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Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure

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Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure. / Ratovitski, Edward A.; Honecker, Friedemann; Dyshlovoy, Sergey A.

in: MAR DRUGS, Jahrgang 14, Nr. 8, 154, 08.2016.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ratovitski, EA, Honecker, F & Dyshlovoy, SA 2016, 'Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure', MAR DRUGS, Jg. 14, Nr. 8, 154. https://doi.org/10.3390/md14080154

APA

Ratovitski, E. A., Honecker, F., & Dyshlovoy, S. A. (2016). Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure. MAR DRUGS, 14(8), [154]. https://doi.org/10.3390/md14080154

Vancouver

Ratovitski EA, Honecker F, Dyshlovoy SA. Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure. MAR DRUGS. 2016 Aug;14(8). 154. https://doi.org/10.3390/md14080154

Bibtex

@article{2cd04d9b2fd64102bb24998500a5d73c,
title = "Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure",
abstract = "Targeting autophagic pathways might play a critical role in designing novel chemotherapeutic approaches in the treatment of human cancers, and the prevention of tumor-derived chemoresistance. Marine compounds were found to decrease tumor cell growth in vitro and in vivo. Some of them were shown to induce autophagic flux in tumor cells. In this study, we observed that the selected marine life-derived compounds (Chromomycin A2, Psammaplin A, and Ilimaquinone) induce expression of several autophagic signaling intermediates in human squamous cell carcinoma, glioblastoma, and colorectal carcinoma cells in vitro through a transcriptional regulation by tumor protein (TP)-p53 family members. These conclusions were supported by specific qPCR expression analysis, luciferase reporter promoter assay, and chromatin immunoprecipitation of promoter sequences bound to the TP53 family proteins, and silencing of the TP53 members in tumor cells.",
keywords = "Autophagy, Cancer, Marine drugs, P53 family members, Transcription",
author = "Ratovitski, {Edward A.} and Friedemann Honecker and Dyshlovoy, {Sergey A.}",
note = "Publisher Copyright: {\textcopyright} 2016 by the author; licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2016",
month = aug,
doi = "10.3390/md14080154",
language = "English",
volume = "14",
journal = "MAR DRUGS",
issn = "1660-3397",
publisher = "MDPI AG",
number = "8",

}

RIS

TY - JOUR

T1 - Tumor Protein (TP)-p53 members as regulators of autophagy in tumor cells upon marine drug exposure

AU - Ratovitski, Edward A.

AU - Honecker, Friedemann

AU - Dyshlovoy, Sergey A.

N1 - Publisher Copyright: © 2016 by the author; licensee MDPI, Basel, Switzerland. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2016/8

Y1 - 2016/8

N2 - Targeting autophagic pathways might play a critical role in designing novel chemotherapeutic approaches in the treatment of human cancers, and the prevention of tumor-derived chemoresistance. Marine compounds were found to decrease tumor cell growth in vitro and in vivo. Some of them were shown to induce autophagic flux in tumor cells. In this study, we observed that the selected marine life-derived compounds (Chromomycin A2, Psammaplin A, and Ilimaquinone) induce expression of several autophagic signaling intermediates in human squamous cell carcinoma, glioblastoma, and colorectal carcinoma cells in vitro through a transcriptional regulation by tumor protein (TP)-p53 family members. These conclusions were supported by specific qPCR expression analysis, luciferase reporter promoter assay, and chromatin immunoprecipitation of promoter sequences bound to the TP53 family proteins, and silencing of the TP53 members in tumor cells.

AB - Targeting autophagic pathways might play a critical role in designing novel chemotherapeutic approaches in the treatment of human cancers, and the prevention of tumor-derived chemoresistance. Marine compounds were found to decrease tumor cell growth in vitro and in vivo. Some of them were shown to induce autophagic flux in tumor cells. In this study, we observed that the selected marine life-derived compounds (Chromomycin A2, Psammaplin A, and Ilimaquinone) induce expression of several autophagic signaling intermediates in human squamous cell carcinoma, glioblastoma, and colorectal carcinoma cells in vitro through a transcriptional regulation by tumor protein (TP)-p53 family members. These conclusions were supported by specific qPCR expression analysis, luciferase reporter promoter assay, and chromatin immunoprecipitation of promoter sequences bound to the TP53 family proteins, and silencing of the TP53 members in tumor cells.

KW - Autophagy

KW - Cancer

KW - Marine drugs

KW - P53 family members

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=84984992239&partnerID=8YFLogxK

U2 - 10.3390/md14080154

DO - 10.3390/md14080154

M3 - SCORING: Journal article

C2 - 27537898

AN - SCOPUS:84984992239

VL - 14

JO - MAR DRUGS

JF - MAR DRUGS

SN - 1660-3397

IS - 8

M1 - 154

ER -