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Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review

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Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. / Blohm, Martin E G; Göbel, Ulrich.

in: EUR J PEDIATR, Jahrgang 163, Nr. 1, 01.2004, S. 1-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Blohm, MEG & Göbel, U 2004, 'Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review', EUR J PEDIATR, Jg. 163, Nr. 1, S. 1-6. https://doi.org/10.1007/s00431-003-1361-1

APA

Blohm, M. E. G., & Göbel, U. (2004). Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. EUR J PEDIATR, 163(1), 1-6. https://doi.org/10.1007/s00431-003-1361-1

Vancouver

Blohm MEG, Göbel U. Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review. EUR J PEDIATR. 2004 Jan;163(1):1-6. https://doi.org/10.1007/s00431-003-1361-1

Bibtex

@article{64a858e46b52428aad6fccffc51c8691,
title = "Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review",
abstract = "UNLABELLED: Infantile choriocarcinoma is a highly malignant germ cell tumour sub-entity thought to originate from the placenta. The aim of this review is to alert clinicians to clinical symptoms and course of neonatal/infantile choriocarcinoma in order to improve the prognosis of affected children by early diagnosis and appropriate treatment. The clinical details of all 30 cases according to a Medline literature search including two cases documented in the MAKEI germ cell tumour study are analysed. Children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months). Typical early symptoms with decreasing incidence are anaemia, failure to thrive, hepatomegaly, haemoptysis or respiratory failure, there may be signs of precocious puberty. The tumour affected more than one organ in most cases; organs involved were liver (23/30 cases, 77%), lung (20/30, 67%), brain (8/30, 27%), or skin (3/30, 10%). The natural disease course is rapidly fatal. Without appropriate anti-neoplastic treatment, infantile death occurs on average within 3 weeks from first presentation with a high rate of post-mortem diagnoses (9/28, 32% of live born infants). In recent years, five reported patients (5/30, 18%) achieved a sustained remission after multi-agent cisplatinum-based chemotherapy and delayed (4/5) or primary tumour resection (1/5). beta-Human chorionic gonadotropin was universally elevated in 19/19 tested infants. Maternal choriocarcinoma was reported in 17 of the 30 cases.CONCLUSION: The differential diagnosis of infantile anaemia, failure to thrive and liver enlargement should include infantile choriocarcinoma and prompt measurement of beta-human chorionic gonadotropin.",
keywords = "Anemia/etiology, Choriocarcinoma/blood, Chorionic Gonadotropin, beta Subunit, Human/blood, Combined Modality Therapy, Diagnosis, Differential, Failure to Thrive/etiology, Female, Hepatomegaly/etiology, Humans, Infant, Infant, Newborn, Male, Placenta Diseases, Pregnancy, Treatment Outcome, Uterine Neoplasms/blood",
author = "Blohm, {Martin E G} and Ulrich G{\"o}bel",
year = "2004",
month = jan,
doi = "10.1007/s00431-003-1361-1",
language = "English",
volume = "163",
pages = "1--6",
journal = "EUR J PEDIATR",
issn = "0340-6199",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Unexplained anaemia and failure to thrive as initial symptoms of infantile choriocarcinoma: a review

AU - Blohm, Martin E G

AU - Göbel, Ulrich

PY - 2004/1

Y1 - 2004/1

N2 - UNLABELLED: Infantile choriocarcinoma is a highly malignant germ cell tumour sub-entity thought to originate from the placenta. The aim of this review is to alert clinicians to clinical symptoms and course of neonatal/infantile choriocarcinoma in order to improve the prognosis of affected children by early diagnosis and appropriate treatment. The clinical details of all 30 cases according to a Medline literature search including two cases documented in the MAKEI germ cell tumour study are analysed. Children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months). Typical early symptoms with decreasing incidence are anaemia, failure to thrive, hepatomegaly, haemoptysis or respiratory failure, there may be signs of precocious puberty. The tumour affected more than one organ in most cases; organs involved were liver (23/30 cases, 77%), lung (20/30, 67%), brain (8/30, 27%), or skin (3/30, 10%). The natural disease course is rapidly fatal. Without appropriate anti-neoplastic treatment, infantile death occurs on average within 3 weeks from first presentation with a high rate of post-mortem diagnoses (9/28, 32% of live born infants). In recent years, five reported patients (5/30, 18%) achieved a sustained remission after multi-agent cisplatinum-based chemotherapy and delayed (4/5) or primary tumour resection (1/5). beta-Human chorionic gonadotropin was universally elevated in 19/19 tested infants. Maternal choriocarcinoma was reported in 17 of the 30 cases.CONCLUSION: The differential diagnosis of infantile anaemia, failure to thrive and liver enlargement should include infantile choriocarcinoma and prompt measurement of beta-human chorionic gonadotropin.

AB - UNLABELLED: Infantile choriocarcinoma is a highly malignant germ cell tumour sub-entity thought to originate from the placenta. The aim of this review is to alert clinicians to clinical symptoms and course of neonatal/infantile choriocarcinoma in order to improve the prognosis of affected children by early diagnosis and appropriate treatment. The clinical details of all 30 cases according to a Medline literature search including two cases documented in the MAKEI germ cell tumour study are analysed. Children suffering from infantile choriocarcinoma become symptomatic at a median age of 1 month (range 0 days-5 months). Typical early symptoms with decreasing incidence are anaemia, failure to thrive, hepatomegaly, haemoptysis or respiratory failure, there may be signs of precocious puberty. The tumour affected more than one organ in most cases; organs involved were liver (23/30 cases, 77%), lung (20/30, 67%), brain (8/30, 27%), or skin (3/30, 10%). The natural disease course is rapidly fatal. Without appropriate anti-neoplastic treatment, infantile death occurs on average within 3 weeks from first presentation with a high rate of post-mortem diagnoses (9/28, 32% of live born infants). In recent years, five reported patients (5/30, 18%) achieved a sustained remission after multi-agent cisplatinum-based chemotherapy and delayed (4/5) or primary tumour resection (1/5). beta-Human chorionic gonadotropin was universally elevated in 19/19 tested infants. Maternal choriocarcinoma was reported in 17 of the 30 cases.CONCLUSION: The differential diagnosis of infantile anaemia, failure to thrive and liver enlargement should include infantile choriocarcinoma and prompt measurement of beta-human chorionic gonadotropin.

KW - Anemia/etiology

KW - Choriocarcinoma/blood

KW - Chorionic Gonadotropin, beta Subunit, Human/blood

KW - Combined Modality Therapy

KW - Diagnosis, Differential

KW - Failure to Thrive/etiology

KW - Female

KW - Hepatomegaly/etiology

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Placenta Diseases

KW - Pregnancy

KW - Treatment Outcome

KW - Uterine Neoplasms/blood

U2 - 10.1007/s00431-003-1361-1

DO - 10.1007/s00431-003-1361-1

M3 - SCORING: Review article

C2 - 14628141

VL - 163

SP - 1

EP - 6

JO - EUR J PEDIATR

JF - EUR J PEDIATR

SN - 0340-6199

IS - 1

ER -