Upper and/or lower respiratory tract infection caused by human metapneumovirus after allogeneic hematopoietic stem cell transplantation
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Upper and/or lower respiratory tract infection caused by human metapneumovirus after allogeneic hematopoietic stem cell transplantation. / Piñana, Jose Luis; Tridello, Gloria; Xhaard, Aliénor; Wendel, Lotus; Montoro, Juan; Vazquez, Lourdes; Heras, Inmaculada; Ljungman, Per; Mikulska, Malgorzata; Salmenniemi, Urpu; Perez, Ariadna; Kröger, Nicolaus; Cornelissen, J J; Sala, Elisa; Martino, Rodrigo; Geurten, Claire; Byrne, Jenny; Maertens, Johan; Kerre, Tessa; Martin, Murray; Pascual, Maria Jesús; Yeshurun, Moshe; Finke, Jürgen; Groll, Andreas H; Shaw, Peter J; Blijlevens, Nicole; Arcese, William; Ganser, Arnold; Suarez-Lledo, Maria; Alzahrani, Mohsen; Choi, Goda; Forcade, Edouard; Paviglianiti, Annalisa; Solano, Carlos; Wachowiak, Jacek; Zuckerman, Tsila; Bader, Peter; Clausen, Johannes; Mayer, Jiri; Schroyens, Wilfried; Metafuni, Elisabetta; Knelange, Nina; Averbuch, Dina; de la Camara, Rafael.
in: J INFECT DIS, Jahrgang 229, Nr. 1, 12.01.2024, S. 83-94.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Upper and/or lower respiratory tract infection caused by human metapneumovirus after allogeneic hematopoietic stem cell transplantation
AU - Piñana, Jose Luis
AU - Tridello, Gloria
AU - Xhaard, Aliénor
AU - Wendel, Lotus
AU - Montoro, Juan
AU - Vazquez, Lourdes
AU - Heras, Inmaculada
AU - Ljungman, Per
AU - Mikulska, Malgorzata
AU - Salmenniemi, Urpu
AU - Perez, Ariadna
AU - Kröger, Nicolaus
AU - Cornelissen, J J
AU - Sala, Elisa
AU - Martino, Rodrigo
AU - Geurten, Claire
AU - Byrne, Jenny
AU - Maertens, Johan
AU - Kerre, Tessa
AU - Martin, Murray
AU - Pascual, Maria Jesús
AU - Yeshurun, Moshe
AU - Finke, Jürgen
AU - Groll, Andreas H
AU - Shaw, Peter J
AU - Blijlevens, Nicole
AU - Arcese, William
AU - Ganser, Arnold
AU - Suarez-Lledo, Maria
AU - Alzahrani, Mohsen
AU - Choi, Goda
AU - Forcade, Edouard
AU - Paviglianiti, Annalisa
AU - Solano, Carlos
AU - Wachowiak, Jacek
AU - Zuckerman, Tsila
AU - Bader, Peter
AU - Clausen, Johannes
AU - Mayer, Jiri
AU - Schroyens, Wilfried
AU - Metafuni, Elisabetta
AU - Knelange, Nina
AU - Averbuch, Dina
AU - de la Camara, Rafael
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2024/1/12
Y1 - 2024/1/12
N2 - BACKGROUND: Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area.METHODS: This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT.RESULTS: We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases.CONCLUSIONS: These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.
AB - BACKGROUND: Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area.METHODS: This retrospective multicenter cohort study examined the epidemiology, clinical characteristics, and risk factors for poor outcomes associated with human metapneumovirus (hMPV) infections in recipients of allo-HCT.RESULTS: We included 428 allo-HCT recipients who developed 438 hMPV infection episodes between January 2012 and January 2019. Most recipients were adults (93%). hMPV infections were diagnosed at a median of 373 days after allo-HCT. The infections were categorized as upper respiratory tract disease (URTD) or lower respiratory tract disease (LRTD), with 60% and 40% of cases, respectively. Patients with hMPV LRTD experienced the infection earlier in the transplant course and had higher rates of lymphopenia, neutropenia, corticosteroid use, and ribavirin therapy. Multivariate analysis identified lymphopenia and corticosteroid use (>30 mg/d) as independent risk factors for LRTD occurrence. The overall mortality at day 30 after hMPV detection was 2% for URTD, 12% for possible LRTD, and 21% for proven LRTD. Lymphopenia was the only independent risk factor associated with day 30 mortality in LRTD cases.CONCLUSIONS: These findings highlight the significance of lymphopenia and corticosteroid use in the development and severity of hMPV infections after allo-HCT, with lymphopenia being a predictor of higher mortality in LRTD cases.
U2 - 10.1093/infdis/jiad268
DO - 10.1093/infdis/jiad268
M3 - SCORING: Journal article
C2 - 37440459
VL - 229
SP - 83
EP - 94
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 1
ER -
