Tumor size is a determinant of the rate of stage T1 renal cell cancer synchronous metastasis.
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Tumor size is a determinant of the rate of stage T1 renal cell cancer synchronous metastasis. / Lughezzani, Giovanni; Jeldres, Claudio; Isbarn, Hendrik; Perrotte, Paul; Shariat, Shahrokh F; Sun, Maxine; Widmer, Hugues; Arjane, Philippe; Peloquin, Francois; Pharand, Daniel; Patard, Jean-Jacques; Graefen, Markus; Montorsi, Francesco; Karakiewicz, Pierre I.
in: J UROLOGY, Jahrgang 182, Nr. 4, 4, 2009, S. 1287-1293.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tumor size is a determinant of the rate of stage T1 renal cell cancer synchronous metastasis.
AU - Lughezzani, Giovanni
AU - Jeldres, Claudio
AU - Isbarn, Hendrik
AU - Perrotte, Paul
AU - Shariat, Shahrokh F
AU - Sun, Maxine
AU - Widmer, Hugues
AU - Arjane, Philippe
AU - Peloquin, Francois
AU - Pharand, Daniel
AU - Patard, Jean-Jacques
AU - Graefen, Markus
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I
PY - 2009
Y1 - 2009
N2 - PURPOSE: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. MATERIALS AND METHODS: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. RESULTS: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p
AB - PURPOSE: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. MATERIALS AND METHODS: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. RESULTS: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p
M3 - SCORING: Zeitschriftenaufsatz
VL - 182
SP - 1287
EP - 1293
JO - J UROLOGY
JF - J UROLOGY
SN - 0022-5347
IS - 4
M1 - 4
ER -