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Upregulation of centromere protein F is linked to aggressive prostate cancers

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Upregulation of centromere protein F is linked to aggressive prostate cancers. / Göbel, Cosima; Özden, Cansu; Schroeder, Cornelia; Hube-Magg, Claudia; Kluth, Martina; Möller-Koop, Christina; Neubauer, Emily; Hinsch, Andrea; Jacobsen, Frank; Simon, Ronald; Sauter, Guido; Michl, Uwe; Pehrke, Dirk; Huland, Hartwig; Graefen, Markus; Schlomm, Thorsten; Luebke, Andreas M.

in: CANCER MANAG RES, Jahrgang 10, 2018, S. 5491-5504.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Göbel, C, Özden, C, Schroeder, C, Hube-Magg, C, Kluth, M, Möller-Koop, C, Neubauer, E, Hinsch, A, Jacobsen, F, Simon, R, Sauter, G, Michl, U, Pehrke, D, Huland, H, Graefen, M, Schlomm, T & Luebke, AM 2018, 'Upregulation of centromere protein F is linked to aggressive prostate cancers', CANCER MANAG RES, Jg. 10, S. 5491-5504. https://doi.org/10.2147/CMAR.S165630

APA

Göbel, C., Özden, C., Schroeder, C., Hube-Magg, C., Kluth, M., Möller-Koop, C., Neubauer, E., Hinsch, A., Jacobsen, F., Simon, R., Sauter, G., Michl, U., Pehrke, D., Huland, H., Graefen, M., Schlomm, T., & Luebke, A. M. (2018). Upregulation of centromere protein F is linked to aggressive prostate cancers. CANCER MANAG RES, 10, 5491-5504. https://doi.org/10.2147/CMAR.S165630

Vancouver

Göbel C, Özden C, Schroeder C, Hube-Magg C, Kluth M, Möller-Koop C et al. Upregulation of centromere protein F is linked to aggressive prostate cancers. CANCER MANAG RES. 2018;10:5491-5504. https://doi.org/10.2147/CMAR.S165630

Bibtex

@article{60647a64675f4f3dbdb5f566679fc02a,
title = "Upregulation of centromere protein F is linked to aggressive prostate cancers",
abstract = "Background: Centromere protein F (CENPF) is a key component of the kinetochore complex and plays a crucial role in chromosome segregation and cell cycle progression. Recent work suggests that CENPF upregulation is linked to aggressive tumor features in a variety of malignancies including prostate cancer.Materials and methods: Using a highly annotated tissue microarray, we analyzed CENPF protein expression from a cohort of 8,298 prostatectomized patients by immunohistochemistry to study its effect on prostate-specific antigen recurrence-free survival.Results: CENPF overexpression was found in 53% of cancers, and was linked to higher Gleason grade, advanced pathological tumor stage, accelerated cell proliferation, and lymph node metastasis (p<0.0001, each). A comparison with other key molecular features accessible through the microarray revealed strong associations between CENPF overexpression and presence of erythroblast transformation-specific (ETS)-related gene (ERG) fusion as well as phosphatase and tensin homolog deletion (p<0.0001, each). CENPF overexpression was linked to early biochemical recurrence. A subset analysis revealed that this was driven by the ERG-negative subset (p<0.0001). This was independent of established preoperative and postoperative prognostic parameters in multivariate analyses.Conclusion: The results of our study identify CENPF overexpression as an important mechanism and a potential biomarker for prostate cancer aggressiveness.",
keywords = "Journal Article",
author = "Cosima G{\"o}bel and Cansu {\"O}zden and Cornelia Schroeder and Claudia Hube-Magg and Martina Kluth and Christina M{\"o}ller-Koop and Emily Neubauer and Andrea Hinsch and Frank Jacobsen and Ronald Simon and Guido Sauter and Uwe Michl and Dirk Pehrke and Hartwig Huland and Markus Graefen and Thorsten Schlomm and Luebke, {Andreas M}",
year = "2018",
doi = "10.2147/CMAR.S165630",
language = "English",
volume = "10",
pages = "5491--5504",
journal = "CANCER MANAG RES",
issn = "1179-1322",
publisher = "DOVE MEDICAL PRESS LTD",

}

RIS

TY - JOUR

T1 - Upregulation of centromere protein F is linked to aggressive prostate cancers

AU - Göbel, Cosima

AU - Özden, Cansu

AU - Schroeder, Cornelia

AU - Hube-Magg, Claudia

AU - Kluth, Martina

AU - Möller-Koop, Christina

AU - Neubauer, Emily

AU - Hinsch, Andrea

AU - Jacobsen, Frank

AU - Simon, Ronald

AU - Sauter, Guido

AU - Michl, Uwe

AU - Pehrke, Dirk

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Schlomm, Thorsten

AU - Luebke, Andreas M

PY - 2018

Y1 - 2018

N2 - Background: Centromere protein F (CENPF) is a key component of the kinetochore complex and plays a crucial role in chromosome segregation and cell cycle progression. Recent work suggests that CENPF upregulation is linked to aggressive tumor features in a variety of malignancies including prostate cancer.Materials and methods: Using a highly annotated tissue microarray, we analyzed CENPF protein expression from a cohort of 8,298 prostatectomized patients by immunohistochemistry to study its effect on prostate-specific antigen recurrence-free survival.Results: CENPF overexpression was found in 53% of cancers, and was linked to higher Gleason grade, advanced pathological tumor stage, accelerated cell proliferation, and lymph node metastasis (p<0.0001, each). A comparison with other key molecular features accessible through the microarray revealed strong associations between CENPF overexpression and presence of erythroblast transformation-specific (ETS)-related gene (ERG) fusion as well as phosphatase and tensin homolog deletion (p<0.0001, each). CENPF overexpression was linked to early biochemical recurrence. A subset analysis revealed that this was driven by the ERG-negative subset (p<0.0001). This was independent of established preoperative and postoperative prognostic parameters in multivariate analyses.Conclusion: The results of our study identify CENPF overexpression as an important mechanism and a potential biomarker for prostate cancer aggressiveness.

AB - Background: Centromere protein F (CENPF) is a key component of the kinetochore complex and plays a crucial role in chromosome segregation and cell cycle progression. Recent work suggests that CENPF upregulation is linked to aggressive tumor features in a variety of malignancies including prostate cancer.Materials and methods: Using a highly annotated tissue microarray, we analyzed CENPF protein expression from a cohort of 8,298 prostatectomized patients by immunohistochemistry to study its effect on prostate-specific antigen recurrence-free survival.Results: CENPF overexpression was found in 53% of cancers, and was linked to higher Gleason grade, advanced pathological tumor stage, accelerated cell proliferation, and lymph node metastasis (p<0.0001, each). A comparison with other key molecular features accessible through the microarray revealed strong associations between CENPF overexpression and presence of erythroblast transformation-specific (ETS)-related gene (ERG) fusion as well as phosphatase and tensin homolog deletion (p<0.0001, each). CENPF overexpression was linked to early biochemical recurrence. A subset analysis revealed that this was driven by the ERG-negative subset (p<0.0001). This was independent of established preoperative and postoperative prognostic parameters in multivariate analyses.Conclusion: The results of our study identify CENPF overexpression as an important mechanism and a potential biomarker for prostate cancer aggressiveness.

KW - Journal Article

U2 - 10.2147/CMAR.S165630

DO - 10.2147/CMAR.S165630

M3 - SCORING: Journal article

C2 - 30519097

VL - 10

SP - 5491

EP - 5504

JO - CANCER MANAG RES

JF - CANCER MANAG RES

SN - 1179-1322

ER -