Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries

David Brieger; Stuart J Pocock; Stefan Blankenberg; Ji Yan Chen; Mauricio G Cohen; Christopher B Granger; Richard Grieve; Jose C Nicolau; Tabassome Simon; Dirk Westermann; Satoshi Yasuda; John Gregson; Kirsten L Rennie; Katarina Hedman; Karolina Andersson Sundell; Shaun G Goodman

doi:10.1016/j.ijcard.2020.01.070

Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries

Standard

Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries. / Brieger, David; Pocock, Stuart J; Blankenberg, Stefan; Chen, Ji Yan; Cohen, Mauricio G; Granger, Christopher B; Grieve, Richard; Nicolau, Jose C; Simon, Tabassome; Westermann, Dirk; Yasuda, Satoshi; Gregson, John; Rennie, Kirsten L; Hedman, Katarina; Sundell, Karolina Andersson; Goodman, Shaun G.

in: INT J CARDIOL, Jahrgang 311, 15.07.2020, S. 7-14.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Brieger, D, Pocock, SJ, Blankenberg, S, Chen, JY, Cohen, MG, Granger, CB, Grieve, R, Nicolau, JC, Simon, T, Westermann, D, Yasuda, S, Gregson, J, Rennie, KL, Hedman, K, Sundell, KA & Goodman, SG 2020, 'Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries', INT J CARDIOL, Jg. 311, S. 7-14. https://doi.org/10.1016/j.ijcard.2020.01.070

APA

Brieger, D., Pocock, S. J., Blankenberg, S., Chen, J. Y., Cohen, M. G., Granger, C. B., Grieve, R., Nicolau, J. C., Simon, T., Westermann, D., Yasuda, S., Gregson, J., Rennie, K. L., Hedman, K., Sundell, K. A., & Goodman, S. G. (2020). Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries. INT J CARDIOL, 311, 7-14. https://doi.org/10.1016/j.ijcard.2020.01.070

Vancouver

Brieger D, Pocock SJ, Blankenberg S, Chen JY, Cohen MG, Granger CB et al. Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries. INT J CARDIOL. 2020 Jul 15;311:7-14. https://doi.org/10.1016/j.ijcard.2020.01.070

Bibtex

@article{eb33a065e7174ba6b303c124e451413d,

title = "Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries",

abstract = "BACKGROUND: Evidence is lacking on long-term outcomes in unselected patients surviving the first year following myocardial infarction (MI).METHODS AND RESULTS: The TIGRIS (long-Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients) prospective registry enrolled 9176 eligible patients aged ≥50 years, 1-3 years post-MI, from 25 countries. All had ≥1 risk factor: age ≥ 65 years, diabetes mellitus, second prior MI, multivessel coronary artery disease, chronic kidney disease (CKD). Primary outcome was a composite of MI, unstable angina with urgent revascularization, stroke, or all-cause death at 2-year follow-up. Bleeding requiring hospitalization was also recorded. 9027 patients (98.4%) provided follow-up data: the primary outcome occurred in 621 (7.0%), all-cause mortality in 295 (3.3%), and bleeding in 109 (1.2%) patients. Events accrued linearly over time. In multivariable analyses, qualifying risk factors were associated with increased risk of primary outcome (incidence rate ratio [RR] per 100 patient-years [95% confidence interval]): CKD 2.06 (1.66, 2.55), second prior MI 1.71 (1.38, 2.10), diabetes mellitus 1.63 (1.39, 1.92), age ≥ 65 years 1.53 (1.28, 1.83), and multivessel disease 1.24 (1.05, 1.48). Risk of bleeding events was greater in older patients (vs <65 years) 65-74 years 2.68 (1.53, 4.70), ≥75 years 4.62 (2.57, 8.28), and those with CKD 1.99 (1.18, 3.35).CONCLUSION: In stable patients recruited 1-3 years post-MI, recurrent cardiovascular and bleeding events accrued linearly over 2 years. Factors independently predictive of ischemic and bleeding events were identified, providing a context for deciding on treatment options.",

keywords = "Aged, Coronary Artery Disease, Humans, Myocardial Infarction/diagnosis, Registries, Risk Factors, Stroke, Treatment Outcome",

author = "David Brieger and Pocock, {Stuart J} and Stefan Blankenberg and Chen, {Ji Yan} and Cohen, {Mauricio G} and Granger, {Christopher B} and Richard Grieve and Nicolau, {Jose C} and Tabassome Simon and Dirk Westermann and Satoshi Yasuda and John Gregson and Rennie, {Kirsten L} and Katarina Hedman and Sundell, {Karolina Andersson} and Goodman, {Shaun G}",

note = "Copyright {\textcopyright} 2020. Published by Elsevier B.V.",

year = "2020",

month = jul,

day = "15",

doi = "10.1016/j.ijcard.2020.01.070",

language = "English",

volume = "311",

pages = "7--14",

journal = "INT J CARDIOL",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries

AU - Brieger, David

AU - Pocock, Stuart J

AU - Blankenberg, Stefan

AU - Chen, Ji Yan

AU - Cohen, Mauricio G

AU - Granger, Christopher B

AU - Grieve, Richard

AU - Nicolau, Jose C

AU - Simon, Tabassome

AU - Westermann, Dirk

AU - Yasuda, Satoshi

AU - Gregson, John

AU - Rennie, Kirsten L

AU - Hedman, Katarina

AU - Sundell, Karolina Andersson

AU - Goodman, Shaun G

PY - 2020/7/15

Y1 - 2020/7/15

N2 - BACKGROUND: Evidence is lacking on long-term outcomes in unselected patients surviving the first year following myocardial infarction (MI).METHODS AND RESULTS: The TIGRIS (long-Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients) prospective registry enrolled 9176 eligible patients aged ≥50 years, 1-3 years post-MI, from 25 countries. All had ≥1 risk factor: age ≥ 65 years, diabetes mellitus, second prior MI, multivessel coronary artery disease, chronic kidney disease (CKD). Primary outcome was a composite of MI, unstable angina with urgent revascularization, stroke, or all-cause death at 2-year follow-up. Bleeding requiring hospitalization was also recorded. 9027 patients (98.4%) provided follow-up data: the primary outcome occurred in 621 (7.0%), all-cause mortality in 295 (3.3%), and bleeding in 109 (1.2%) patients. Events accrued linearly over time. In multivariable analyses, qualifying risk factors were associated with increased risk of primary outcome (incidence rate ratio [RR] per 100 patient-years [95% confidence interval]): CKD 2.06 (1.66, 2.55), second prior MI 1.71 (1.38, 2.10), diabetes mellitus 1.63 (1.39, 1.92), age ≥ 65 years 1.53 (1.28, 1.83), and multivessel disease 1.24 (1.05, 1.48). Risk of bleeding events was greater in older patients (vs <65 years) 65-74 years 2.68 (1.53, 4.70), ≥75 years 4.62 (2.57, 8.28), and those with CKD 1.99 (1.18, 3.35).CONCLUSION: In stable patients recruited 1-3 years post-MI, recurrent cardiovascular and bleeding events accrued linearly over 2 years. Factors independently predictive of ischemic and bleeding events were identified, providing a context for deciding on treatment options.

AB - BACKGROUND: Evidence is lacking on long-term outcomes in unselected patients surviving the first year following myocardial infarction (MI).METHODS AND RESULTS: The TIGRIS (long-Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients) prospective registry enrolled 9176 eligible patients aged ≥50 years, 1-3 years post-MI, from 25 countries. All had ≥1 risk factor: age ≥ 65 years, diabetes mellitus, second prior MI, multivessel coronary artery disease, chronic kidney disease (CKD). Primary outcome was a composite of MI, unstable angina with urgent revascularization, stroke, or all-cause death at 2-year follow-up. Bleeding requiring hospitalization was also recorded. 9027 patients (98.4%) provided follow-up data: the primary outcome occurred in 621 (7.0%), all-cause mortality in 295 (3.3%), and bleeding in 109 (1.2%) patients. Events accrued linearly over time. In multivariable analyses, qualifying risk factors were associated with increased risk of primary outcome (incidence rate ratio [RR] per 100 patient-years [95% confidence interval]): CKD 2.06 (1.66, 2.55), second prior MI 1.71 (1.38, 2.10), diabetes mellitus 1.63 (1.39, 1.92), age ≥ 65 years 1.53 (1.28, 1.83), and multivessel disease 1.24 (1.05, 1.48). Risk of bleeding events was greater in older patients (vs <65 years) 65-74 years 2.68 (1.53, 4.70), ≥75 years 4.62 (2.57, 8.28), and those with CKD 1.99 (1.18, 3.35).CONCLUSION: In stable patients recruited 1-3 years post-MI, recurrent cardiovascular and bleeding events accrued linearly over 2 years. Factors independently predictive of ischemic and bleeding events were identified, providing a context for deciding on treatment options.

KW - Aged

KW - Coronary Artery Disease

KW - Humans

KW - Myocardial Infarction/diagnosis

KW - Registries

KW - Risk Factors

KW - Stroke

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2020.01.070

DO - 10.1016/j.ijcard.2020.01.070

M3 - SCORING: Journal article

C2 - 32057476

VL - 311

SP - 7

EP - 14

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -