
AU - Davidoff, Michail
PY - 2012
Y1 - 2012
N2 - Neurofibromas are benign nerve sheath tumours. They occur sporadically, singly or few in number, and in neurofibromatosis type 1 (NF1), an autosomal inherited disease. These tumours are composed of different cell types, e.g. nerve cells (axons and axon sheaths), Schwann cells, mast cells, and fibroblasts. The local control of tumour growth in NF1 is poorly understood. Identification of cell markers could provide new information on the processes that are involved in tumour growth.
AB - Neurofibromas are benign nerve sheath tumours. They occur sporadically, singly or few in number, and in neurofibromatosis type 1 (NF1), an autosomal inherited disease. These tumours are composed of different cell types, e.g. nerve cells (axons and axon sheaths), Schwann cells, mast cells, and fibroblasts. The local control of tumour growth in NF1 is poorly understood. Identification of cell markers could provide new information on the processes that are involved in tumour growth.
KW - Humans
KW - Immunohistochemistry
KW - Microscopy, Electron
KW - Neurofibromatosis 1/pathology
KW - Brain-Derived Neurotrophic Factor/analysis
KW - Glial Cell Line-Derived Neurotrophic Factor/analysis
KW - Glial Fibrillary Acidic Protein/analysis
KW - Glucose Transporter Type 1/analysis
KW - Muscle, Smooth, Vascular/pathology
KW - Myocytes, Smooth Muscle/pathology
KW - Nerve Growth Factors/analysis
KW - Neurofibroma/chemistry/pathology/ultrastructure
KW - Receptor, Nerve Growth Factor/analysis
KW - Skin Neoplasms/chemistry/pathology/ultrastructure
KW - Ubiquitin Thiolesterase/analysis
KW - Humans
KW - Immunohistochemistry
KW - Microscopy, Electron
KW - Neurofibromatosis 1/pathology
KW - Brain-Derived Neurotrophic Factor/analysis
KW - Glial Cell Line-Derived Neurotrophic Factor/analysis
KW - Glial Fibrillary Acidic Protein/analysis
KW - Glucose Transporter Type 1/analysis
KW - Muscle, Smooth, Vascular/pathology
KW - Myocytes, Smooth Muscle/pathology
KW - Nerve Growth Factors/analysis
KW - Neurofibroma/chemistry/pathology/ultrastructure
KW - Receptor, Nerve Growth Factor/analysis
KW - Skin Neoplasms/chemistry/pathology/ultrastructure
KW - Ubiquitin Thiolesterase/analysis
M3 - SCORING: Journal article
VL - 32
SP - 2139
EP - 2158
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 5
M1 - 5
ER -
