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Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer

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Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer. / Steurer, Stefan; Hager, Benjamin; Büscheck, Franziska; Höflmayer, Doris; Tsourlakis, Maria Christina; Minner, Sarah; Clauditz, Till S; Hube-Magg, Claudia; Luebke, Andreas M; Simon, Ronald; Izbicki, Jakob R; Burandt, Eike; Sauter, Guido; Fraune, Christoph; Weidemann, Sören; Schlomm, Thorsten; Heinzer, Hans; Haese, Alexander; Graefen, Markus; Huland, Hartwig; Heumann, Asmus.

in: AGING-US, Jahrgang 11, Nr. 18, 25.09.2019, S. 7859-7879.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Steurer, S, Hager, B, Büscheck, F, Höflmayer, D, Tsourlakis, MC, Minner, S, Clauditz, TS, Hube-Magg, C, Luebke, AM, Simon, R, Izbicki, JR, Burandt, E, Sauter, G, Fraune, C, Weidemann, S, Schlomm, T, Heinzer, H, Haese, A, Graefen, M, Huland, H & Heumann, A 2019, 'Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer', AGING-US, Jg. 11, Nr. 18, S. 7859-7879. https://doi.org/10.18632/aging.102294

APA

Steurer, S., Hager, B., Büscheck, F., Höflmayer, D., Tsourlakis, M. C., Minner, S., Clauditz, T. S., Hube-Magg, C., Luebke, A. M., Simon, R., Izbicki, J. R., Burandt, E., Sauter, G., Fraune, C., Weidemann, S., Schlomm, T., Heinzer, H., Haese, A., Graefen, M., ... Heumann, A. (2019). Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer. AGING-US, 11(18), 7859-7879. https://doi.org/10.18632/aging.102294

Vancouver

Steurer S, Hager B, Büscheck F, Höflmayer D, Tsourlakis MC, Minner S et al. Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer. AGING-US. 2019 Sep 25;11(18):7859-7879. https://doi.org/10.18632/aging.102294

Bibtex

@article{77a4111a3d3b4513a18c11480335c05e,
title = "Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer",
abstract = "BACKGROUND AND OBJECTIVES: Overexpression of the cytoskeleton-modulating kinase ROCK1 has been associated with unfavorable outcome in many cancers, but its impact in prostate cancer is largely unknown.RESULTS: A weak ROCK1 staining was found in >90% of normal, and cancerous prostate tissues, but was generally stronger in cancer cells as compared to adjacent normal glands. In cancer, ROCK1 staining was considered weak, moderate, and strong in 22%, 53%, and 18% of cases respectively. Higher ROCK1 expression levels were associated with tumor stage, and Gleason grade, positive nodal stage, positive surgical margin, accelerated cell proliferation and early PSA recurrence in multivariable analysis. ROCK1 up regulation was associated with androgen receptor (AR) expression, TMPRSS2:ERG fusion, genomic deletions of the PTEN tumor suppressor, as well as recurrent deletions at chromosomes 3p, 5q, 6q. Strong ROCK1 staining was found in 3% of AR-negative, but in 27% of strongly AR positive cancers, in 13% of ERG-negative but in 25% of ERG positive cancers, and in 12% of PTEN normal but in 26% of PTEN deleted cancers.CONCLUSIONS: This study identifies ROCK1 expression associated with prognosis in prostate cancer.METHODS: We tested ROCK1 expression in 12 427 prostate cancer specimens and followed PSA recurrence after prostatectomy.",
author = "Stefan Steurer and Benjamin Hager and Franziska B{\"u}scheck and Doris H{\"o}flmayer and Tsourlakis, {Maria Christina} and Sarah Minner and Clauditz, {Till S} and Claudia Hube-Magg and Luebke, {Andreas M} and Ronald Simon and Izbicki, {Jakob R} and Eike Burandt and Guido Sauter and Christoph Fraune and S{\"o}ren Weidemann and Thorsten Schlomm and Hans Heinzer and Alexander Haese and Markus Graefen and Hartwig Huland and Asmus Heumann",
year = "2019",
month = sep,
day = "25",
doi = "10.18632/aging.102294",
language = "English",
volume = "11",
pages = "7859--7879",
journal = "AGING-US",
issn = "1945-4589",
publisher = "US Administration on Aging",
number = "18",

}

RIS

TY - JOUR

T1 - Up regulation of Rho-associated coiled-coil containing kinase1 (ROCK1) is associated with genetic instability and poor prognosis in prostate cancer

AU - Steurer, Stefan

AU - Hager, Benjamin

AU - Büscheck, Franziska

AU - Höflmayer, Doris

AU - Tsourlakis, Maria Christina

AU - Minner, Sarah

AU - Clauditz, Till S

AU - Hube-Magg, Claudia

AU - Luebke, Andreas M

AU - Simon, Ronald

AU - Izbicki, Jakob R

AU - Burandt, Eike

AU - Sauter, Guido

AU - Fraune, Christoph

AU - Weidemann, Sören

AU - Schlomm, Thorsten

AU - Heinzer, Hans

AU - Haese, Alexander

AU - Graefen, Markus

AU - Huland, Hartwig

AU - Heumann, Asmus

PY - 2019/9/25

Y1 - 2019/9/25

N2 - BACKGROUND AND OBJECTIVES: Overexpression of the cytoskeleton-modulating kinase ROCK1 has been associated with unfavorable outcome in many cancers, but its impact in prostate cancer is largely unknown.RESULTS: A weak ROCK1 staining was found in >90% of normal, and cancerous prostate tissues, but was generally stronger in cancer cells as compared to adjacent normal glands. In cancer, ROCK1 staining was considered weak, moderate, and strong in 22%, 53%, and 18% of cases respectively. Higher ROCK1 expression levels were associated with tumor stage, and Gleason grade, positive nodal stage, positive surgical margin, accelerated cell proliferation and early PSA recurrence in multivariable analysis. ROCK1 up regulation was associated with androgen receptor (AR) expression, TMPRSS2:ERG fusion, genomic deletions of the PTEN tumor suppressor, as well as recurrent deletions at chromosomes 3p, 5q, 6q. Strong ROCK1 staining was found in 3% of AR-negative, but in 27% of strongly AR positive cancers, in 13% of ERG-negative but in 25% of ERG positive cancers, and in 12% of PTEN normal but in 26% of PTEN deleted cancers.CONCLUSIONS: This study identifies ROCK1 expression associated with prognosis in prostate cancer.METHODS: We tested ROCK1 expression in 12 427 prostate cancer specimens and followed PSA recurrence after prostatectomy.

AB - BACKGROUND AND OBJECTIVES: Overexpression of the cytoskeleton-modulating kinase ROCK1 has been associated with unfavorable outcome in many cancers, but its impact in prostate cancer is largely unknown.RESULTS: A weak ROCK1 staining was found in >90% of normal, and cancerous prostate tissues, but was generally stronger in cancer cells as compared to adjacent normal glands. In cancer, ROCK1 staining was considered weak, moderate, and strong in 22%, 53%, and 18% of cases respectively. Higher ROCK1 expression levels were associated with tumor stage, and Gleason grade, positive nodal stage, positive surgical margin, accelerated cell proliferation and early PSA recurrence in multivariable analysis. ROCK1 up regulation was associated with androgen receptor (AR) expression, TMPRSS2:ERG fusion, genomic deletions of the PTEN tumor suppressor, as well as recurrent deletions at chromosomes 3p, 5q, 6q. Strong ROCK1 staining was found in 3% of AR-negative, but in 27% of strongly AR positive cancers, in 13% of ERG-negative but in 25% of ERG positive cancers, and in 12% of PTEN normal but in 26% of PTEN deleted cancers.CONCLUSIONS: This study identifies ROCK1 expression associated with prognosis in prostate cancer.METHODS: We tested ROCK1 expression in 12 427 prostate cancer specimens and followed PSA recurrence after prostatectomy.

U2 - 10.18632/aging.102294

DO - 10.18632/aging.102294

M3 - SCORING: Journal article

C2 - 31557128

VL - 11

SP - 7859

EP - 7879

JO - AGING-US

JF - AGING-US

SN - 1945-4589

IS - 18

ER -