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Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging

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Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging. / Albrecht, Franziska; Mueller, Karsten; Ballarini, Tommaso; Lampe, Leonie; Diehl-Schmid, Janine; Fassbender, Klaus; Fliessbach, Klaus; Jahn, Holger; Jech, Robert; Kassubek, Jan; Kornhuber, Johannes; Landwehrmeyer, Bernhard; Lauer, Martin; Ludolph, Albert C; Lyros, Epameinondas; Prudlo, Johannes; Schneider, Anja; Synofzik, Matthis; Wiltfang, Jens; Danek, Adrian; Otto, Markus; Schroeter, Matthias L; FTLD consortium.

in: CORTEX, Jahrgang 117, 08.2019, S. 33-40.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Albrecht, F, Mueller, K, Ballarini, T, Lampe, L, Diehl-Schmid, J, Fassbender, K, Fliessbach, K, Jahn, H, Jech, R, Kassubek, J, Kornhuber, J, Landwehrmeyer, B, Lauer, M, Ludolph, AC, Lyros, E, Prudlo, J, Schneider, A, Synofzik, M, Wiltfang, J, Danek, A, Otto, M, Schroeter, ML & FTLD consortium 2019, 'Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging', CORTEX, Jg. 117, S. 33-40.

APA

Albrecht, F., Mueller, K., Ballarini, T., Lampe, L., Diehl-Schmid, J., Fassbender, K., Fliessbach, K., Jahn, H., Jech, R., Kassubek, J., Kornhuber, J., Landwehrmeyer, B., Lauer, M., Ludolph, A. C., Lyros, E., Prudlo, J., Schneider, A., Synofzik, M., Wiltfang, J., ... FTLD consortium (2019). Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging. CORTEX, 117, 33-40.

Vancouver

Albrecht F, Mueller K, Ballarini T, Lampe L, Diehl-Schmid J, Fassbender K et al. Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging. CORTEX. 2019 Aug;117:33-40.

Bibtex

@article{2a28598d87c54c5d9732e9d519eaac8b,
title = "Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging",
abstract = "Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.",
author = "Franziska Albrecht and Karsten Mueller and Tommaso Ballarini and Leonie Lampe and Janine Diehl-Schmid and Klaus Fassbender and Klaus Fliessbach and Holger Jahn and Robert Jech and Jan Kassubek and Johannes Kornhuber and Bernhard Landwehrmeyer and Martin Lauer and Ludolph, {Albert C} and Epameinondas Lyros and Johannes Prudlo and Anja Schneider and Matthis Synofzik and Jens Wiltfang and Adrian Danek and Markus Otto and Schroeter, {Matthias L} and {FTLD consortium}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2019",
month = aug,
language = "English",
volume = "117",
pages = "33--40",
journal = "CORTEX",
issn = "0010-9452",
publisher = "Masson SpA",

}

RIS

TY - JOUR

T1 - Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging

AU - Albrecht, Franziska

AU - Mueller, Karsten

AU - Ballarini, Tommaso

AU - Lampe, Leonie

AU - Diehl-Schmid, Janine

AU - Fassbender, Klaus

AU - Fliessbach, Klaus

AU - Jahn, Holger

AU - Jech, Robert

AU - Kassubek, Jan

AU - Kornhuber, Johannes

AU - Landwehrmeyer, Bernhard

AU - Lauer, Martin

AU - Ludolph, Albert C

AU - Lyros, Epameinondas

AU - Prudlo, Johannes

AU - Schneider, Anja

AU - Synofzik, Matthis

AU - Wiltfang, Jens

AU - Danek, Adrian

AU - Otto, Markus

AU - Schroeter, Matthias L

AU - FTLD consortium

N1 - Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2019/8

Y1 - 2019/8

N2 - Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.

AB - Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.

M3 - SCORING: Journal article

C2 - 30927559

VL - 117

SP - 33

EP - 40

JO - CORTEX

JF - CORTEX

SN - 0010-9452

ER -