Trends in the epidemiology of Clostridioides difficile infection in Germany
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Trends in the epidemiology of Clostridioides difficile infection in Germany. / Vehreschild, Maria Johanna Gobertina Tetuanui; Schreiber, Stefan; von Müller, Lutz; Epple, Hans-Jörg; Weinke, Thomas; Manthey, Carolin; Oh, Jun; Wahler, Steffen; Stallmach, Andreas.
in: INFECTION, Jahrgang 51, Nr. 6, 12.2023, S. 1695-1702.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Trends in the epidemiology of Clostridioides difficile infection in Germany
AU - Vehreschild, Maria Johanna Gobertina Tetuanui
AU - Schreiber, Stefan
AU - von Müller, Lutz
AU - Epple, Hans-Jörg
AU - Weinke, Thomas
AU - Manthey, Carolin
AU - Oh, Jun
AU - Wahler, Steffen
AU - Stallmach, Andreas
N1 - © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
PY - 2023/12
Y1 - 2023/12
N2 - PURPOSES: Despite reports of a declining incidence over the last decade, Clostridioides difficile infection (CDI) is still considered the most important healthcare-associated causes of diarrhea worldwide. In Germany, several measures have been taken to observe, report, and influence this development. This report aims to analyze the development of hospital coding for CDI in Germany over the last decade and to use it to estimate the public health burden caused by CDI.METHODS: Reports from the Institute for Hospital Remuneration Systems, German Federal Statistical Office (DESTATIS), the Robert-Koch-Institute (RKI), Saxonian authorities and hospital quality reports during 2010-2021 were examined for CDI coding and assessed in a structured expert consultation. Analysis was performed using 2019 versions of Microsoft Excel® and Microsoft Access®.RESULTS: Peaks of 32,203 cases with a primary diagnosis (PD) of CDI and 78,648 cases with a secondary diagnosis (SD) of CDI were observed in 2015. The number of cases had decreased to 15,412 PD cases (- 52.1%) and 40,188 SD cases (- 48.9%) by 2021. These results were paralleled by a similar decline in notifiable severe cases. However, average duration of hospitalization of the cases remained constant during this period.CONCLUSIONS: Hospital coding of CDI and notification to authorities has approximately halved from 2015 to 2021. Potential influential factors include hospital hygiene campaigns, implementation of antibiotic stewardship programs, social distancing due to the COVID-19 pandemic, and a decrease in more pathogenic subtypes of bacteria. Further research is necessary to validate the multiple possible drivers for this development.
AB - PURPOSES: Despite reports of a declining incidence over the last decade, Clostridioides difficile infection (CDI) is still considered the most important healthcare-associated causes of diarrhea worldwide. In Germany, several measures have been taken to observe, report, and influence this development. This report aims to analyze the development of hospital coding for CDI in Germany over the last decade and to use it to estimate the public health burden caused by CDI.METHODS: Reports from the Institute for Hospital Remuneration Systems, German Federal Statistical Office (DESTATIS), the Robert-Koch-Institute (RKI), Saxonian authorities and hospital quality reports during 2010-2021 were examined for CDI coding and assessed in a structured expert consultation. Analysis was performed using 2019 versions of Microsoft Excel® and Microsoft Access®.RESULTS: Peaks of 32,203 cases with a primary diagnosis (PD) of CDI and 78,648 cases with a secondary diagnosis (SD) of CDI were observed in 2015. The number of cases had decreased to 15,412 PD cases (- 52.1%) and 40,188 SD cases (- 48.9%) by 2021. These results were paralleled by a similar decline in notifiable severe cases. However, average duration of hospitalization of the cases remained constant during this period.CONCLUSIONS: Hospital coding of CDI and notification to authorities has approximately halved from 2015 to 2021. Potential influential factors include hospital hygiene campaigns, implementation of antibiotic stewardship programs, social distancing due to the COVID-19 pandemic, and a decrease in more pathogenic subtypes of bacteria. Further research is necessary to validate the multiple possible drivers for this development.
U2 - 10.1007/s15010-023-02044-5
DO - 10.1007/s15010-023-02044-5
M3 - SCORING: Journal article
C2 - 37162717
VL - 51
SP - 1695
EP - 1702
JO - INFECTION
JF - INFECTION
SN - 0300-8126
IS - 6
ER -