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Tumour budding with and without admixed inflammation: two different sides of the same coin?

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Tumour budding with and without admixed inflammation: two different sides of the same coin? / Max, Nicole; Harbaum, Lars; Pollheimer, Marion J; Lindtner, Richard A; Kornprat, Peter; Langner, Cord.

in: BRIT J CANCER, Jahrgang 114, Nr. 4, 16.02.2016, S. 368-71.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Max, N, Harbaum, L, Pollheimer, MJ, Lindtner, RA, Kornprat, P & Langner, C 2016, 'Tumour budding with and without admixed inflammation: two different sides of the same coin?', BRIT J CANCER, Jg. 114, Nr. 4, S. 368-71. https://doi.org/10.1038/bjc.2015.454

APA

Max, N., Harbaum, L., Pollheimer, M. J., Lindtner, R. A., Kornprat, P., & Langner, C. (2016). Tumour budding with and without admixed inflammation: two different sides of the same coin? BRIT J CANCER, 114(4), 368-71. https://doi.org/10.1038/bjc.2015.454

Vancouver

Max N, Harbaum L, Pollheimer MJ, Lindtner RA, Kornprat P, Langner C. Tumour budding with and without admixed inflammation: two different sides of the same coin? BRIT J CANCER. 2016 Feb 16;114(4):368-71. https://doi.org/10.1038/bjc.2015.454

Bibtex

@article{eb3db9a29b0540579de528b01f8d52fc,
title = "Tumour budding with and without admixed inflammation: two different sides of the same coin?",
abstract = "BACKGROUND: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets.METHODS: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses.RESULTS: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect.CONCLUSIONS: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.",
keywords = "Aged, Cohort Studies, Colorectal Neoplasms, Female, Humans, Inflammation, Male, Neoplasm Invasiveness, Prognosis, Journal Article",
author = "Nicole Max and Lars Harbaum and Pollheimer, {Marion J} and Lindtner, {Richard A} and Peter Kornprat and Cord Langner",
year = "2016",
month = feb,
day = "16",
doi = "10.1038/bjc.2015.454",
language = "English",
volume = "114",
pages = "368--71",
journal = "BRIT J CANCER",
issn = "0007-0920",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Tumour budding with and without admixed inflammation: two different sides of the same coin?

AU - Max, Nicole

AU - Harbaum, Lars

AU - Pollheimer, Marion J

AU - Lindtner, Richard A

AU - Kornprat, Peter

AU - Langner, Cord

PY - 2016/2/16

Y1 - 2016/2/16

N2 - BACKGROUND: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets.METHODS: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses.RESULTS: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect.CONCLUSIONS: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.

AB - BACKGROUND: Tumour budding is an adverse prognostic indicator in colorectal cancer (CRC). Marked overall peritumoural inflammation has been associated with favourable outcome and may lead to the presence of isolated cancer cells due to destruction of invading cancer cell islets.METHODS: We assessed the prognostic significance of tumour budding and peritumoural inflammation in a cohort of 381 patients with CRC applying univariate and multivariate analyses.RESULTS: Patients with high-grade budding and marked inflammation had a significantly better outcome compared with patients with high-grade budding and only mild inflammation. Outcome in these cases, however, was still worse compared with cases with low-grade budding, in which the extent of peritumoural inflammation had no further prognostic effect.CONCLUSIONS: Tumour budding proved to be a powerful prognostic variable in patients with CRC. Scattering of invading cancer cell islets by marked overall peritumoural inflammation seems to have a minor role.

KW - Aged

KW - Cohort Studies

KW - Colorectal Neoplasms

KW - Female

KW - Humans

KW - Inflammation

KW - Male

KW - Neoplasm Invasiveness

KW - Prognosis

KW - Journal Article

U2 - 10.1038/bjc.2015.454

DO - 10.1038/bjc.2015.454

M3 - SCORING: Journal article

C2 - 26766735

VL - 114

SP - 368

EP - 371

JO - BRIT J CANCER

JF - BRIT J CANCER

SN - 0007-0920

IS - 4

ER -