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Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis

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Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. / Ell, Brian; Mercatali, Laura; Ibrahim, Toni; Campbell, Neil; Schwarzenbach, Heidi; Pantel, Klaus; Amadori, Dino; Kang, Yibin.

in: CANCER CELL, Jahrgang 24, Nr. 4, 14.10.2013, S. 542-56.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ell, B, Mercatali, L, Ibrahim, T, Campbell, N, Schwarzenbach, H, Pantel, K, Amadori, D & Kang, Y 2013, 'Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis', CANCER CELL, Jg. 24, Nr. 4, S. 542-56. https://doi.org/10.1016/j.ccr.2013.09.008

APA

Ell, B., Mercatali, L., Ibrahim, T., Campbell, N., Schwarzenbach, H., Pantel, K., Amadori, D., & Kang, Y. (2013). Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. CANCER CELL, 24(4), 542-56. https://doi.org/10.1016/j.ccr.2013.09.008

Vancouver

Ell B, Mercatali L, Ibrahim T, Campbell N, Schwarzenbach H, Pantel K et al. Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. CANCER CELL. 2013 Okt 14;24(4):542-56. https://doi.org/10.1016/j.ccr.2013.09.008

Bibtex

@article{0d33039020364eb584c88d853d6d8737,
title = "Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis",
abstract = "Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFκB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.",
keywords = "Animals, Antigens, CD18, Bone Neoplasms, Bone Resorption, Cell Line, Tumor, Culture Media, Conditioned, Humans, Intercellular Adhesion Molecule-1, Mice, MicroRNAs, NF-kappa B, Neoplasm Metastasis, Osteoclasts, Osteolysis, Tumor Markers, Biological",
author = "Brian Ell and Laura Mercatali and Toni Ibrahim and Neil Campbell and Heidi Schwarzenbach and Klaus Pantel and Dino Amadori and Yibin Kang",
note = "Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",
year = "2013",
month = oct,
day = "14",
doi = "10.1016/j.ccr.2013.09.008",
language = "English",
volume = "24",
pages = "542--56",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis

AU - Ell, Brian

AU - Mercatali, Laura

AU - Ibrahim, Toni

AU - Campbell, Neil

AU - Schwarzenbach, Heidi

AU - Pantel, Klaus

AU - Amadori, Dino

AU - Kang, Yibin

N1 - Copyright © 2013 Elsevier Inc. All rights reserved.

PY - 2013/10/14

Y1 - 2013/10/14

N2 - Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFκB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.

AB - Understanding the mechanism by which tumor cells influence osteoclast differentiation is crucial for improving treatment of osteolytic metastasis. Here, we report broad microRNA (miRNA) expression changes in differentiating osteoclasts after exposure to tumor-conditioned media, in part through activation of NFκB signaling by soluble intracellular adhesion molecule (sICAM1) secreted from bone-metastatic cancer cells. Ectopic expression of multiple miRNAs downregulated during osteoclastogenesis suppresses osteoclast differentiation by targeting important osteoclast genes. Intravenous delivery of these miRNAs in vivo inhibits osteoclast activity and reduces osteolytic bone metastasis. Importantly, serum levels of sICAM1 and two osteoclast miRNAs, miR-16 and miR-378, which are elevated in osteoclast differentiation, correlate with bone metastasis burden. These findings establish miRNAs as potential therapeutic targets and clinical biomarkers of bone metastasis.

KW - Animals

KW - Antigens, CD18

KW - Bone Neoplasms

KW - Bone Resorption

KW - Cell Line, Tumor

KW - Culture Media, Conditioned

KW - Humans

KW - Intercellular Adhesion Molecule-1

KW - Mice

KW - MicroRNAs

KW - NF-kappa B

KW - Neoplasm Metastasis

KW - Osteoclasts

KW - Osteolysis

KW - Tumor Markers, Biological

U2 - 10.1016/j.ccr.2013.09.008

DO - 10.1016/j.ccr.2013.09.008

M3 - SCORING: Journal article

C2 - 24135284

VL - 24

SP - 542

EP - 556

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 4

ER -