Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.
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Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system. / Wegwitz, Florian; Kluth, Mark-Andreas; Mänz, Claudia; Otto, Benjamin; Gruner, Katharina; Heinlein, Christina; Kühl, Marion; Warnecke, Gabriele; Schumacher, Udo; Deppert, Wolfgang; Tolstonog, Genrich V.
in: PLOS ONE, Jahrgang 5, Nr. 8, 8, 2010, S. 12103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tumorigenic WAP-T mouse mammary carcinoma cells: a model for a self-reproducing homeostatic cancer cell system.
AU - Wegwitz, Florian
AU - Kluth, Mark-Andreas
AU - Mänz, Claudia
AU - Otto, Benjamin
AU - Gruner, Katharina
AU - Heinlein, Christina
AU - Kühl, Marion
AU - Warnecke, Gabriele
AU - Schumacher, Udo
AU - Deppert, Wolfgang
AU - Tolstonog, Genrich V
PY - 2010
Y1 - 2010
N2 - In analogy to normal stem cell differentiation, the current cancer stem cell (CSC) model presumes a hierarchical organization and an irreversible differentiation in tumor tissue. Accordingly, CSCs should comprise only a small subset of the tumor cells, which feeds tumor growth. However, some recent findings raised doubts on the general applicability of the CSC model and asked for its refinement.
AB - In analogy to normal stem cell differentiation, the current cancer stem cell (CSC) model presumes a hierarchical organization and an irreversible differentiation in tumor tissue. Accordingly, CSCs should comprise only a small subset of the tumor cells, which feeds tumor growth. However, some recent findings raised doubts on the general applicability of the CSC model and asked for its refinement.
U2 - 10.1371/journal.pone.0012103
DO - 10.1371/journal.pone.0012103
M3 - SCORING: Zeitschriftenaufsatz
VL - 5
SP - 12103
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 8
M1 - 8
ER -
