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Using the Drosophila Nephrocyte to Model Podocyte Function and Disease

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Using the Drosophila Nephrocyte to Model Podocyte Function and Disease. / Helmstädter, Martin; Huber, Tobias B; Hermle, Tobias.

in: FRONT PEDIATR, Jahrgang 5, 2017, S. 262.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Helmstädter, M, Huber, TB & Hermle, T 2017, 'Using the Drosophila Nephrocyte to Model Podocyte Function and Disease', FRONT PEDIATR, Jg. 5, S. 262. https://doi.org/10.3389/fped.2017.00262

APA

Helmstädter, M., Huber, T. B., & Hermle, T. (2017). Using the Drosophila Nephrocyte to Model Podocyte Function and Disease. FRONT PEDIATR, 5, 262. https://doi.org/10.3389/fped.2017.00262

Vancouver

Helmstädter M, Huber TB, Hermle T. Using the Drosophila Nephrocyte to Model Podocyte Function and Disease. FRONT PEDIATR. 2017;5:262. https://doi.org/10.3389/fped.2017.00262

Bibtex

@article{0425e1bdef874044b88e713893855ed4,
title = "Using the Drosophila Nephrocyte to Model Podocyte Function and Disease",
abstract = "Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations. Nehphrocytes have been shown to share functional, morphological, and molecular features with podocytes, which form the glomerular filter in vertebrates. Here, we report the progress and the evolving tool-set of this model system. Combining a functional, accessible slit diaphragm with the power of the genetic tool-kit in Drosophila, the nephrocyte has the potential to greatly advance our understanding of the glomerular filtration barrier in health and disease.",
keywords = "Journal Article, Review",
author = "Martin Helmst{\"a}dter and Huber, {Tobias B} and Tobias Hermle",
year = "2017",
doi = "10.3389/fped.2017.00262",
language = "English",
volume = "5",
pages = "262",
journal = "FRONT PEDIATR",
issn = "2296-2360",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Using the Drosophila Nephrocyte to Model Podocyte Function and Disease

AU - Helmstädter, Martin

AU - Huber, Tobias B

AU - Hermle, Tobias

PY - 2017

Y1 - 2017

N2 - Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations. Nehphrocytes have been shown to share functional, morphological, and molecular features with podocytes, which form the glomerular filter in vertebrates. Here, we report the progress and the evolving tool-set of this model system. Combining a functional, accessible slit diaphragm with the power of the genetic tool-kit in Drosophila, the nephrocyte has the potential to greatly advance our understanding of the glomerular filtration barrier in health and disease.

AB - Glomerular disorders are a major cause of end-stage renal disease and effective therapies are often lacking. Nephrocytes are considered to be part of the Drosophila excretory system and form slit diaphragms across cellular membrane invaginations. Nehphrocytes have been shown to share functional, morphological, and molecular features with podocytes, which form the glomerular filter in vertebrates. Here, we report the progress and the evolving tool-set of this model system. Combining a functional, accessible slit diaphragm with the power of the genetic tool-kit in Drosophila, the nephrocyte has the potential to greatly advance our understanding of the glomerular filtration barrier in health and disease.

KW - Journal Article

KW - Review

U2 - 10.3389/fped.2017.00262

DO - 10.3389/fped.2017.00262

M3 - SCORING: Review article

C2 - 29270398

VL - 5

SP - 262

JO - FRONT PEDIATR

JF - FRONT PEDIATR

SN - 2296-2360

ER -