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Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke

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Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke. / Frindel, Carole; Rouanet, Anaïs; Giacalone, Mathilde; Cho, Tae-Hee; Østergaard, Leif; Fiehler, Jens; Pedraza, Salvador; Baron, Jean-Claude; Wiart, Marlène; Berthezène, Yves; Nighoghossian, Norbert; Rousseau, David.

in: STROKE, Jahrgang 46, Nr. 4, 04.2015, S. 976-81.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Frindel, C, Rouanet, A, Giacalone, M, Cho, T-H, Østergaard, L, Fiehler, J, Pedraza, S, Baron, J-C, Wiart, M, Berthezène, Y, Nighoghossian, N & Rousseau, D 2015, 'Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke', STROKE, Jg. 46, Nr. 4, S. 976-81. https://doi.org/10.1161/STROKEAHA.114.008046

APA

Frindel, C., Rouanet, A., Giacalone, M., Cho, T-H., Østergaard, L., Fiehler, J., Pedraza, S., Baron, J-C., Wiart, M., Berthezène, Y., Nighoghossian, N., & Rousseau, D. (2015). Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke. STROKE, 46(4), 976-81. https://doi.org/10.1161/STROKEAHA.114.008046

Vancouver

Frindel C, Rouanet A, Giacalone M, Cho T-H, Østergaard L, Fiehler J et al. Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke. STROKE. 2015 Apr;46(4):976-81. https://doi.org/10.1161/STROKEAHA.114.008046

Bibtex

@article{aaeafc51f319457baa762e9a6ab4c815,
title = "Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke",
abstract = "BACKGROUND AND PURPOSE: This study examines whether lesion shape documented on magnetic resonance diffusion-weighted imaging during acute stroke improves the prediction of the final infarct volume compared with lesion volume only.METHODS: Diffusion-weighted imaging data and clinical information were retrospectively reviewed in 110 consecutive patients who underwent (n=67) or not (n=43) thrombolytic therapy for acute ischemic stroke. Three-dimensional shape analysis was performed on admission diffusion-weighted imaging data and 5 shape descriptors were developed. Final infarct volume was measured on T2-fluid-attenuated inversion recovery imaging data performed 30 days after stroke.RESULTS: Shape analysis of acute ischemic lesion and more specifically the ratio of the bounding box volume to the lesion volume before thrombolytic treatment improved the prediction of the final infarct for patients undergoing thrombolysis (R(2)=0.86 in model with volume; R(2)=0.98 in model with volume and shape).CONCLUSIONS: Our findings suggest that lesion shape contains important predictive information and reflects important environmental factors that might determine the progression of ischemia from the core.",
keywords = "Aged, Aged, 80 and over, Biomarkers, Brain Ischemia, Cerebral Infarction, Diffusion Magnetic Resonance Imaging, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Stroke, Thrombolytic Therapy",
author = "Carole Frindel and Ana{\"i}s Rouanet and Mathilde Giacalone and Tae-Hee Cho and Leif {\O}stergaard and Jens Fiehler and Salvador Pedraza and Jean-Claude Baron and Marl{\`e}ne Wiart and Yves Berthez{\`e}ne and Norbert Nighoghossian and David Rousseau",
note = "{\textcopyright} 2015 American Heart Association, Inc.",
year = "2015",
month = apr,
doi = "10.1161/STROKEAHA.114.008046",
language = "English",
volume = "46",
pages = "976--81",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Validity of shape as a predictive biomarker of final infarct volume in acute ischemic stroke

AU - Frindel, Carole

AU - Rouanet, Anaïs

AU - Giacalone, Mathilde

AU - Cho, Tae-Hee

AU - Østergaard, Leif

AU - Fiehler, Jens

AU - Pedraza, Salvador

AU - Baron, Jean-Claude

AU - Wiart, Marlène

AU - Berthezène, Yves

AU - Nighoghossian, Norbert

AU - Rousseau, David

N1 - © 2015 American Heart Association, Inc.

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND AND PURPOSE: This study examines whether lesion shape documented on magnetic resonance diffusion-weighted imaging during acute stroke improves the prediction of the final infarct volume compared with lesion volume only.METHODS: Diffusion-weighted imaging data and clinical information were retrospectively reviewed in 110 consecutive patients who underwent (n=67) or not (n=43) thrombolytic therapy for acute ischemic stroke. Three-dimensional shape analysis was performed on admission diffusion-weighted imaging data and 5 shape descriptors were developed. Final infarct volume was measured on T2-fluid-attenuated inversion recovery imaging data performed 30 days after stroke.RESULTS: Shape analysis of acute ischemic lesion and more specifically the ratio of the bounding box volume to the lesion volume before thrombolytic treatment improved the prediction of the final infarct for patients undergoing thrombolysis (R(2)=0.86 in model with volume; R(2)=0.98 in model with volume and shape).CONCLUSIONS: Our findings suggest that lesion shape contains important predictive information and reflects important environmental factors that might determine the progression of ischemia from the core.

AB - BACKGROUND AND PURPOSE: This study examines whether lesion shape documented on magnetic resonance diffusion-weighted imaging during acute stroke improves the prediction of the final infarct volume compared with lesion volume only.METHODS: Diffusion-weighted imaging data and clinical information were retrospectively reviewed in 110 consecutive patients who underwent (n=67) or not (n=43) thrombolytic therapy for acute ischemic stroke. Three-dimensional shape analysis was performed on admission diffusion-weighted imaging data and 5 shape descriptors were developed. Final infarct volume was measured on T2-fluid-attenuated inversion recovery imaging data performed 30 days after stroke.RESULTS: Shape analysis of acute ischemic lesion and more specifically the ratio of the bounding box volume to the lesion volume before thrombolytic treatment improved the prediction of the final infarct for patients undergoing thrombolysis (R(2)=0.86 in model with volume; R(2)=0.98 in model with volume and shape).CONCLUSIONS: Our findings suggest that lesion shape contains important predictive information and reflects important environmental factors that might determine the progression of ischemia from the core.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers

KW - Brain Ischemia

KW - Cerebral Infarction

KW - Diffusion Magnetic Resonance Imaging

KW - Disease Progression

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Stroke

KW - Thrombolytic Therapy

U2 - 10.1161/STROKEAHA.114.008046

DO - 10.1161/STROKEAHA.114.008046

M3 - SCORING: Journal article

C2 - 25744520

VL - 46

SP - 976

EP - 981

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 4

ER -