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Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study

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Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study. / Rodríguez-Molino, Paula; Tebruegge, Marc; Noguera-Julian, Antoni; Neth, Olaf; Fidler, Katy; Brinkmann, Folke; Sainz, Talia; Ivaskeviciene, Inga; Ritz, Nicole; Brito, Maria Joao; Milheiro Silva, Tiago; Chechenieva, Vira; Serdiuk, Maryna; Lancella, Laura; Russo, Cristina; Soler-García, Aleix; Navarro, Maria Luisa; Krueger, Renate; Feiterna-Sperling, Cornelia; Starshinova, Anna; Hiteva, Antonina; Hoffmann, Anna; Kalibatas, Paulius; Lo Vecchio, Andrea; Scarano, Sara Maria; Bustillo, Matilde; Blázquez Gamero, Daniel; Espiau, María; Buonsenso, Danilo; Falcón, Lola; Turnbull, Louise; Colino, Elena; Rueda, Santiago; Buxbaum, Charlotte; Carazo, Begoña; Alvarez, Cristina; Dapena, Marta; Piqueras, Anabel; Velizarova, Svetlana; Ozere, Iveta; Götzinger, Florian; Pareja, Marta; Garrote Llanos, Maria Isabel; Soto, Beatriz; Rodríguez Martín, Sonia; Korta, Jose Javier; Pérez-Gorricho, Beatriz; Herranz, Mercedes; Hernández-Bartolomé, Ángel; Díaz-Almirón, Mariana; Kohns Vasconcelos, Malte; Ferreras-Antolín, Laura; Santiago-García, Begoña.

in: CLIN INFECT DIS, Jahrgang 79, Nr. 1, 19.07.2024, S. 215-222.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rodríguez-Molino, P, Tebruegge, M, Noguera-Julian, A, Neth, O, Fidler, K, Brinkmann, F, Sainz, T, Ivaskeviciene, I, Ritz, N, Brito, MJ, Milheiro Silva, T, Chechenieva, V, Serdiuk, M, Lancella, L, Russo, C, Soler-García, A, Navarro, ML, Krueger, R, Feiterna-Sperling, C, Starshinova, A, Hiteva, A, Hoffmann, A, Kalibatas, P, Lo Vecchio, A, Scarano, SM, Bustillo, M, Blázquez Gamero, D, Espiau, M, Buonsenso, D, Falcón, L, Turnbull, L, Colino, E, Rueda, S, Buxbaum, C, Carazo, B, Alvarez, C, Dapena, M, Piqueras, A, Velizarova, S, Ozere, I, Götzinger, F, Pareja, M, Garrote Llanos, MI, Soto, B, Rodríguez Martín, S, Korta, JJ, Pérez-Gorricho, B, Herranz, M, Hernández-Bartolomé, Á, Díaz-Almirón, M, Kohns Vasconcelos, M, Ferreras-Antolín, L & Santiago-García, B 2024, 'Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study', CLIN INFECT DIS, Jg. 79, Nr. 1, S. 215-222. https://doi.org/10.1093/cid/ciae158

APA

Rodríguez-Molino, P., Tebruegge, M., Noguera-Julian, A., Neth, O., Fidler, K., Brinkmann, F., Sainz, T., Ivaskeviciene, I., Ritz, N., Brito, M. J., Milheiro Silva, T., Chechenieva, V., Serdiuk, M., Lancella, L., Russo, C., Soler-García, A., Navarro, M. L., Krueger, R., Feiterna-Sperling, C., ... Santiago-García, B. (2024). Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study. CLIN INFECT DIS, 79(1), 215-222. https://doi.org/10.1093/cid/ciae158

Vancouver

Rodríguez-Molino P, Tebruegge M, Noguera-Julian A, Neth O, Fidler K, Brinkmann F et al. Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study. CLIN INFECT DIS. 2024 Jul 19;79(1):215-222. https://doi.org/10.1093/cid/ciae158

Bibtex

@article{f5d2f001648649aca34efbb579384288,
title = "Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study",
abstract = "BACKGROUND: In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe.METHODS: Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000-2020.RESULTS: A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P = .013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P < .001; odds ratio [95% confidence interval], 2.073 [1.37-3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P < .001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P < .001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P = .083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P = .004).CONCLUSIONS: Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies.",
keywords = "Adolescent, Antitubercular Agents/therapeutic use, Case-Control Studies, Child, Child, Preschool, Europe/epidemiology, Female, Humans, Immunocompromised Host, Infant, Male, Tuberculin Test, Tuberculosis/epidemiology",
author = "Paula Rodr{\'i}guez-Molino and Marc Tebruegge and Antoni Noguera-Julian and Olaf Neth and Katy Fidler and Folke Brinkmann and Talia Sainz and Inga Ivaskeviciene and Nicole Ritz and Brito, {Maria Joao} and {Milheiro Silva}, Tiago and Vira Chechenieva and Maryna Serdiuk and Laura Lancella and Cristina Russo and Aleix Soler-Garc{\'i}a and Navarro, {Maria Luisa} and Renate Krueger and Cornelia Feiterna-Sperling and Anna Starshinova and Antonina Hiteva and Anna Hoffmann and Paulius Kalibatas and {Lo Vecchio}, Andrea and Scarano, {Sara Maria} and Matilde Bustillo and {Bl{\'a}zquez Gamero}, Daniel and Mar{\'i}a Espiau and Danilo Buonsenso and Lola Falc{\'o}n and Louise Turnbull and Elena Colino and Santiago Rueda and Charlotte Buxbaum and Bego{\~n}a Carazo and Cristina Alvarez and Marta Dapena and Anabel Piqueras and Svetlana Velizarova and Iveta Ozere and Florian G{\"o}tzinger and Marta Pareja and {Garrote Llanos}, {Maria Isabel} and Beatriz Soto and {Rodr{\'i}guez Mart{\'i}n}, Sonia and Korta, {Jose Javier} and Beatriz P{\'e}rez-Gorricho and Mercedes Herranz and {\'A}ngel Hern{\'a}ndez-Bartolom{\'e} and Mariana D{\'i}az-Almir{\'o}n and {Kohns Vasconcelos}, Malte and Laura Ferreras-Antol{\'i}n and Bego{\~n}a Santiago-Garc{\'i}a",
note = "{\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.",
year = "2024",
month = jul,
day = "19",
doi = "10.1093/cid/ciae158",
language = "English",
volume = "79",
pages = "215--222",
journal = "CLIN INFECT DIS",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Tuberculosis disease in immunocompromised children and adolescents: a pTBnet multi-centre case-control study

AU - Rodríguez-Molino, Paula

AU - Tebruegge, Marc

AU - Noguera-Julian, Antoni

AU - Neth, Olaf

AU - Fidler, Katy

AU - Brinkmann, Folke

AU - Sainz, Talia

AU - Ivaskeviciene, Inga

AU - Ritz, Nicole

AU - Brito, Maria Joao

AU - Milheiro Silva, Tiago

AU - Chechenieva, Vira

AU - Serdiuk, Maryna

AU - Lancella, Laura

AU - Russo, Cristina

AU - Soler-García, Aleix

AU - Navarro, Maria Luisa

AU - Krueger, Renate

AU - Feiterna-Sperling, Cornelia

AU - Starshinova, Anna

AU - Hiteva, Antonina

AU - Hoffmann, Anna

AU - Kalibatas, Paulius

AU - Lo Vecchio, Andrea

AU - Scarano, Sara Maria

AU - Bustillo, Matilde

AU - Blázquez Gamero, Daniel

AU - Espiau, María

AU - Buonsenso, Danilo

AU - Falcón, Lola

AU - Turnbull, Louise

AU - Colino, Elena

AU - Rueda, Santiago

AU - Buxbaum, Charlotte

AU - Carazo, Begoña

AU - Alvarez, Cristina

AU - Dapena, Marta

AU - Piqueras, Anabel

AU - Velizarova, Svetlana

AU - Ozere, Iveta

AU - Götzinger, Florian

AU - Pareja, Marta

AU - Garrote Llanos, Maria Isabel

AU - Soto, Beatriz

AU - Rodríguez Martín, Sonia

AU - Korta, Jose Javier

AU - Pérez-Gorricho, Beatriz

AU - Herranz, Mercedes

AU - Hernández-Bartolomé, Ángel

AU - Díaz-Almirón, Mariana

AU - Kohns Vasconcelos, Malte

AU - Ferreras-Antolín, Laura

AU - Santiago-García, Begoña

N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

PY - 2024/7/19

Y1 - 2024/7/19

N2 - BACKGROUND: In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe.METHODS: Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000-2020.RESULTS: A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P = .013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P < .001; odds ratio [95% confidence interval], 2.073 [1.37-3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P < .001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P < .001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P = .083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P = .004).CONCLUSIONS: Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies.

AB - BACKGROUND: In high-resource settings, the survival of children with immunocompromise (IC) has increased and immunosuppressive therapies are increasingly being used. This study aimed to determine the clinical characteristics, performance of diagnostic tools, and outcome of IC children with tuberculosis (TB) in Europe.METHODS: Multicenter, matched case-control study within the Pediatric Tuberculosis Network European Trials Group, capturing TB cases <18 years diagnosed 2000-2020.RESULTS: A total of 417 TB cases were included, comprising 139 children who are IC (human immunodeficiency virus, inborn errors of immunity, drug-induced immunosuppression, and other immunocompromising conditions) and 278 non-IC children as controls. Nonrespiratory TB was more frequent among cases than controls (32.4% vs 21.2%; P = .013). Patients with IC had an increased likelihood of presenting with severe disease (57.6% vs 38.5%; P < .001; odds ratio [95% confidence interval], 2.073 [1.37-3.13]). Children with IC had higher rates of false-negative tuberculin skin test (31.9% vs 6.0%; P < .001) and QuantiFERON-TB Gold assay (30.0% vs 7.3%; P < .001) results at diagnosis. Overall, the microbiological confirmation rate was similar in IC and non-IC cases (58.3% vs 49.3%; P = .083). Although the mortality in children with IC was <1%, the rate of long-term sequelae was significantly higher than in non-IC cases (14.8% vs 6.1%; P = .004).CONCLUSIONS: Children with IC and TB in Europe have increased rates of nonrespiratory TB, severe disease, and long-term sequelae. Immune-based TB tests have poor sensitivity in those children. Future research should focus on developing improved immunological TB tests that perform better in patients with IC, and determining the reasons for the increased risk of long-term sequelae, with the aim to design preventive management strategies.

KW - Adolescent

KW - Antitubercular Agents/therapeutic use

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Europe/epidemiology

KW - Female

KW - Humans

KW - Immunocompromised Host

KW - Infant

KW - Male

KW - Tuberculin Test

KW - Tuberculosis/epidemiology

U2 - 10.1093/cid/ciae158

DO - 10.1093/cid/ciae158

M3 - SCORING: Journal article

C2 - 38568992

VL - 79

SP - 215

EP - 222

JO - CLIN INFECT DIS

JF - CLIN INFECT DIS

SN - 1058-4838

IS - 1

ER -