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Uridine adenosine tetraphosphate

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Uridine adenosine tetraphosphate : a novel endothelium- derived vasoconstrictive factor. / Jankowski, Vera; Tölle, Markus; Vanholder, Raymond; Schönfelder, Gilbert; van der Giet, Markus; Henning, Lars; Schlüter, Hartmut; Paul, Martin; Zidek, Walter; Jankowski, Joachim.

in: NAT MED, Jahrgang 11, Nr. 2, 02.2005, S. 223-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jankowski, V, Tölle, M, Vanholder, R, Schönfelder, G, van der Giet, M, Henning, L, Schlüter, H, Paul, M, Zidek, W & Jankowski, J 2005, 'Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor', NAT MED, Jg. 11, Nr. 2, S. 223-7. https://doi.org/10.1038/nm1188

APA

Jankowski, V., Tölle, M., Vanholder, R., Schönfelder, G., van der Giet, M., Henning, L., Schlüter, H., Paul, M., Zidek, W., & Jankowski, J. (2005). Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. NAT MED, 11(2), 223-7. https://doi.org/10.1038/nm1188

Vancouver

Jankowski V, Tölle M, Vanholder R, Schönfelder G, van der Giet M, Henning L et al. Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. NAT MED. 2005 Feb;11(2):223-7. https://doi.org/10.1038/nm1188

Bibtex

@article{949af61adea2418ca16aa40a73a85a8e,
title = "Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor",
abstract = "Beyond serving as a mechanical barrier, the endothelium has important regulatory functions. The discovery of nitric oxide revolutionized our understanding of vasoregulation. In contrast, the identity of endothelium-derived vasoconstrictive factors (EDCFs) remains unclear. The supernatant obtained from mechanically stimulated human endothelial cells obtained from dermal vessels elicited a vasoconstrictive response in an isolated perfused rat kidney. A purinoceptor blocker had a greater effect than an endothelin receptor blocker in decreasing endothelially derived vasoconstriction in the isolated perfused rat kidney. The nucleotide uridine adenosine tetraphosphate (Up(4)A) was isolated from the supernatant of stimulated human endothelium and identified by mass spectrometry. Up(4)A is likely to exert vasoconstriction predominantly through P2X1 receptors, and probably also through P2Y2 and P2Y4 receptors. Plasma concentrations of Up(4)A that cause vasoconstriction are found in healthy subjects. Stimulation with adenosine 5'-triphosphate (ATP), uridine 5'-triphosphate (UTP), acetylcholine, endothelin, A23187 and mechanical stress releases Up(4)A from endothelium, suggesting that Up(4)A contributes to vascular autoregulation. To our knowledge, Up(4)A is the first dinucleotide isolated from living organisms that contains both purine and pyrimidine moieties. We conclude that Up(4)A is a novel potent nonpeptidic EDCF. Its vasoactive effects, plasma concentrations and its release upon endothelial stimulation strongly suggest that Up(4)A has a functional vasoregulatory role.",
keywords = "Adenine Nucleotides, Animals, Cells, Cultured, Endothelial Cells, Endothelium, Vascular, Humans, In Vitro Techniques, Kidney, Mass Spectrometry, Molecular Weight, Rats, Uracil Nucleotides, Vasoconstrictor Agents, Journal Article, Research Support, Non-U.S. Gov't",
author = "Vera Jankowski and Markus T{\"o}lle and Raymond Vanholder and Gilbert Sch{\"o}nfelder and {van der Giet}, Markus and Lars Henning and Hartmut Schl{\"u}ter and Martin Paul and Walter Zidek and Joachim Jankowski",
year = "2005",
month = feb,
doi = "10.1038/nm1188",
language = "English",
volume = "11",
pages = "223--7",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Uridine adenosine tetraphosphate

T2 - a novel endothelium- derived vasoconstrictive factor

AU - Jankowski, Vera

AU - Tölle, Markus

AU - Vanholder, Raymond

AU - Schönfelder, Gilbert

AU - van der Giet, Markus

AU - Henning, Lars

AU - Schlüter, Hartmut

AU - Paul, Martin

AU - Zidek, Walter

AU - Jankowski, Joachim

PY - 2005/2

Y1 - 2005/2

N2 - Beyond serving as a mechanical barrier, the endothelium has important regulatory functions. The discovery of nitric oxide revolutionized our understanding of vasoregulation. In contrast, the identity of endothelium-derived vasoconstrictive factors (EDCFs) remains unclear. The supernatant obtained from mechanically stimulated human endothelial cells obtained from dermal vessels elicited a vasoconstrictive response in an isolated perfused rat kidney. A purinoceptor blocker had a greater effect than an endothelin receptor blocker in decreasing endothelially derived vasoconstriction in the isolated perfused rat kidney. The nucleotide uridine adenosine tetraphosphate (Up(4)A) was isolated from the supernatant of stimulated human endothelium and identified by mass spectrometry. Up(4)A is likely to exert vasoconstriction predominantly through P2X1 receptors, and probably also through P2Y2 and P2Y4 receptors. Plasma concentrations of Up(4)A that cause vasoconstriction are found in healthy subjects. Stimulation with adenosine 5'-triphosphate (ATP), uridine 5'-triphosphate (UTP), acetylcholine, endothelin, A23187 and mechanical stress releases Up(4)A from endothelium, suggesting that Up(4)A contributes to vascular autoregulation. To our knowledge, Up(4)A is the first dinucleotide isolated from living organisms that contains both purine and pyrimidine moieties. We conclude that Up(4)A is a novel potent nonpeptidic EDCF. Its vasoactive effects, plasma concentrations and its release upon endothelial stimulation strongly suggest that Up(4)A has a functional vasoregulatory role.

AB - Beyond serving as a mechanical barrier, the endothelium has important regulatory functions. The discovery of nitric oxide revolutionized our understanding of vasoregulation. In contrast, the identity of endothelium-derived vasoconstrictive factors (EDCFs) remains unclear. The supernatant obtained from mechanically stimulated human endothelial cells obtained from dermal vessels elicited a vasoconstrictive response in an isolated perfused rat kidney. A purinoceptor blocker had a greater effect than an endothelin receptor blocker in decreasing endothelially derived vasoconstriction in the isolated perfused rat kidney. The nucleotide uridine adenosine tetraphosphate (Up(4)A) was isolated from the supernatant of stimulated human endothelium and identified by mass spectrometry. Up(4)A is likely to exert vasoconstriction predominantly through P2X1 receptors, and probably also through P2Y2 and P2Y4 receptors. Plasma concentrations of Up(4)A that cause vasoconstriction are found in healthy subjects. Stimulation with adenosine 5'-triphosphate (ATP), uridine 5'-triphosphate (UTP), acetylcholine, endothelin, A23187 and mechanical stress releases Up(4)A from endothelium, suggesting that Up(4)A contributes to vascular autoregulation. To our knowledge, Up(4)A is the first dinucleotide isolated from living organisms that contains both purine and pyrimidine moieties. We conclude that Up(4)A is a novel potent nonpeptidic EDCF. Its vasoactive effects, plasma concentrations and its release upon endothelial stimulation strongly suggest that Up(4)A has a functional vasoregulatory role.

KW - Adenine Nucleotides

KW - Animals

KW - Cells, Cultured

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Humans

KW - In Vitro Techniques

KW - Kidney

KW - Mass Spectrometry

KW - Molecular Weight

KW - Rats

KW - Uracil Nucleotides

KW - Vasoconstrictor Agents

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/nm1188

DO - 10.1038/nm1188

M3 - SCORING: Journal article

C2 - 15665829

VL - 11

SP - 223

EP - 227

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 2

ER -