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Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone

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Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone. / Sothmann, Peter; Krumkamp, Ralf; Kreuels, Benno; Sarpong, Nimako; Frank, Clemens; Ehlkes, Lutz; Fobil, Julius; Gyau, Kennedy; Jaeger, Anna; Bosu, Benedicta; Marks, Florian; Owusu-Dabo, Ellis; Salzberger, Bernd; May, Jürgen.

in: PLOS ONE, Jahrgang 10, Nr. 9, 29.09.2015, S. e0139433.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sothmann, P, Krumkamp, R, Kreuels, B, Sarpong, N, Frank, C, Ehlkes, L, Fobil, J, Gyau, K, Jaeger, A, Bosu, B, Marks, F, Owusu-Dabo, E, Salzberger, B & May, J 2015, 'Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone', PLOS ONE, Jg. 10, Nr. 9, S. e0139433. https://doi.org/10.1371/journal.pone.0139433

APA

Sothmann, P., Krumkamp, R., Kreuels, B., Sarpong, N., Frank, C., Ehlkes, L., Fobil, J., Gyau, K., Jaeger, A., Bosu, B., Marks, F., Owusu-Dabo, E., Salzberger, B., & May, J. (2015). Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone. PLOS ONE, 10(9), e0139433. https://doi.org/10.1371/journal.pone.0139433

Vancouver

Sothmann P, Krumkamp R, Kreuels B, Sarpong N, Frank C, Ehlkes L et al. Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone. PLOS ONE. 2015 Sep 29;10(9):e0139433. https://doi.org/10.1371/journal.pone.0139433

Bibtex

@article{28beb007647b4ecbbf935ba1ef4bad06,
title = "Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone",
abstract = "BACKGROUND: Systemic bacterial infections are a major cause of paediatric febrile illness in sub-Saharan Africa. Aim of this study was to assess the effects of social and geographical determinants on the risk of bacteraemia in a rural-urban transition zone in Ghana.METHODS: Children below 15 years of age with fever were recruited at an outpatient department in the suburban belt of Kumasi, Ghana's second largest city. Blood was taken for bacterial culture and malaria diagnostics. The socio-economic status of participants was calculated using Principle Component Analysis. A scale, based on key urban characteristics, was established to quantify urbanicity for all communities in the hospital catchment area. A case-control analysis was conducted, where children with and without bacteraemia were cases and controls, respectively.RESULTS: Bacteraemia was detected in 72 (3.1%) of 2,306 hospital visits. Non-typhoidal Salmonella (NTS; n = 24; 33.3%) and Salmonella typhi (n = 18; 25.0%) were the most common isolates. Logistic regression analysis showed that bacteraemia was negatively associated with urbanicity (odds ratio [OR] = 0.8; 95% confidence interval [CI]: 0.7-1.0) and socio-economic status (OR = 0.8; 95% CI: 0.6-0.9). Both associations were stronger if only NTS infections were used as cases (OR = 0.5; 95% CI: 0.3-0.8 and OR = 0.6; 95% CI: 0.4-1.0, respectively).CONCLUSIONS: The results of this study highlight the importance of individual as well as community factors as independent risk factors for invasive bacterial infection (IBI) and especially NTS. Epidemiological data support physicians, public health experts and policy makers to identify disease prevention and treatment needs in order to secure public health in the transitional societies of developing countries.",
keywords = "Bacteremia, Bacteria, Case-Control Studies, Child, Child, Preschool, Cities, Female, Ghana, Humans, Infant, Logistic Models, Male, Principal Component Analysis, Rural Health, Rural Population, Salmonella, Salmonella Infections, Salmonella typhi, Social Class, Urban Health, Urban Population, Urbanization, Journal Article, Research Support, Non-U.S. Gov't",
author = "Peter Sothmann and Ralf Krumkamp and Benno Kreuels and Nimako Sarpong and Clemens Frank and Lutz Ehlkes and Julius Fobil and Kennedy Gyau and Anna Jaeger and Benedicta Bosu and Florian Marks and Ellis Owusu-Dabo and Bernd Salzberger and J{\"u}rgen May",
year = "2015",
month = sep,
day = "29",
doi = "10.1371/journal.pone.0139433",
language = "English",
volume = "10",
pages = "e0139433",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Urbanicity and Paediatric Bacteraemia in Ghana-A Case-Control Study within a Rural-Urban Transition Zone

AU - Sothmann, Peter

AU - Krumkamp, Ralf

AU - Kreuels, Benno

AU - Sarpong, Nimako

AU - Frank, Clemens

AU - Ehlkes, Lutz

AU - Fobil, Julius

AU - Gyau, Kennedy

AU - Jaeger, Anna

AU - Bosu, Benedicta

AU - Marks, Florian

AU - Owusu-Dabo, Ellis

AU - Salzberger, Bernd

AU - May, Jürgen

PY - 2015/9/29

Y1 - 2015/9/29

N2 - BACKGROUND: Systemic bacterial infections are a major cause of paediatric febrile illness in sub-Saharan Africa. Aim of this study was to assess the effects of social and geographical determinants on the risk of bacteraemia in a rural-urban transition zone in Ghana.METHODS: Children below 15 years of age with fever were recruited at an outpatient department in the suburban belt of Kumasi, Ghana's second largest city. Blood was taken for bacterial culture and malaria diagnostics. The socio-economic status of participants was calculated using Principle Component Analysis. A scale, based on key urban characteristics, was established to quantify urbanicity for all communities in the hospital catchment area. A case-control analysis was conducted, where children with and without bacteraemia were cases and controls, respectively.RESULTS: Bacteraemia was detected in 72 (3.1%) of 2,306 hospital visits. Non-typhoidal Salmonella (NTS; n = 24; 33.3%) and Salmonella typhi (n = 18; 25.0%) were the most common isolates. Logistic regression analysis showed that bacteraemia was negatively associated with urbanicity (odds ratio [OR] = 0.8; 95% confidence interval [CI]: 0.7-1.0) and socio-economic status (OR = 0.8; 95% CI: 0.6-0.9). Both associations were stronger if only NTS infections were used as cases (OR = 0.5; 95% CI: 0.3-0.8 and OR = 0.6; 95% CI: 0.4-1.0, respectively).CONCLUSIONS: The results of this study highlight the importance of individual as well as community factors as independent risk factors for invasive bacterial infection (IBI) and especially NTS. Epidemiological data support physicians, public health experts and policy makers to identify disease prevention and treatment needs in order to secure public health in the transitional societies of developing countries.

AB - BACKGROUND: Systemic bacterial infections are a major cause of paediatric febrile illness in sub-Saharan Africa. Aim of this study was to assess the effects of social and geographical determinants on the risk of bacteraemia in a rural-urban transition zone in Ghana.METHODS: Children below 15 years of age with fever were recruited at an outpatient department in the suburban belt of Kumasi, Ghana's second largest city. Blood was taken for bacterial culture and malaria diagnostics. The socio-economic status of participants was calculated using Principle Component Analysis. A scale, based on key urban characteristics, was established to quantify urbanicity for all communities in the hospital catchment area. A case-control analysis was conducted, where children with and without bacteraemia were cases and controls, respectively.RESULTS: Bacteraemia was detected in 72 (3.1%) of 2,306 hospital visits. Non-typhoidal Salmonella (NTS; n = 24; 33.3%) and Salmonella typhi (n = 18; 25.0%) were the most common isolates. Logistic regression analysis showed that bacteraemia was negatively associated with urbanicity (odds ratio [OR] = 0.8; 95% confidence interval [CI]: 0.7-1.0) and socio-economic status (OR = 0.8; 95% CI: 0.6-0.9). Both associations were stronger if only NTS infections were used as cases (OR = 0.5; 95% CI: 0.3-0.8 and OR = 0.6; 95% CI: 0.4-1.0, respectively).CONCLUSIONS: The results of this study highlight the importance of individual as well as community factors as independent risk factors for invasive bacterial infection (IBI) and especially NTS. Epidemiological data support physicians, public health experts and policy makers to identify disease prevention and treatment needs in order to secure public health in the transitional societies of developing countries.

KW - Bacteremia

KW - Bacteria

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Cities

KW - Female

KW - Ghana

KW - Humans

KW - Infant

KW - Logistic Models

KW - Male

KW - Principal Component Analysis

KW - Rural Health

KW - Rural Population

KW - Salmonella

KW - Salmonella Infections

KW - Salmonella typhi

KW - Social Class

KW - Urban Health

KW - Urban Population

KW - Urbanization

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0139433

DO - 10.1371/journal.pone.0139433

M3 - SCORING: Journal article

C2 - 26418004

VL - 10

SP - e0139433

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 9

ER -