Use of neutron therapy in the management of locally advanced nonresectable primary or recurrent rectal cancer.
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Use of neutron therapy in the management of locally advanced nonresectable primary or recurrent rectal cancer. / Engenhart-Cabillic, R; Debus, J; Prott, F J; Pötter, R; Höver, K H; Breteau, N; Krüll, Andreas.
in: Recent Results Cancer Res, Jahrgang 150, 1998, S. 113-124.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Use of neutron therapy in the management of locally advanced nonresectable primary or recurrent rectal cancer.
AU - Engenhart-Cabillic, R
AU - Debus, J
AU - Prott, F J
AU - Pötter, R
AU - Höver, K H
AU - Breteau, N
AU - Krüll, Andreas
PY - 1998
Y1 - 1998
N2 - Inoperable locally advanced or inoperable recurrent rectal cancer is a difficult problem. Tenesmus, discharge, bleeding and pelvic pain are frequently present and often are associated with infiltration of the sacral plexus. The value of radiotherapy in managing such patients is being appreciated, although up to 40% of the treated patients have no symptomatic response. Improvement in tumor response and control has been scored through efforts to overcome the radio resistance of the hypoxic tumor cells by neutron irradiation. This article is an account of the activity of neutron radiotherapy in such patients. Over 350 patients were entered in studies comparing neutrons used alone and neutrons used in a mixed-beam treatment schedule. At present no therapeutic gain for long-lasting survival has been achieved; however, local control and pain improvement seems to be better with neutrons than with photons.
AB - Inoperable locally advanced or inoperable recurrent rectal cancer is a difficult problem. Tenesmus, discharge, bleeding and pelvic pain are frequently present and often are associated with infiltration of the sacral plexus. The value of radiotherapy in managing such patients is being appreciated, although up to 40% of the treated patients have no symptomatic response. Improvement in tumor response and control has been scored through efforts to overcome the radio resistance of the hypoxic tumor cells by neutron irradiation. This article is an account of the activity of neutron radiotherapy in such patients. Over 350 patients were entered in studies comparing neutrons used alone and neutrons used in a mixed-beam treatment schedule. At present no therapeutic gain for long-lasting survival has been achieved; however, local control and pain improvement seems to be better with neutrons than with photons.
KW - Humans
KW - Survival Rate
KW - Neoplasm Recurrence, Local/radiotherapy
KW - Neutrons/therapeutic use
KW - Rectal Neoplasms/mortality/radiotherapy
KW - Humans
KW - Survival Rate
KW - Neoplasm Recurrence, Local/radiotherapy
KW - Neutrons/therapeutic use
KW - Rectal Neoplasms/mortality/radiotherapy
M3 - SCORING: Journal article
VL - 150
SP - 113
EP - 124
JO - Recent Results Cancer Res
JF - Recent Results Cancer Res
SN - 0080-0015
ER -
