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Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock

Standard

Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock. / Schrage, Benedikt; Burkhoff, Daniel; Rübsamen, Nicole; Becher, Peter Moritz; Schwarzl, Michael; Bernhardt, Alexander; Grahn, Hanno; Lubos, Edith; Söffker, Gerold; Clemmensen, Peter; Reichenspurner, Hermann; Blankenberg, Stefan; Westermann, Dirk.

in: JACC-HEART FAIL, Jahrgang 6, Nr. 12, 12.2018, S. 1035-1043.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schrage, B, Burkhoff, D, Rübsamen, N, Becher, PM, Schwarzl, M, Bernhardt, A, Grahn, H, Lubos, E, Söffker, G, Clemmensen, P, Reichenspurner, H, Blankenberg, S & Westermann, D 2018, 'Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock', JACC-HEART FAIL, Jg. 6, Nr. 12, S. 1035-1043. https://doi.org/10.1016/j.jchf.2018.09.009

APA

Schrage, B., Burkhoff, D., Rübsamen, N., Becher, P. M., Schwarzl, M., Bernhardt, A., Grahn, H., Lubos, E., Söffker, G., Clemmensen, P., Reichenspurner, H., Blankenberg, S., & Westermann, D. (2018). Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock. JACC-HEART FAIL, 6(12), 1035-1043. https://doi.org/10.1016/j.jchf.2018.09.009

Vancouver

Schrage B, Burkhoff D, Rübsamen N, Becher PM, Schwarzl M, Bernhardt A et al. Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock. JACC-HEART FAIL. 2018 Dez;6(12):1035-1043. https://doi.org/10.1016/j.jchf.2018.09.009

Bibtex

@article{f1b8df0285a64ca8ac1a2e9d08b7baa3,
title = "Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock",
abstract = "OBJECTIVES: This report relates the authors' ongoing experience with percutaneous left ventricular (LV) unloading by using a transaortic LV assist device in combination with venoarterial extracorporeal membrane oxygenation (VA-ECMO) and provides an in-depth analysis of the hemodynamic benefit of this approach.BACKGROUND: VA-ECMO is increasingly used in cases of severe cardiogenic shock. However, increase in afterload with subsequent LV overload is a major drawback of VA-ECMO.METHODS: Consecutive patients were treated with a transaortic LV assist device in addition to VA-ECMO for cardiogenic shock. The primary endpoint was 30-day all-cause mortality. Additional endpoints included weaning from VA-ECMO and safety endpoints.RESULTS: Between September 2013 and January 2018, 106 patients were treated with percutaneous LV unloading, using a transaortic LV assist device in combination with VA-ECMO. Successful weaning from VA-ECMO support was achieved in 51.9% of all patients. In the overall cohort, survival at day 30 was 35.8%, which was higher than predicted by the SAVE score (20%) or by the SAPS-II score (6.9%). Right heart catheterization indicated a marked decrease of PCWP after addition of the device to VA-ECMO.CONCLUSIONS: The strategy of percutaneous LV unloading using a transaortic LV assist device in combination with VA-ECMO improved outcome in an all-comers cohort compared to established risk scores. A prospective, randomized study is needed to further investigate this approach.",
keywords = "Journal Article",
author = "Benedikt Schrage and Daniel Burkhoff and Nicole R{\"u}bsamen and Becher, {Peter Moritz} and Michael Schwarzl and Alexander Bernhardt and Hanno Grahn and Edith Lubos and Gerold S{\"o}ffker and Peter Clemmensen and Hermann Reichenspurner and Stefan Blankenberg and Dirk Westermann",
note = "Copyright {\textcopyright} 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = dec,
doi = "10.1016/j.jchf.2018.09.009",
language = "English",
volume = "6",
pages = "1035--1043",
journal = "JACC-HEART FAIL",
issn = "2213-1779",
publisher = "Elsevier BV",
number = "12",

}

RIS

TY - JOUR

T1 - Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock

AU - Schrage, Benedikt

AU - Burkhoff, Daniel

AU - Rübsamen, Nicole

AU - Becher, Peter Moritz

AU - Schwarzl, Michael

AU - Bernhardt, Alexander

AU - Grahn, Hanno

AU - Lubos, Edith

AU - Söffker, Gerold

AU - Clemmensen, Peter

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Westermann, Dirk

N1 - Copyright © 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVES: This report relates the authors' ongoing experience with percutaneous left ventricular (LV) unloading by using a transaortic LV assist device in combination with venoarterial extracorporeal membrane oxygenation (VA-ECMO) and provides an in-depth analysis of the hemodynamic benefit of this approach.BACKGROUND: VA-ECMO is increasingly used in cases of severe cardiogenic shock. However, increase in afterload with subsequent LV overload is a major drawback of VA-ECMO.METHODS: Consecutive patients were treated with a transaortic LV assist device in addition to VA-ECMO for cardiogenic shock. The primary endpoint was 30-day all-cause mortality. Additional endpoints included weaning from VA-ECMO and safety endpoints.RESULTS: Between September 2013 and January 2018, 106 patients were treated with percutaneous LV unloading, using a transaortic LV assist device in combination with VA-ECMO. Successful weaning from VA-ECMO support was achieved in 51.9% of all patients. In the overall cohort, survival at day 30 was 35.8%, which was higher than predicted by the SAVE score (20%) or by the SAPS-II score (6.9%). Right heart catheterization indicated a marked decrease of PCWP after addition of the device to VA-ECMO.CONCLUSIONS: The strategy of percutaneous LV unloading using a transaortic LV assist device in combination with VA-ECMO improved outcome in an all-comers cohort compared to established risk scores. A prospective, randomized study is needed to further investigate this approach.

AB - OBJECTIVES: This report relates the authors' ongoing experience with percutaneous left ventricular (LV) unloading by using a transaortic LV assist device in combination with venoarterial extracorporeal membrane oxygenation (VA-ECMO) and provides an in-depth analysis of the hemodynamic benefit of this approach.BACKGROUND: VA-ECMO is increasingly used in cases of severe cardiogenic shock. However, increase in afterload with subsequent LV overload is a major drawback of VA-ECMO.METHODS: Consecutive patients were treated with a transaortic LV assist device in addition to VA-ECMO for cardiogenic shock. The primary endpoint was 30-day all-cause mortality. Additional endpoints included weaning from VA-ECMO and safety endpoints.RESULTS: Between September 2013 and January 2018, 106 patients were treated with percutaneous LV unloading, using a transaortic LV assist device in combination with VA-ECMO. Successful weaning from VA-ECMO support was achieved in 51.9% of all patients. In the overall cohort, survival at day 30 was 35.8%, which was higher than predicted by the SAVE score (20%) or by the SAPS-II score (6.9%). Right heart catheterization indicated a marked decrease of PCWP after addition of the device to VA-ECMO.CONCLUSIONS: The strategy of percutaneous LV unloading using a transaortic LV assist device in combination with VA-ECMO improved outcome in an all-comers cohort compared to established risk scores. A prospective, randomized study is needed to further investigate this approach.

KW - Journal Article

U2 - 10.1016/j.jchf.2018.09.009

DO - 10.1016/j.jchf.2018.09.009

M3 - SCORING: Journal article

C2 - 30497643

VL - 6

SP - 1035

EP - 1043

JO - JACC-HEART FAIL

JF - JACC-HEART FAIL

SN - 2213-1779

IS - 12

ER -