Urine neopterin concentrations as a marker for successful blastocyst implantation after assisted reproductive technologies.

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Urine neopterin concentrations as a marker for successful blastocyst implantation after assisted reproductive technologies. / Melichar, V; Soelder, E; Schroecksnadel, K; Murr, C; Arck, Petra; Wildt, L; Fuchs, D.

in: REPROD BIOMED ONLINE, Jahrgang 20, Nr. 5, 5, 2010, S. 694-698.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{8144d7cdd45e447ab6c955631bb42124,
title = "Urine neopterin concentrations as a marker for successful blastocyst implantation after assisted reproductive technologies.",
abstract = "Successful blastocyst implantation requires intricately orchestrated adaptation processes involving maternal and fetal mediators. The pivotal role of distinct immune response pathways in early pregnancy is widely acknowledged. Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. IDO activity has been proposed to be of high clinical relevance in the context of pregnancy. To date, insights arising from clinical studies on IDO activity and neopterin concentration during the very early days of pregnancy are still few. Early morning urinary neopterin concentrations in 61 women undergoing assisted reproduction treatment (72 cycles in total) were examined, upon exclusion of infections, daily over a period of 2 weeks after embryo transfer. Twenty of the study participants (28%) became successfully pregnant, and four women experienced abortion. Neopterin concentrations significantly increased after blastocyst transfer when implantation was successful (chi-squared=23.291, P",
author = "V Melichar and E Soelder and K Schroecksnadel and C Murr and Petra Arck and L Wildt and D Fuchs",
year = "2010",
doi = "10.1016/j.rbmo.2010.01.016",
language = "Deutsch",
volume = "20",
pages = "694--698",
journal = "REPROD BIOMED ONLINE",
issn = "1472-6483",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Urine neopterin concentrations as a marker for successful blastocyst implantation after assisted reproductive technologies.

AU - Melichar, V

AU - Soelder, E

AU - Schroecksnadel, K

AU - Murr, C

AU - Arck, Petra

AU - Wildt, L

AU - Fuchs, D

PY - 2010

Y1 - 2010

N2 - Successful blastocyst implantation requires intricately orchestrated adaptation processes involving maternal and fetal mediators. The pivotal role of distinct immune response pathways in early pregnancy is widely acknowledged. Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. IDO activity has been proposed to be of high clinical relevance in the context of pregnancy. To date, insights arising from clinical studies on IDO activity and neopterin concentration during the very early days of pregnancy are still few. Early morning urinary neopterin concentrations in 61 women undergoing assisted reproduction treatment (72 cycles in total) were examined, upon exclusion of infections, daily over a period of 2 weeks after embryo transfer. Twenty of the study participants (28%) became successfully pregnant, and four women experienced abortion. Neopterin concentrations significantly increased after blastocyst transfer when implantation was successful (chi-squared=23.291, P

AB - Successful blastocyst implantation requires intricately orchestrated adaptation processes involving maternal and fetal mediators. The pivotal role of distinct immune response pathways in early pregnancy is widely acknowledged. Pro-inflammatory cytokines, e.g. interferon-gamma (IFN-gamma), are the primary inducers of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) and of neopterin biosynthesis by GTP-cyclohydrolase I. IDO activity has been proposed to be of high clinical relevance in the context of pregnancy. To date, insights arising from clinical studies on IDO activity and neopterin concentration during the very early days of pregnancy are still few. Early morning urinary neopterin concentrations in 61 women undergoing assisted reproduction treatment (72 cycles in total) were examined, upon exclusion of infections, daily over a period of 2 weeks after embryo transfer. Twenty of the study participants (28%) became successfully pregnant, and four women experienced abortion. Neopterin concentrations significantly increased after blastocyst transfer when implantation was successful (chi-squared=23.291, P

U2 - 10.1016/j.rbmo.2010.01.016

DO - 10.1016/j.rbmo.2010.01.016

M3 - SCORING: Zeitschriftenaufsatz

VL - 20

SP - 694

EP - 698

JO - REPROD BIOMED ONLINE

JF - REPROD BIOMED ONLINE

SN - 1472-6483

IS - 5

M1 - 5

ER -