Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.

Gabriele Sass; Noula D Shembade; Gisa Tiegs

Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.

Standard

Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling. / Sass, Gabriele; Shembade, Noula D; Tiegs, Gisa.

in: BIOCHEM J, Jahrgang 385, Nr. Pt 2, Pt 2, 2005, S. 537-544.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sass, G, Shembade, ND & Tiegs, G 2005, 'Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.', BIOCHEM J, Jg. 385, Nr. Pt 2, Pt 2, S. 537-544. <http://www.ncbi.nlm.nih.gov/pubmed/15554901?dopt=Citation>

APA

Sass, G., Shembade, N. D., & Tiegs, G. (2005). Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling. BIOCHEM J, 385(Pt 2), 537-544. [Pt 2]. http://www.ncbi.nlm.nih.gov/pubmed/15554901?dopt=Citation

Vancouver

Sass G, Shembade ND, Tiegs G. Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling. BIOCHEM J. 2005;385(Pt 2):537-544. Pt 2.

Bibtex

@article{a5c7889c85bb477ba774bc467e3fe27d,

title = "Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.",

abstract = "TNF (tumour necrosis factor alpha) induces tolerance towards itself in experimental liver injury. Tolerance induction has been shown to be dependent on TNFR1 (TNF receptor 1) signalling, but mechanisms and mediators of TNF-induced hepatic tolerance are unknown. We investigated the TNF-inducible gene-expression profile in livers of TNFR2-/- mice, using cDNA array technology. We found that, out of 793 investigated genes involved in inflammation, cell cycle and signal transduction, 282 were expressed in the mouse liver in response to TNF via TNFR1. Among those, expression of 78 genes was induced, while expression of 60 genes was reduced. We investigated further the cellular expression of the 27 most prominently induced genes, and found that 20 of these genes were up-regulated directly in parenchymal liver cells, representing potentially protective proteins and possible mediators of TNF tolerance. In vitro experiments revealed that overexpression of SOCS1 (silencer of cytokine signalling 1), a member of the SOCS family of proteins, as well as of HO-1 (haem oxygenase-1), but not of SOCS2 or SOCS3, protected isolated primary mouse hepatocytes from TNF-induced apoptosis. The identification of protective genes in hepatocytes is the prerequisite for future development of gene therapies for immune-mediated liver diseases.",

keywords = "Animals, Cells, Cultured, Mice, Mice, Inbred C57BL, Gene Expression Profiling/methods, Gene Expression Regulation/physiology, DNA-Binding Proteins/genetics, Carrier Proteins/genetics, Membrane Proteins, Receptors, Tumor Necrosis Factor, Type I/*metabolism, Apoptosis/physiology, Cytokines/*antagonists & inhibitors/physiology, Galactosamine/pharmacology, Genes/physiology, Heme Oxygenase (Decyclizing)/genetics, Heme Oxygenase-1, Hepatocytes/chemistry/metabolism, Liver/chemistry/drug effects/metabolism, Microarray Analysis/methods, Receptors, Tumor Necrosis Factor, Type II/deficiency/physiology, Repressor Proteins/genetics, Signal Transduction/*physiology, Suppressor of Cytokine Signaling Proteins, Trans-Activators/genetics, Transcription Factors/genetics, Tumor Necrosis Factor-alpha/*metabolism/pharmacology, Animals, Cells, Cultured, Mice, Mice, Inbred C57BL, Gene Expression Profiling/methods, Gene Expression Regulation/physiology, DNA-Binding Proteins/genetics, Carrier Proteins/genetics, Membrane Proteins, Receptors, Tumor Necrosis Factor, Type I/*metabolism, Apoptosis/physiology, Cytokines/*antagonists & inhibitors/physiology, Galactosamine/pharmacology, Genes/physiology, Heme Oxygenase (Decyclizing)/genetics, Heme Oxygenase-1, Hepatocytes/chemistry/metabolism, Liver/chemistry/drug effects/metabolism, Microarray Analysis/methods, Receptors, Tumor Necrosis Factor, Type II/deficiency/physiology, Repressor Proteins/genetics, Signal Transduction/*physiology, Suppressor of Cytokine Signaling Proteins, Trans-Activators/genetics, Transcription Factors/genetics, Tumor Necrosis Factor-alpha/*metabolism/pharmacology",

author = "Gabriele Sass and Shembade, {Noula D} and Gisa Tiegs",

year = "2005",

language = "English",

volume = "385",

pages = "537--544",

journal = "BIOCHEM J",

issn = "0264-6021",

publisher = "PORTLAND PRESS LTD",

number = "Pt 2",

}

RIS

TY - JOUR

T1 - Tumour necrosis factor alpha (TNF)-TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling.

AU - Sass, Gabriele

AU - Shembade, Noula D

AU - Tiegs, Gisa

PY - 2005

Y1 - 2005

N2 - TNF (tumour necrosis factor alpha) induces tolerance towards itself in experimental liver injury. Tolerance induction has been shown to be dependent on TNFR1 (TNF receptor 1) signalling, but mechanisms and mediators of TNF-induced hepatic tolerance are unknown. We investigated the TNF-inducible gene-expression profile in livers of TNFR2-/- mice, using cDNA array technology. We found that, out of 793 investigated genes involved in inflammation, cell cycle and signal transduction, 282 were expressed in the mouse liver in response to TNF via TNFR1. Among those, expression of 78 genes was induced, while expression of 60 genes was reduced. We investigated further the cellular expression of the 27 most prominently induced genes, and found that 20 of these genes were up-regulated directly in parenchymal liver cells, representing potentially protective proteins and possible mediators of TNF tolerance. In vitro experiments revealed that overexpression of SOCS1 (silencer of cytokine signalling 1), a member of the SOCS family of proteins, as well as of HO-1 (haem oxygenase-1), but not of SOCS2 or SOCS3, protected isolated primary mouse hepatocytes from TNF-induced apoptosis. The identification of protective genes in hepatocytes is the prerequisite for future development of gene therapies for immune-mediated liver diseases.

AB - TNF (tumour necrosis factor alpha) induces tolerance towards itself in experimental liver injury. Tolerance induction has been shown to be dependent on TNFR1 (TNF receptor 1) signalling, but mechanisms and mediators of TNF-induced hepatic tolerance are unknown. We investigated the TNF-inducible gene-expression profile in livers of TNFR2-/- mice, using cDNA array technology. We found that, out of 793 investigated genes involved in inflammation, cell cycle and signal transduction, 282 were expressed in the mouse liver in response to TNF via TNFR1. Among those, expression of 78 genes was induced, while expression of 60 genes was reduced. We investigated further the cellular expression of the 27 most prominently induced genes, and found that 20 of these genes were up-regulated directly in parenchymal liver cells, representing potentially protective proteins and possible mediators of TNF tolerance. In vitro experiments revealed that overexpression of SOCS1 (silencer of cytokine signalling 1), a member of the SOCS family of proteins, as well as of HO-1 (haem oxygenase-1), but not of SOCS2 or SOCS3, protected isolated primary mouse hepatocytes from TNF-induced apoptosis. The identification of protective genes in hepatocytes is the prerequisite for future development of gene therapies for immune-mediated liver diseases.

KW - Animals

KW - Cells, Cultured

KW - Mice

KW - Mice, Inbred C57BL

KW - Gene Expression Profiling/methods

KW - Gene Expression Regulation/physiology

KW - DNA-Binding Proteins/genetics

KW - Carrier Proteins/genetics

KW - Membrane Proteins

KW - Receptors, Tumor Necrosis Factor, Type I/metabolism

KW - Apoptosis/physiology

KW - Cytokines/antagonists & inhibitors/physiology

KW - Galactosamine/pharmacology

KW - Genes/physiology

KW - Heme Oxygenase (Decyclizing)/genetics

KW - Heme Oxygenase-1

KW - Hepatocytes/chemistry/metabolism

KW - Liver/chemistry/drug effects/metabolism

KW - Microarray Analysis/methods

KW - Receptors, Tumor Necrosis Factor, Type II/deficiency/physiology

KW - Repressor Proteins/genetics

KW - Signal Transduction/physiology

KW - Suppressor of Cytokine Signaling Proteins

KW - Trans-Activators/genetics

KW - Transcription Factors/genetics

KW - Tumor Necrosis Factor-alpha/metabolism/pharmacology