Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide
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Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide. / Lohr, Christian; Beiersdorfer, Antonia; Fischer, Timo; Hirnet, Daniela; Rotermund, Natalie; Sauer, Jessica; Schulz, Kristina; Gee, Christine E.
in: FRONT CELL NEUROSCI, Jahrgang 15, 690147, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Using Genetically Encoded Calcium Indicators to Study Astrocyte Physiology: A Field Guide
AU - Lohr, Christian
AU - Beiersdorfer, Antonia
AU - Fischer, Timo
AU - Hirnet, Daniela
AU - Rotermund, Natalie
AU - Sauer, Jessica
AU - Schulz, Kristina
AU - Gee, Christine E
N1 - SFB 1328; FOR 2419
PY - 2021
Y1 - 2021
N2 - Ca2+ imaging is the most frequently used technique to study glial cell physiology. While chemical Ca2+ indicators served to visualize and measure changes in glial cell cytosolic Ca2+ concentration for several decades, genetically encoded Ca2+ indicators (GECIs) have become state of the art in recent years. Great improvements have been made since the development of the first GECI and a large number of GECIs with different physical properties exist, rendering it difficult to select the optimal Ca2+ indicator. This review discusses some of the most frequently used GECIs and their suitability for glial cell research.
AB - Ca2+ imaging is the most frequently used technique to study glial cell physiology. While chemical Ca2+ indicators served to visualize and measure changes in glial cell cytosolic Ca2+ concentration for several decades, genetically encoded Ca2+ indicators (GECIs) have become state of the art in recent years. Great improvements have been made since the development of the first GECI and a large number of GECIs with different physical properties exist, rendering it difficult to select the optimal Ca2+ indicator. This review discusses some of the most frequently used GECIs and their suitability for glial cell research.
U2 - 10.3389/fncel.2021.690147
DO - 10.3389/fncel.2021.690147
M3 - SCORING: Review article
C2 - 34177468
VL - 15
JO - FRONT CELL NEUROSCI
JF - FRONT CELL NEUROSCI
SN - 1662-5102
M1 - 690147
ER -