PortalPublikationenUrinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate ...

Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study

Standard

Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. / Tampe, Désirée; Hakroush, Samy; Bösherz, Mark-Sebastian; Franz, Jonas; Hofmann-Winkler, Heike; Pöhlmann, Stefan; Kluge, Stefan; Moerer, Onnen; Stadelmann, Christine; Ströbel, Philipp; Winkler, Martin Sebastian; Tampe, Björn.

in: FRONT MED-LAUSANNE, Jahrgang 8, 644715, 2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tampe, D, Hakroush, S, Bösherz, M-S, Franz, J, Hofmann-Winkler, H, Pöhlmann, S, Kluge, S, Moerer, O, Stadelmann, C, Ströbel, P, Winkler, MS & Tampe, B 2021, 'Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study', FRONT MED-LAUSANNE, Jg. 8, 644715. https://doi.org/10.3389/fmed.2021.644715

APA

Tampe, D., Hakroush, S., Bösherz, M-S., Franz, J., Hofmann-Winkler, H., Pöhlmann, S., Kluge, S., Moerer, O., Stadelmann, C., Ströbel, P., Winkler, M. S., & Tampe, B. (2021). Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. FRONT MED-LAUSANNE, 8, [644715]. https://doi.org/10.3389/fmed.2021.644715

Vancouver

Tampe D, Hakroush S, Bösherz M-S, Franz J, Hofmann-Winkler H, Pöhlmann S et al. Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study. FRONT MED-LAUSANNE. 2021;8. 644715. https://doi.org/10.3389/fmed.2021.644715

Bibtex

@article{4472b8a1604943c092de2190127ace06,
title = "Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study",
abstract = "Background: Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed in COVID-19 patients, suggesting that direct viral injury of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed SARS-CoV-2 infection requiring ICU supportive care in a single-center prospective observational study and investigated whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Objectives: The objective of the study was to evaluate whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Results: Urinary SARS-CoV-2 N measured at ICU admission identified patients at risk for AKI in COVID-19 (HR 5.9, 95% CI 1.4-26, p = 0.0095). In addition, the combination of urinary SARS-CoV-2 N and plasma albumin measurements further improved the association with AKI (HR 11.4, 95% CI 2.7-48, p = 0.0016). Finally, combining urinary SARS-CoV-2 N and plasma albumin measurements associated with the length of ICU supportive care (HR 3.3, 95% CI 1.1-9.9, p = 0.0273) and premature death (HR 7.6, 95% CI 1.3-44, p = 0.0240). In contrast, urinary ACE2 and TMPRSS2 did not correlate with AKI in COVID-19. Conclusions: In conclusion, urinary SARS-CoV-2 N levels associate with risk for AKI and correlate with COVID-19 severity.",
author = "D{\'e}sir{\'e}e Tampe and Samy Hakroush and Mark-Sebastian B{\"o}sherz and Jonas Franz and Heike Hofmann-Winkler and Stefan P{\"o}hlmann and Stefan Kluge and Onnen Moerer and Christine Stadelmann and Philipp Str{\"o}bel and Winkler, {Martin Sebastian} and Bj{\"o}rn Tampe",
note = "Copyright {\textcopyright} 2021 Tampe, Hakroush, B{\"o}sherz, Franz, Hofmann-Winkler, P{\"o}hlmann, Kluge, Moerer, Stadelmann, Str{\"o}bel, Winkler and Tampe.",
year = "2021",
doi = "10.3389/fmed.2021.644715",
language = "English",
volume = "8",
journal = "FRONT MED-LAUSANNE",
issn = "2296-858X",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study

AU - Tampe, Désirée

AU - Hakroush, Samy

AU - Bösherz, Mark-Sebastian

AU - Franz, Jonas

AU - Hofmann-Winkler, Heike

AU - Pöhlmann, Stefan

AU - Kluge, Stefan

AU - Moerer, Onnen

AU - Stadelmann, Christine

AU - Ströbel, Philipp

AU - Winkler, Martin Sebastian

AU - Tampe, Björn

N1 - Copyright © 2021 Tampe, Hakroush, Bösherz, Franz, Hofmann-Winkler, Pöhlmann, Kluge, Moerer, Stadelmann, Ströbel, Winkler and Tampe.

PY - 2021

Y1 - 2021

N2 - Background: Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed in COVID-19 patients, suggesting that direct viral injury of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed SARS-CoV-2 infection requiring ICU supportive care in a single-center prospective observational study and investigated whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Objectives: The objective of the study was to evaluate whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Results: Urinary SARS-CoV-2 N measured at ICU admission identified patients at risk for AKI in COVID-19 (HR 5.9, 95% CI 1.4-26, p = 0.0095). In addition, the combination of urinary SARS-CoV-2 N and plasma albumin measurements further improved the association with AKI (HR 11.4, 95% CI 2.7-48, p = 0.0016). Finally, combining urinary SARS-CoV-2 N and plasma albumin measurements associated with the length of ICU supportive care (HR 3.3, 95% CI 1.1-9.9, p = 0.0273) and premature death (HR 7.6, 95% CI 1.3-44, p = 0.0240). In contrast, urinary ACE2 and TMPRSS2 did not correlate with AKI in COVID-19. Conclusions: In conclusion, urinary SARS-CoV-2 N levels associate with risk for AKI and correlate with COVID-19 severity.

AB - Background: Acute kidney injury (AKI) is very common in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease 2019 (COVID-19) and considered as a risk factor for COVID-19 severity. SARS-CoV-2 renal tropism has been observed in COVID-19 patients, suggesting that direct viral injury of the kidneys may contribute to AKI. We examined 20 adult cases with confirmed SARS-CoV-2 infection requiring ICU supportive care in a single-center prospective observational study and investigated whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Objectives: The objective of the study was to evaluate whether urinary markers for viral infection (SARS-CoV-2 N) and shedded cellular membrane proteins (ACE2, TMPRSS2) allow identification of patients at risk for AKI and outcome of COVID-19. Results: Urinary SARS-CoV-2 N measured at ICU admission identified patients at risk for AKI in COVID-19 (HR 5.9, 95% CI 1.4-26, p = 0.0095). In addition, the combination of urinary SARS-CoV-2 N and plasma albumin measurements further improved the association with AKI (HR 11.4, 95% CI 2.7-48, p = 0.0016). Finally, combining urinary SARS-CoV-2 N and plasma albumin measurements associated with the length of ICU supportive care (HR 3.3, 95% CI 1.1-9.9, p = 0.0273) and premature death (HR 7.6, 95% CI 1.3-44, p = 0.0240). In contrast, urinary ACE2 and TMPRSS2 did not correlate with AKI in COVID-19. Conclusions: In conclusion, urinary SARS-CoV-2 N levels associate with risk for AKI and correlate with COVID-19 severity.

U2 - 10.3389/fmed.2021.644715

DO - 10.3389/fmed.2021.644715

M3 - SCORING: Journal article

C2 - 34113632

VL - 8

JO - FRONT MED-LAUSANNE

JF - FRONT MED-LAUSANNE

SN - 2296-858X

M1 - 644715

ER -