Use of cryopreserved bone marrow in unrelated allogeneic transplantation.
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Use of cryopreserved bone marrow in unrelated allogeneic transplantation. / Stockschläder, M; Krüger, W; Tom Dieck, A; Horstmann, Martin; Altnöder, M; Löliger, C; Fiedler, W; Hoffknecht, M; Erttmann, Rudolf; Zander, A.
in: BONE MARROW TRANSPL, Jahrgang 17, Nr. 2, 2, 1996, S. 197-199.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Use of cryopreserved bone marrow in unrelated allogeneic transplantation.
AU - Stockschläder, M
AU - Krüger, W
AU - Tom Dieck, A
AU - Horstmann, Martin
AU - Altnöder, M
AU - Löliger, C
AU - Fiedler, W
AU - Hoffknecht, M
AU - Erttmann, Rudolf
AU - Zander, A
PY - 1996
Y1 - 1996
N2 - Cryopreservation of donor bone marrow can facilitate scheduling allogeneic bone marrow transplantation (BMT) by affording independence of a preset time for donation. Previously, we and others have shown the feasibility of using cryopreserved related allogeneic bone marrow. Here, we report the results of the first 10 patients receiving cryopreserved unrelated bone marrow between 1992 and 1995. All evaluable patients (n = 9) engrafted. Time to reach an absolute neutrophil count (ANC) >0.2 x 10(9)/1 and ANC >0.5 x 10(9)/l was 21.4 +/- 9.1 days and 22.6 +/- 9.2 days, respectively. The incidence of acute GVHD > or = grade II and chronic GVHD was 75 and 20%, respectively. Five of nine evaluable patients were alive 100 days post-transplantation. We conclude that cryopreserved unrelated donor bone marrow may be used for allogeneic transplantation.
AB - Cryopreservation of donor bone marrow can facilitate scheduling allogeneic bone marrow transplantation (BMT) by affording independence of a preset time for donation. Previously, we and others have shown the feasibility of using cryopreserved related allogeneic bone marrow. Here, we report the results of the first 10 patients receiving cryopreserved unrelated bone marrow between 1992 and 1995. All evaluable patients (n = 9) engrafted. Time to reach an absolute neutrophil count (ANC) >0.2 x 10(9)/1 and ANC >0.5 x 10(9)/l was 21.4 +/- 9.1 days and 22.6 +/- 9.2 days, respectively. The incidence of acute GVHD > or = grade II and chronic GVHD was 75 and 20%, respectively. Five of nine evaluable patients were alive 100 days post-transplantation. We conclude that cryopreserved unrelated donor bone marrow may be used for allogeneic transplantation.
M3 - SCORING: Zeitschriftenaufsatz
VL - 17
SP - 197
EP - 199
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 2
M1 - 2
ER -