Validation of quantitative estimation of tissue oxygen extraction fraction and deoxygenated blood volume fraction in phantom and in vivo experiments by using MRI.
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Validation of quantitative estimation of tissue oxygen extraction fraction and deoxygenated blood volume fraction in phantom and in vivo experiments by using MRI. / Sedlacik, Jan; Reichenbach, Jürgen R.
in: MAGN RESON MED, Jahrgang 63, Nr. 4, 4, 2010, S. 910-921.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Validation of quantitative estimation of tissue oxygen extraction fraction and deoxygenated blood volume fraction in phantom and in vivo experiments by using MRI.
AU - Sedlacik, Jan
AU - Reichenbach, Jürgen R
PY - 2010
Y1 - 2010
N2 - The blood oxygenation level dependent signal of cerebral tissue can be theoretically derived using a network model formed by randomly oriented infinitely long cylinders. The validation of this model by phantom and in vivo experiments is still an object of research. A network phantom was constructed of solid polypropylene strings immersed in silicone oil, which essentially eliminated the effect of spin diffusion. The volume fraction and magnetic property of the string network was predetermined by independent methods. Ten healthy volunteers were measured for in vivo demonstration. The gradient echo sampled spin echo signal was evaluated with the cylinder network model. We found a strong interdependency between the two network characterizing parameters deoxygenated blood volume and oxygen extraction fraction. Here, different sets of deoxygenated blood volume/oxygen extraction fraction values were able to describe the measured signal equally well. However, by setting one parameter constant to a predetermined value, reasonable estimates of the other parameter were obtained. The same behavior was found for the in vivo demonstration. The signal theory of the cylinder network was validated by a well-characterized phantom. However, the found interdependency that was found between deoxygenated blood volume and oxygen extraction fraction requires an independent estimation of one variable to determine reliable values of the other parameter.
AB - The blood oxygenation level dependent signal of cerebral tissue can be theoretically derived using a network model formed by randomly oriented infinitely long cylinders. The validation of this model by phantom and in vivo experiments is still an object of research. A network phantom was constructed of solid polypropylene strings immersed in silicone oil, which essentially eliminated the effect of spin diffusion. The volume fraction and magnetic property of the string network was predetermined by independent methods. Ten healthy volunteers were measured for in vivo demonstration. The gradient echo sampled spin echo signal was evaluated with the cylinder network model. We found a strong interdependency between the two network characterizing parameters deoxygenated blood volume and oxygen extraction fraction. Here, different sets of deoxygenated blood volume/oxygen extraction fraction values were able to describe the measured signal equally well. However, by setting one parameter constant to a predetermined value, reasonable estimates of the other parameter were obtained. The same behavior was found for the in vivo demonstration. The signal theory of the cylinder network was validated by a well-characterized phantom. However, the found interdependency that was found between deoxygenated blood volume and oxygen extraction fraction requires an independent estimation of one variable to determine reliable values of the other parameter.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Algorithms
KW - Oxygen blood
KW - Magnetic Resonance Imaging methods
KW - Models, Theoretical
KW - Phantoms, Imaging
KW - Blood Volume Determination methods
KW - Brain metabolism
KW - Cerebrovascular Circulation
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Algorithms
KW - Oxygen blood
KW - Magnetic Resonance Imaging methods
KW - Models, Theoretical
KW - Phantoms, Imaging
KW - Blood Volume Determination methods
KW - Brain metabolism
KW - Cerebrovascular Circulation
M3 - SCORING: Zeitschriftenaufsatz
VL - 63
SP - 910
EP - 921
JO - MAGN RESON MED
JF - MAGN RESON MED
SN - 0740-3194
IS - 4
M1 - 4
ER -
