Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock.
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Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. / Kreymann, Karl-Georg; de Heer, Geraldine; Nierhaus, Axel; Kluge, Stefan.
in: CRIT CARE MED, Jahrgang 35, Nr. 12, 12, 2007, S. 2677-2685.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock.
AU - Kreymann, Karl-Georg
AU - de Heer, Geraldine
AU - Nierhaus, Axel
AU - Kluge, Stefan
PY - 2007
Y1 - 2007
N2 - OBJECTIVE: There is ongoing debate about the efficacy of polyvalent immunoglobulins as adjunctive therapy for sepsis or septic shock. Two meta-analyses by the Cochrane collaboration calculated a significant reduction in mortality. However, data of the largest study were missing in one, and a subset of four high-quality studies failed to show an effect in the other. To broaden the database, we performed a meta-analysis of all randomized controlled studies published so far. DATA SOURCE: MEDLINE, EMBASE, Cochrane Library of randomized trials, and personal files. STUDY SELECTION: Meta-analysis of all published randomized controlled studies published on polyvalent immunoglobulins (Ig) for treatment of sepsis or septic shock in adults, children, or neonates. DATA EXTRACTION: Twenty-seven trials with a total of 2,202 patients fulfilled the inclusion criteria. DATA SYNTHESIS: As the immunologic state of neonates is different than that of adults or older children, data were evaluated separately for each group. Fifteen trials on 1,492 adults could be included. The pooled effect on mortality was a relative risk of death (RR) of 0.79 (95% confidence interval [CI] 0.69-0.90, p
AB - OBJECTIVE: There is ongoing debate about the efficacy of polyvalent immunoglobulins as adjunctive therapy for sepsis or septic shock. Two meta-analyses by the Cochrane collaboration calculated a significant reduction in mortality. However, data of the largest study were missing in one, and a subset of four high-quality studies failed to show an effect in the other. To broaden the database, we performed a meta-analysis of all randomized controlled studies published so far. DATA SOURCE: MEDLINE, EMBASE, Cochrane Library of randomized trials, and personal files. STUDY SELECTION: Meta-analysis of all published randomized controlled studies published on polyvalent immunoglobulins (Ig) for treatment of sepsis or septic shock in adults, children, or neonates. DATA EXTRACTION: Twenty-seven trials with a total of 2,202 patients fulfilled the inclusion criteria. DATA SYNTHESIS: As the immunologic state of neonates is different than that of adults or older children, data were evaluated separately for each group. Fifteen trials on 1,492 adults could be included. The pooled effect on mortality was a relative risk of death (RR) of 0.79 (95% confidence interval [CI] 0.69-0.90, p
M3 - SCORING: Zeitschriftenaufsatz
VL - 35
SP - 2677
EP - 2685
JO - CRIT CARE MED
JF - CRIT CARE MED
SN - 0090-3493
IS - 12
M1 - 12
ER -