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Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes

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Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. / Benquet, Pascal; Gee, Christine E; Gerber, Urs.

in: J NEUROSCI, Jahrgang 22, Nr. 22, 15.11.2002, S. 9679-86.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Benquet, P, Gee, CE & Gerber, U 2002, 'Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes', J NEUROSCI, Jg. 22, Nr. 22, S. 9679-86.

APA

Benquet, P., Gee, C. E., & Gerber, U. (2002). Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. J NEUROSCI, 22(22), 9679-86.

Vancouver

Benquet P, Gee CE, Gerber U. Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes. J NEUROSCI. 2002 Nov 15;22(22):9679-86.

Bibtex

@article{a50b0985835c45e88e183fd958c54ab8,
title = "Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes",
abstract = "Molecular processes regulating the gain of NMDA receptors modulate diverse physiological and pathological responses in the CNS. Group I metabotropic glutamate receptors (mGluRs), which neighbor NMDA receptors and which can be coactivated by synaptically released glutamate, couple to several different second messenger pathways, each of which could target NMDA receptors. In CA3 pyramidal cells we show that the activation of mGluR1 potentiates NMDA current via a G-protein-independent mechanism involving Src kinase activation. In contrast, mGluR5-mediated enhancement of NMDA current requires G-protein activation, triggering a signaling cascade including protein kinase C and Src. These results indicate that one neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector. These two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function.",
keywords = "Animals, Enzyme Activation, Enzyme Inhibitors, Excitatory Amino Acid Agonists, Excitatory Amino Acid Antagonists, GTP-Binding Proteins, Guanosine Diphosphate, Hippocampus, In Vitro Techniques, N-Methylaspartate, Patch-Clamp Techniques, Protein Kinase C, Protein-Tyrosine Kinases, Pyramidal Cells, Rats, Rats, Wistar, Receptor, Metabotropic Glutamate 5, Receptors, Metabotropic Glutamate, Receptors, N-Methyl-D-Aspartate, Signal Transduction, Thionucleotides, Up-Regulation, src-Family Kinases",
author = "Pascal Benquet and Gee, {Christine E} and Urs Gerber",
year = "2002",
month = nov,
day = "15",
language = "English",
volume = "22",
pages = "9679--86",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "22",

}

RIS

TY - JOUR

T1 - Two distinct signaling pathways upregulate NMDA receptor responses via two distinct metabotropic glutamate receptor subtypes

AU - Benquet, Pascal

AU - Gee, Christine E

AU - Gerber, Urs

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Molecular processes regulating the gain of NMDA receptors modulate diverse physiological and pathological responses in the CNS. Group I metabotropic glutamate receptors (mGluRs), which neighbor NMDA receptors and which can be coactivated by synaptically released glutamate, couple to several different second messenger pathways, each of which could target NMDA receptors. In CA3 pyramidal cells we show that the activation of mGluR1 potentiates NMDA current via a G-protein-independent mechanism involving Src kinase activation. In contrast, mGluR5-mediated enhancement of NMDA current requires G-protein activation, triggering a signaling cascade including protein kinase C and Src. These results indicate that one neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector. These two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function.

AB - Molecular processes regulating the gain of NMDA receptors modulate diverse physiological and pathological responses in the CNS. Group I metabotropic glutamate receptors (mGluRs), which neighbor NMDA receptors and which can be coactivated by synaptically released glutamate, couple to several different second messenger pathways, each of which could target NMDA receptors. In CA3 pyramidal cells we show that the activation of mGluR1 potentiates NMDA current via a G-protein-independent mechanism involving Src kinase activation. In contrast, mGluR5-mediated enhancement of NMDA current requires G-protein activation, triggering a signaling cascade including protein kinase C and Src. These results indicate that one neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector. These two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function.

KW - Animals

KW - Enzyme Activation

KW - Enzyme Inhibitors

KW - Excitatory Amino Acid Agonists

KW - Excitatory Amino Acid Antagonists

KW - GTP-Binding Proteins

KW - Guanosine Diphosphate

KW - Hippocampus

KW - In Vitro Techniques

KW - N-Methylaspartate

KW - Patch-Clamp Techniques

KW - Protein Kinase C

KW - Protein-Tyrosine Kinases

KW - Pyramidal Cells

KW - Rats

KW - Rats, Wistar

KW - Receptor, Metabotropic Glutamate 5

KW - Receptors, Metabotropic Glutamate

KW - Receptors, N-Methyl-D-Aspartate

KW - Signal Transduction

KW - Thionucleotides

KW - Up-Regulation

KW - src-Family Kinases

M3 - SCORING: Journal article

C2 - 12427823

VL - 22

SP - 9679

EP - 9686

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 22

ER -