Variability of quantitative measurements of metastatic liver lesions: a multi-radiation-dose-level and multi-reader comparison
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Variability of quantitative measurements of metastatic liver lesions: a multi-radiation-dose-level and multi-reader comparison. / Ding, Yuqin; Marin, Daniele; Vernuccio, Federica; Gonzalez, Fernando; Williamson, Hannah V; Becker, Hans-Christoph; Patel, Bhavik N; Solomon, Justin; Ramirez-Giraldo, Juan Carlos; Samei, Ehsan; Nelson, Rendon C; Meyer, Mathias.
in: ABDOM RADIOL, Jahrgang 46, Nr. 1, 01.2021, S. 226-236.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Variability of quantitative measurements of metastatic liver lesions: a multi-radiation-dose-level and multi-reader comparison
AU - Ding, Yuqin
AU - Marin, Daniele
AU - Vernuccio, Federica
AU - Gonzalez, Fernando
AU - Williamson, Hannah V
AU - Becker, Hans-Christoph
AU - Patel, Bhavik N
AU - Solomon, Justin
AU - Ramirez-Giraldo, Juan Carlos
AU - Samei, Ehsan
AU - Nelson, Rendon C
AU - Meyer, Mathias
PY - 2021/1
Y1 - 2021/1
N2 - PURPOSE: To evaluate the variability of quantitative measurements of metastatic liver lesions by using a multi-radiation-dose-level and multi-reader comparison.METHODS: Twenty-three study subjects (mean age, 60 years) with 39 liver lesions who underwent a single-energy dual-source contrast-enhanced staging CT between June 2015 and December 2015 were included. CT data were reconstructed with seven different radiation dose levels (ranging from 25 to 100%) on the basis of a single CT acquisition. Four radiologists independently performed manual tumor measurements and two radiologists performed semi-automated tumor measurements. Interobserver, intraobserver, and interdose sources of variability for longest diameter and volumetric measurements were estimated and compared using Wilcoxon rank-sum tests and intraclass correlation coefficients.RESULTS: Inter- and intraobserver variabilities for manual measurements of the longest diameter were higher compared to semi-automated measurements (p < 0.001 for overall). Inter- and intraobserver variabilities of volume measurements were higher compared to the longest diameter measurement (p < 0.001 for overall). Quantitative measurements were statistically different at < 50% radiation dose levels for semi-automated measurements of the longest diameter, and at 25% radiation dose level for volumetric measurements. The variability related to radiation dose was not significantly different from the inter- and intraobserver variability for the measurements of the longest diameter.CONCLUSION: The variability related to radiation dose is comparable to the inter- and intraobserver variability for measurements of the longest diameter. Caution should be warranted in reducing radiation dose level below 50% of a conventional CT protocol due to the potentially detrimental impact on the assessment of lesion response in the liver.
AB - PURPOSE: To evaluate the variability of quantitative measurements of metastatic liver lesions by using a multi-radiation-dose-level and multi-reader comparison.METHODS: Twenty-three study subjects (mean age, 60 years) with 39 liver lesions who underwent a single-energy dual-source contrast-enhanced staging CT between June 2015 and December 2015 were included. CT data were reconstructed with seven different radiation dose levels (ranging from 25 to 100%) on the basis of a single CT acquisition. Four radiologists independently performed manual tumor measurements and two radiologists performed semi-automated tumor measurements. Interobserver, intraobserver, and interdose sources of variability for longest diameter and volumetric measurements were estimated and compared using Wilcoxon rank-sum tests and intraclass correlation coefficients.RESULTS: Inter- and intraobserver variabilities for manual measurements of the longest diameter were higher compared to semi-automated measurements (p < 0.001 for overall). Inter- and intraobserver variabilities of volume measurements were higher compared to the longest diameter measurement (p < 0.001 for overall). Quantitative measurements were statistically different at < 50% radiation dose levels for semi-automated measurements of the longest diameter, and at 25% radiation dose level for volumetric measurements. The variability related to radiation dose was not significantly different from the inter- and intraobserver variability for the measurements of the longest diameter.CONCLUSION: The variability related to radiation dose is comparable to the inter- and intraobserver variability for measurements of the longest diameter. Caution should be warranted in reducing radiation dose level below 50% of a conventional CT protocol due to the potentially detrimental impact on the assessment of lesion response in the liver.
U2 - 10.1007/s00261-020-02601-8
DO - 10.1007/s00261-020-02601-8
M3 - SCORING: Journal article
C2 - 32524151
VL - 46
SP - 226
EP - 236
JO - ABDOM RADIOL
JF - ABDOM RADIOL
SN - 2366-004X
IS - 1
ER -