Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancer.
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Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancer. / Blonski, Katharina; Milde-Langosch, Karin; Bamberger, Ana-Maria; Osterholz, Tina; Utler, Christian; Berger, Jürgen; Löning, Thomas; Schumacher, Udo.
in: ANTICANCER RES, Jahrgang 27, Nr. 4, 4, 2007, S. 2785-2790.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Ulex europeus agglutinin-I binding as a potential prognostic marker in ovarian cancer.
AU - Blonski, Katharina
AU - Milde-Langosch, Karin
AU - Bamberger, Ana-Maria
AU - Osterholz, Tina
AU - Utler, Christian
AU - Berger, Jürgen
AU - Löning, Thomas
AU - Schumacher, Udo
PY - 2007
Y1 - 2007
N2 - BACKGROUND: Ovarian cancer represents the malignant tumour of the female genital tract with the worst prognosis, mainly caused by early intraperitoneal spread. Cell-to-cell and cell-to-matrix interactions play a functionally important role in this spread and are both mediated by the cell membrane. Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis. PATIENTS AND METHODS: The expression of lectin binding of 164 ovarian cancer patients was analysed and the staining results were correlated with the clinical data of the patients. Results: The univariate and multivariate statistical analysis revealed an independent prognostic significance for Ulex europeus agglutinin-I (UEA-I) binding. CONCLUSION: These findings indicate that UEA-I binding can serve as a prognostic factor in ovarian cancer.
AB - BACKGROUND: Ovarian cancer represents the malignant tumour of the female genital tract with the worst prognosis, mainly caused by early intraperitoneal spread. Cell-to-cell and cell-to-matrix interactions play a functionally important role in this spread and are both mediated by the cell membrane. Changes in the glycosylation of the cell membrane, as detected by lectin histochemistry, are sometimes associated with a poor prognosis. PATIENTS AND METHODS: The expression of lectin binding of 164 ovarian cancer patients was analysed and the staining results were correlated with the clinical data of the patients. Results: The univariate and multivariate statistical analysis revealed an independent prognostic significance for Ulex europeus agglutinin-I (UEA-I) binding. CONCLUSION: These findings indicate that UEA-I binding can serve as a prognostic factor in ovarian cancer.
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 2785
EP - 2790
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 4
M1 - 4
ER -