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Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis

Standard

Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. / Grimmig, Tanja; Moll, Eva-Maria; Kloos, Kerstin; Thumm, Rebecca; Moench, Romana; Callies, Simone; Kreckel, Jennifer; Vetterlein, Malte; Pelz, Joerg; Polat, Buelent; Tripathi, Sudipta; Rehder, Roberta; Ribas, Carmen M; Chandraker, Anil; Germer, Christoph-T; Waaga-Gasser, Ana Maria; Gasser, Martin.

in: Cancer Growth and Metastasis, Nr. 10, 18.09.2017, S. 1179064417730559.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grimmig, T, Moll, E-M, Kloos, K, Thumm, R, Moench, R, Callies, S, Kreckel, J, Vetterlein, M, Pelz, J, Polat, B, Tripathi, S, Rehder, R, Ribas, CM, Chandraker, A, Germer, C-T, Waaga-Gasser, AM & Gasser, M 2017, 'Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis', Cancer Growth and Metastasis, Nr. 10, S. 1179064417730559. https://doi.org/10.1177/1179064417730559

APA

Grimmig, T., Moll, E-M., Kloos, K., Thumm, R., Moench, R., Callies, S., Kreckel, J., Vetterlein, M., Pelz, J., Polat, B., Tripathi, S., Rehder, R., Ribas, C. M., Chandraker, A., Germer, C-T., Waaga-Gasser, A. M., & Gasser, M. (2017). Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. Cancer Growth and Metastasis, (10), 1179064417730559. https://doi.org/10.1177/1179064417730559

Vancouver

Grimmig T, Moll E-M, Kloos K, Thumm R, Moench R, Callies S et al. Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis. Cancer Growth and Metastasis. 2017 Sep 18;(10):1179064417730559. https://doi.org/10.1177/1179064417730559

Bibtex

@article{0ab5e3e7502649ec8db0d9847783a9c4,
title = "Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis",
abstract = " In patients with peritoneal carcinomatosis cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a promising treatment strategy. Here, we studied the role of hyperthermic chemotherapy on heat shock protein (HSP) expression and induction of tumor cell death and survival. HSP27, HSP70, and HSP90 combined with effects on tumor cell proliferation and chemosensitivity were analyzed in human colon cancer. Hyperthermic chemotherapy resulted in significant HSP27/HSP70 and HSP90 gene/protein overexpression in analyzed HT-29/SW480/SW620 colon cancer cells and peritoneal metastases from patients displaying amplified expression of proliferation markers, proliferating cell nuclear antigen and antiapoptotic protein Bcl-xL. Moreover, functionally increased chemoresistance against 5-fluorouracil/mitomycin C and oxaliplatin after hyperthermic chemotherapy points to induced survival mechanisms in cancer cells. In conclusion, the results indicate that intracellular HSP-associated antiapoptotic and proliferative effects after hyperthermic chemotherapy negatively influence beneficial effects of hyperthermic chemotherapy-induced cell death. Therefore, blocking HSPs could be a promising strategy to further improve the rate of tumor cell death and outcome of patients undergoing HIPEC therapy.",
keywords = "Heat shock proteins, peritoneal carcinomatosis, hyperthermic intraperitoneal chemotherapy, hyperthermia, apoptosis, chemoresistance",
author = "Tanja Grimmig and Eva-Maria Moll and Kerstin Kloos and Rebecca Thumm and Romana Moench and Simone Callies and Jennifer Kreckel and Malte Vetterlein and Joerg Pelz and Buelent Polat and Sudipta Tripathi and Roberta Rehder and Ribas, {Carmen M} and Anil Chandraker and Christoph-T Germer and Waaga-Gasser, {Ana Maria} and Martin Gasser",
year = "2017",
month = sep,
day = "18",
doi = "10.1177/1179064417730559",
language = "English",
pages = "1179064417730559",
journal = "Cancer Growth and Metastasis",
issn = "1179-0644",
number = "10",

}

RIS

TY - JOUR

T1 - Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis

AU - Grimmig, Tanja

AU - Moll, Eva-Maria

AU - Kloos, Kerstin

AU - Thumm, Rebecca

AU - Moench, Romana

AU - Callies, Simone

AU - Kreckel, Jennifer

AU - Vetterlein, Malte

AU - Pelz, Joerg

AU - Polat, Buelent

AU - Tripathi, Sudipta

AU - Rehder, Roberta

AU - Ribas, Carmen M

AU - Chandraker, Anil

AU - Germer, Christoph-T

AU - Waaga-Gasser, Ana Maria

AU - Gasser, Martin

PY - 2017/9/18

Y1 - 2017/9/18

N2 - In patients with peritoneal carcinomatosis cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a promising treatment strategy. Here, we studied the role of hyperthermic chemotherapy on heat shock protein (HSP) expression and induction of tumor cell death and survival. HSP27, HSP70, and HSP90 combined with effects on tumor cell proliferation and chemosensitivity were analyzed in human colon cancer. Hyperthermic chemotherapy resulted in significant HSP27/HSP70 and HSP90 gene/protein overexpression in analyzed HT-29/SW480/SW620 colon cancer cells and peritoneal metastases from patients displaying amplified expression of proliferation markers, proliferating cell nuclear antigen and antiapoptotic protein Bcl-xL. Moreover, functionally increased chemoresistance against 5-fluorouracil/mitomycin C and oxaliplatin after hyperthermic chemotherapy points to induced survival mechanisms in cancer cells. In conclusion, the results indicate that intracellular HSP-associated antiapoptotic and proliferative effects after hyperthermic chemotherapy negatively influence beneficial effects of hyperthermic chemotherapy-induced cell death. Therefore, blocking HSPs could be a promising strategy to further improve the rate of tumor cell death and outcome of patients undergoing HIPEC therapy.

AB - In patients with peritoneal carcinomatosis cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) represents a promising treatment strategy. Here, we studied the role of hyperthermic chemotherapy on heat shock protein (HSP) expression and induction of tumor cell death and survival. HSP27, HSP70, and HSP90 combined with effects on tumor cell proliferation and chemosensitivity were analyzed in human colon cancer. Hyperthermic chemotherapy resulted in significant HSP27/HSP70 and HSP90 gene/protein overexpression in analyzed HT-29/SW480/SW620 colon cancer cells and peritoneal metastases from patients displaying amplified expression of proliferation markers, proliferating cell nuclear antigen and antiapoptotic protein Bcl-xL. Moreover, functionally increased chemoresistance against 5-fluorouracil/mitomycin C and oxaliplatin after hyperthermic chemotherapy points to induced survival mechanisms in cancer cells. In conclusion, the results indicate that intracellular HSP-associated antiapoptotic and proliferative effects after hyperthermic chemotherapy negatively influence beneficial effects of hyperthermic chemotherapy-induced cell death. Therefore, blocking HSPs could be a promising strategy to further improve the rate of tumor cell death and outcome of patients undergoing HIPEC therapy.

KW - Heat shock proteins, peritoneal carcinomatosis, hyperthermic intraperitoneal chemotherapy, hyperthermia, apoptosis, chemoresistance

U2 - 10.1177/1179064417730559

DO - 10.1177/1179064417730559

M3 - SCORING: Journal article

SP - 1179064417730559

JO - Cancer Growth and Metastasis

JF - Cancer Growth and Metastasis

SN - 1179-0644

IS - 10

ER -