Use of cardiac troponin in the early diagnosis of acute myocardial infarction
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Use of cardiac troponin in the early diagnosis of acute myocardial infarction. / Muzyk, Piotr; Twerenbold, Raphael; Morawiec, Beata; Ayala, Pedro Lopez; Boeddinghaus, Jasper; Nestelberger, Thomas; Mueller, Christian; Kawecki, Damian.
in: KARDIOL POL, Jahrgang 78, Nr. 11, 25.11.2020, S. 1099-1106.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Use of cardiac troponin in the early diagnosis of acute myocardial infarction
AU - Muzyk, Piotr
AU - Twerenbold, Raphael
AU - Morawiec, Beata
AU - Ayala, Pedro Lopez
AU - Boeddinghaus, Jasper
AU - Nestelberger, Thomas
AU - Mueller, Christian
AU - Kawecki, Damian
PY - 2020/11/25
Y1 - 2020/11/25
N2 - The diagnosis ofcoronary artery disease, which is one of the most common causes of death and disability worldwide, still remains a significant problem for clinicians. High‑sensitivity cardiac troponin (hs‑cTn) assays became the cornerstone in the diagnostic workup of acute myocardial infarction. Nowadays, they take an important position in diagnostic algorithms. However, there are still some unexplained issues in this field.This review summarizes and emphasizes the crucial role of hs‑cTn in acute coronary syndromes. The 0/1‑hour hs‑cTn algorithm was mentioned for the first time in the 2015 official European Society of Cardiology guidelines on non-ST‑segment‑elevation acute coronary syndromes. It was derived, validated, and implemented for all clinically‑available assays since then. In this review, troponin‑based strategies for rapid rule‑out or rule‑in of non-ST‑segment elevation myocardial infarction are gathered and compared with the update on the official European Society of Cardiology 0/1‑hour pathway with the most recent values of hs‑cTn. The document also focuses on the problem of possible analytic confounders (false‑‑positive and false‑negative results) and compares the usefulness of cTn to other diagnostic techniques (eg, magnetic resonance imaging). The review is divided into short, easy‑to‑read sections emphasizing 6 key messages on how to use and interpret hs‑cTn base algorithms in clinical practice at the emergency department.
AB - The diagnosis ofcoronary artery disease, which is one of the most common causes of death and disability worldwide, still remains a significant problem for clinicians. High‑sensitivity cardiac troponin (hs‑cTn) assays became the cornerstone in the diagnostic workup of acute myocardial infarction. Nowadays, they take an important position in diagnostic algorithms. However, there are still some unexplained issues in this field.This review summarizes and emphasizes the crucial role of hs‑cTn in acute coronary syndromes. The 0/1‑hour hs‑cTn algorithm was mentioned for the first time in the 2015 official European Society of Cardiology guidelines on non-ST‑segment‑elevation acute coronary syndromes. It was derived, validated, and implemented for all clinically‑available assays since then. In this review, troponin‑based strategies for rapid rule‑out or rule‑in of non-ST‑segment elevation myocardial infarction are gathered and compared with the update on the official European Society of Cardiology 0/1‑hour pathway with the most recent values of hs‑cTn. The document also focuses on the problem of possible analytic confounders (false‑‑positive and false‑negative results) and compares the usefulness of cTn to other diagnostic techniques (eg, magnetic resonance imaging). The review is divided into short, easy‑to‑read sections emphasizing 6 key messages on how to use and interpret hs‑cTn base algorithms in clinical practice at the emergency department.
KW - Acute Coronary Syndrome
KW - Biomarkers
KW - Early Diagnosis
KW - Humans
KW - Myocardial Infarction/diagnosis
KW - Troponin
U2 - 10.33963/KP.15585
DO - 10.33963/KP.15585
M3 - SCORING: Review article
C2 - 32847343
VL - 78
SP - 1099
EP - 1106
JO - KARDIOL POL
JF - KARDIOL POL
SN - 0022-9032
IS - 11
ER -