TREM2 rare variant p.R47H is not associated with Parkinson's disease

David Mengel; Mathias Thelen; Monika Balzer-Geldsetzer; Charlotte Söling; Jan-Philipp Bach; Eva Schaeffer; Christine Herold; Tim Becker; Inga Liepelt; Julian Becker; Steffi Riedel-Heller; Martin Scherer; Frank Jessen; Wolfgang Maier; Richard Dodel; Alfredo Ramirez

doi:10.1016/j.parkreldis.2015.11.026

TREM2 rare variant p.R47H is not associated with Parkinson's disease

David Mengel
Mathias Thelen
Monika Balzer-Geldsetzer
Charlotte Söling
Jan-Philipp Bach
Eva Schaeffer
Christine Herold
Tim Becker
Inga Liepelt
Julian Becker
Steffi Riedel-Heller
Martin Scherer
Frank Jessen
Wolfgang Maier
Richard Dodel
Alfredo Ramirez

Beteiligte Einrichtungen

Institut und Poliklinik für Allgemeinmedizin

Abstract

Variant p.R47H of triggering receptor expressed on myeloid cells 2 (TREM2) has been associated with Parkinson's disease (PD). We screened this TREM2-variant in 821 PD patients including 261 demented PD patients (PDD) and in healthy controls (n = 919). Neither the entire PD nor the small PDD sample was associated with p.R47H.

Bibliografische Daten

Originalsprache	Englisch
ISSN	1353-8020
DOIs	https://doi.org/10.1016/j.parkreldis.2015.11.026
Status	Veröffentlicht - 01.02.2016

PubMed	26651418