Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
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Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study. / de Man Lapidoth, Julia; Hultdin, Johan; Jonsson, P Andreas; Eriksson Svensson, Maria; Wennberg, Maria; Zeller, Tanja; Söderberg, Stefan.
in: BMJ OPEN, Jahrgang 13, Nr. 8, 30.08.2023, S. e072664.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Trends in renal function in Northern Sweden 1986-2014: data from the seven cross-sectional surveys within the Northern Sweden MONICA study
AU - de Man Lapidoth, Julia
AU - Hultdin, Johan
AU - Jonsson, P Andreas
AU - Eriksson Svensson, Maria
AU - Wennberg, Maria
AU - Zeller, Tanja
AU - Söderberg, Stefan
N1 - © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023/8/30
Y1 - 2023/8/30
N2 - OBJECTIVE: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.DESIGN: Repeated cross-sectional population-based studies.SETTING: The two Northern counties (Norr- and Västerbotten) in Sweden.PARTICIPANTS: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).INTERVENTIONS: None.MEASURES: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFRcrea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFRcysC). Renal function over time was analysed using univariable and multivariable linear regression models.RESULTS: Renal function, both eGFRcrea and eGFRcysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFRcrea and eGFRcysC (both p<0.001) after adjustment for classical cardiovascular RF.CONCLUSION: Renal function has deteriorated in Northern Sweden between 1986 and 2014.
AB - OBJECTIVE: The prevalence of chronic kidney disease (CKD) is increasing globally, and CKD is closely related to cardiovascular disease (CVD). CKD and CVD share several risk factors (RF), such as diabetes, hypertension, obesity and smoking, and the prevalence of these RF has changed during the last decades, and we aimed to study the effect on renal function over time.DESIGN: Repeated cross-sectional population-based studies.SETTING: The two Northern counties (Norr- and Västerbotten) in Sweden.PARTICIPANTS: Within the MONitoring Trends and Determinants of CArdiovascular Disease (MONICA) study, seven surveys were performed between 1986 and 2014, including participants aged 25-64 years (n=10 185).INTERVENTIONS: None.MEASURES: Information on anthropometry, blood pressure and cardiovascular risk factors was collected. Creatinine and cystatin C were analysed in stored blood samples and the estimated glomerular filtration rate (eGFR) calculated using the creatinine-based Lund-Malmö revised and Chronic Kidney Disease Epidemiology Collaboration (eGFRcrea) equations as well as the cystatin C-based Caucasian, Asian, Paediatric and Adult cohort (CAPA) equation (eGFRcysC). Renal function over time was analysed using univariable and multivariable linear regression models.RESULTS: Renal function, both eGFRcrea and eGFRcysC, decreased over time (both p<0.001) and differed between counties and sexes. In a multivariable analysis, study year remained inversely associated with both eGFRcrea and eGFRcysC (both p<0.001) after adjustment for classical cardiovascular RF.CONCLUSION: Renal function has deteriorated in Northern Sweden between 1986 and 2014.
KW - Adult
KW - Humans
KW - Child
KW - Cross-Sectional Studies
KW - Cystatin C
KW - Cardiovascular Diseases/epidemiology
KW - Creatinine
KW - Sweden/epidemiology
KW - Renal Insufficiency, Chronic/epidemiology
KW - Kidney/physiology
U2 - 10.1136/bmjopen-2023-072664
DO - 10.1136/bmjopen-2023-072664
M3 - SCORING: Journal article
C2 - 37648389
VL - 13
SP - e072664
JO - BMJ OPEN
JF - BMJ OPEN
SN - 2044-6055
IS - 8
ER -