Type III secretion systems shape up as they ship out.
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Type III secretion systems shape up as they ship out. / Marlovits, Thomas; Stebbins, C Erec.
in: CURR OPIN MICROBIOL, Jahrgang 13, Nr. 1, 1, 2010, S. 47-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Type III secretion systems shape up as they ship out.
AU - Marlovits, Thomas
AU - Stebbins, C Erec
PY - 2010
Y1 - 2010
N2 - Virulence associated protein type III secretion systems (T3SSs) are intricately structured organic nanosyringes that achieve the translocation of bacterial proteins from the prokaryotic cytoplasm across three membranes into the host cytosol. The substrates for these systems number in the hundreds, with remarkably diverse biological activities, modulating host cell biology for the benefit of the pathogen. Although there has been tremendous progress on the structure and function of the T3SS substrates, there has been comparatively little progress on the much more highly conserved secretion apparatus itself. This review summarizes recent advances in the field of structural microbiology that have begun to address this shortcoming, finally bringing to bear the power of structural biology to this central virulence system of Gram-negative bacterial pathogens.
AB - Virulence associated protein type III secretion systems (T3SSs) are intricately structured organic nanosyringes that achieve the translocation of bacterial proteins from the prokaryotic cytoplasm across three membranes into the host cytosol. The substrates for these systems number in the hundreds, with remarkably diverse biological activities, modulating host cell biology for the benefit of the pathogen. Although there has been tremendous progress on the structure and function of the T3SS substrates, there has been comparatively little progress on the much more highly conserved secretion apparatus itself. This review summarizes recent advances in the field of structural microbiology that have begun to address this shortcoming, finally bringing to bear the power of structural biology to this central virulence system of Gram-negative bacterial pathogens.
KW - Models, Biological
KW - Protein Binding
KW - Bacterial Proteins/chemistry/metabolism/ultrastructure
KW - Macromolecular Substances/chemistry/metabolism
KW - Membrane Transport Proteins/chemistry/metabolism/ultrastructure
KW - Models, Chemical
KW - Protein Folding
KW - Virulence Factors/metabolism
KW - Models, Biological
KW - Protein Binding
KW - Bacterial Proteins/chemistry/metabolism/ultrastructure
KW - Macromolecular Substances/chemistry/metabolism
KW - Membrane Transport Proteins/chemistry/metabolism/ultrastructure
KW - Models, Chemical
KW - Protein Folding
KW - Virulence Factors/metabolism
M3 - SCORING: Journal article
VL - 13
SP - 47
EP - 52
IS - 1
M1 - 1
ER -